Cognitive Impairment in Patients With Heart Failure

NCT00837889 | Completed

• 1 other identifier: 164/08
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 2

Brief Summary

The aim of the present study is threefold: investigating 1) specific cognitive impairments in patients with congestive heart failure, 2) whether cognitive impairments in patients with decompensated heart failure improve after medical recompensation and 3) whether cognitive functioning is related to the long-term prognosis (mortality, rehospitalisation) of those patients.

Conditions

Heart Failure; Cognitive Impairment

Keywords

cognition; decompensation; heart failure; recompensation

Outcome Measures

Primary Outcomes (3)

• cognitive function in decompensated heart failure patients measured by a cognitive test battery

  within 48h of hospitalisation

• cognitive function before and after medical recompensation measured by a cognitive test battery

  individual time to recompensate

• differences in cognitive performance between decompensated heart failure patients, patients with chronic heart failure and healthy controls

  14 months (+/-2 month)

Secondary Outcomes (2)

• all cause mortality

  12 month

• long-term development of cognitive functioning in patients with heart failure after acute decompensation

  3, 6, 12 and 18 months after acute decompensation

Study Arms (3)

decompensated heart failure patients

Drug: diuretics, inotropica

chronic heart failure patients

healthy controls

Interventions

diuretics, inotropica DRUG

decompensated heart failure patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

university hospital, saarland

You may qualify if:

• decompensated heart failure patients
• NYHA III-IV
• ejection fraction \< 35%

You may not qualify if:

• psychosis
• dementia
• major depression
• reanimation (\<3month)
• patients with assist device system

Sponsors & Collaborators

• Universität des Saarlandes: lead

Study Sites (2)

Department of Cardiology, University of the Saarland

Homburg, Saarland, 66421, Germany

Location

Developmental Psychology Unit, Saarland University

Saarbrücken, Saarland, 66111, Germany

Location

Related Publications (1)

• Kindermann I, Fischer D, Karbach J, Link A, Walenta K, Barth C, Ukena C, Mahfoud F, Kollner V, Kindermann M, Bohm M. Cognitive function in patients with decompensated heart failure: the Cognitive Impairment in Heart Failure (CogImpair-HF) study. Eur J Heart Fail. 2012 Apr;14(4):404-13. doi: 10.1093/eurjhf/hfs015.

  PMID: 22431406 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

Plasma

MeSH Terms

Conditions

Heart Failure; Cognitive Dysfunction

Interventions

Diuretics

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Natriuretic Agents; Physiological Effects of Drugs; Pharmacologic Actions; Chemical Actions and Uses

Study Officials

• Michael Böhm, MD

  University Hospital, Saarland

  PRINCIPAL INVESTIGATOR

• Ingrid Kindermann, MD

  University Hospital, Saarland

  PRINCIPAL INVESTIGATOR

• Denise Fischer, Psychologist

  University Hospital, Saarland

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 3, 2009
• First Posted: February 6, 2009
• Study Start: January 1, 2009
• Primary Completion: November 1, 2010
• Study Completion: May 1, 2011
• Last Updated: August 11, 2025

Record last verified: 2010-11

Locations

DE (2)