Correlation Between Skin Carotenoid Levels and Previous History of Skin Cancer
Comparison of Skin Carotenoid Levels Between Subjects With History of Cutaneous Squamous Cell Carcinoma and Subjects With History of Basal Cell Carcinoma Versus a Control Group
1 other identifier
observational
81
1 country
1
Brief Summary
The purpose of this study is to determine the difference of skin carotenoid levels between subjects with previous squamous cell carcinomas (SCC), subjects with previous basal cell carcinomas (BCC) and a control group.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Feb 2009
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2009
CompletedFirst Submitted
Initial submission to the registry
February 2, 2009
CompletedFirst Posted
Study publicly available on registry
February 4, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2012
CompletedResults Posted
Study results publicly available
July 25, 2012
CompletedJuly 25, 2012
June 1, 2012
2.9 years
February 2, 2009
May 14, 2012
June 24, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Skin Carotenoid Levels in Subjects With History of Squamous Cell Carcinoma Versus Control Subjects
Mean carotenoid levels in subjects with a history of squamous cell carcinoma were compared to mean carotenoid levels in control subjects without a history of nonmelanoma skin cancer.
baseline
Secondary Outcomes (2)
Skin Carotenoid Levels in Subjects With History of Squamous Cell Carcinoma Versus Subjects With History of Basal Cell Carcinoma
baseline
Skin Carotenoid Levels in Subjects With History of Basal Cell Carcinoma Versus Control Group
baseline
Study Arms (3)
Previous history of SCC
Participants had previous history of SCC
Previous history of BCC
Participants had previous history of BCC
Control
Participants had no previous history of squamous cell carcinoma or basal cell carcinoma
Eligibility Criteria
The research population were recruited from Massachusetts General Hospital dermatology clinics.
You may qualify if:
- Subjects between 50 and 75 years old without history of previous SCC or BCC.
- Fitzpatrick skin types I-IV.
- Willing and able to understand and sign informed consent.
- Able to complete study and comply with study procedures
You may not qualify if:
- Regular ingestion of supplements containing carotenoids or vitamin A in the past 4 weeks.
- Use of topical retinoids in the past 4 weeks.
- Treatment with systemic retinoids in the past 6 months.
- Dermatologic conditions that require the use of interfering topical or systemic therapy or that might interfere with study assessments such as, but not limited to, palmar psoriasis, hand dermatitis or palmo-plantar keratoderma.
- Previous history of psoriasis.
- Clinically significant abnormal findings or conditions, which might, in the opinion of the Principal Investigator, interfere with study evaluations or pose a risk to subject safety during the study.
- Subjects who are known to be pregnant or planning a pregnancy.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Massachusetts General Hospitallead
- Nu Skin Enterprisescollaborator
Study Sites (1)
Clinical Unit for Research Trials in Skin - MGH
Boston, Massachusetts, 02114, United States
Related Publications (5)
Bath-Hextall F, Leonardi-Bee J, Somchand N, Webster A, Delitt J, Perkins W. Interventions for preventing non-melanoma skin cancers in high-risk groups. Cochrane Database Syst Rev. 2007 Oct 17;2007(4):CD005414. doi: 10.1002/14651858.CD005414.pub2.
PMID: 17943854BACKGROUNDSantamaria L, Bianchi A. Cancer chemoprevention by supplemental carotenoids in animals and humans. Prev Med. 1989 Sep;18(5):603-23. doi: 10.1016/0091-7435(89)90033-9.
PMID: 2694158BACKGROUNDHeinen MM, Hughes MC, Ibiebele TI, Marks GC, Green AC, van der Pols JC. Intake of antioxidant nutrients and the risk of skin cancer. Eur J Cancer. 2007 Dec;43(18):2707-16. doi: 10.1016/j.ejca.2007.09.005. Epub 2007 Nov 7.
PMID: 17988857BACKGROUNDFrieling UM, Schaumberg DA, Kupper TS, Muntwyler J, Hennekens CH. A randomized, 12-year primary-prevention trial of beta carotene supplementation for nonmelanoma skin cancer in the physician's health study. Arch Dermatol. 2000 Feb;136(2):179-84. doi: 10.1001/archderm.136.2.179.
PMID: 10677093BACKGROUNDErmakov IV, Ermakova MR, McClane RW, Gellermann W. Resonance Raman detection of carotenoid antioxidants in living human tissues. Opt Lett. 2001 Aug 1;26(15):1179-81. doi: 10.1364/ol.26.001179.
PMID: 18049555BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Limitations and Caveats
Limitations include a small sample size
Results Point of Contact
- Title
- Kristen Corey
- Organization
- Clinical Unit for Research Trials in Skin, Massachusetts General Hospital
Study Officials
- PRINCIPAL INVESTIGATOR
Alexandra B Kimball, MD, MPH
Massachusetts General Hospital
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Director, Clinical Unit for Research Trials in Skin
Study Record Dates
First Submitted
February 2, 2009
First Posted
February 4, 2009
Study Start
February 1, 2009
Primary Completion
January 1, 2012
Study Completion
January 1, 2012
Last Updated
July 25, 2012
Results First Posted
July 25, 2012
Record last verified: 2012-06