Power Spectral Analysis of Breath Sound in Pulmonary Edema

NCT00767195 | Unknown DMC

• 2 other identifiers: VGHIRB97-01-02A200808065R
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Pulmonary edema can be classified into "cardiogenic pulmonary edema" and "non-cardiogenic pulmonary edema" according to the underlying etiology. Cardiogenic pulmonary edema is caused by the dysfunction in the cardiac pumping capability, leading to the transudation accumulation in the pulmonary peri-capillary space. The predisposing factors of non-cardiogenic pulmonary edema are numerous, including severe infection, renal failure, auto-immun reaction, etc. The mortality rate of pulmonary edema is relatively high, especially the non-cardiogenic one. To distinguish the type of pulmonary edema at the early stage is important for its treatment. Lung sound analysis via stethoscope is a simple diagnostic method to lung diseases clinically. Among many kinds of lung sounds, the "crackle" and "rale" are frequently found in pulmonary edema. "Rale" is also called "moist rale". It is considered as low-frequency wheezes and is often seen in cardiogenic pulmonary edema. On the other hand, "crackle" is also called "dry rale", which is a kind of high-frequency wheezes and usually seen in Acute Respiratory Distress Syndrome (ARDS) that is classified into non-cardiogenic pulmonary edema. This proposed project intends to establish a digital diagnostic method for pulmonary edema. The lung sound of patient with pulmonary edema will be collected by the lung sound acquisition system. By identifying the significant spectrum characteristics of cardiogenic pulmonary edema and non-cardiogenic pulmonary edema, the diagnostic system might be established.

Conditions

Pulmonary Edema

Keywords

pulmonary edema; cardiogenic; non-cardiogenic; mortality; length of stay

Study Arms (3)

1. Control group

Patients in the intensive care unit who have no pulmonary edema

2. Study group 1

Patients with cardiogenic pulmonary edema in the intensive care unit

3. Study group 2

Patients with non-cardiogenic pulmonary edema in the intensive care unit

Eligibility Criteria

• Age: 20 Years - 95 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients without pulmonary edema (control group), with cardiogrnic edema (study group 1) and non-cardiogrnic edema (study group 2)

You may qualify if:

• Patients in the intensive care unit using ventilator

You may not qualify if:

• Asthma, COPD, non-ventilated patients

Sponsors & Collaborators

• Taipei Veterans General Hospital, Taiwan: lead
• National Taiwan University Hospital: collaborator

Study Sites (1)

Intensive Care Unit

Taipei, 112, Taiwan

RECRUITING

MeSH Terms

Conditions

Pulmonary Edema

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases

Study Officials

• Low-Tone Ho, MD

  Taipei Veterans General Hospital, Taiwan

  STUDY CHAIR

Central Study Contacts

Cheng-Deng Kuo, MD,PhD

CONTACT

886-2-28757745; cdkuo@vghtpe.gov.tw

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV

Study Record Dates

• First Submitted: October 2, 2008
• First Posted: October 6, 2008
• Study Start: July 1, 2008
• Primary Completion: December 1, 2009
• Study Completion: December 1, 2009
• Last Updated: June 8, 2010

Record last verified: 2010-06

Locations

TW (1)