Strain-Encoded Cardiac Magnetic Resonance Imaging for Dobutamine Stress Testing

NCT00758654 | Completed

• 1 other identifier: MRI-021
• Study Type: observational
• Target: 320
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to compare the diagnostic value of SENC to that provided by conventional wall motion analysis for the detection of inducible ischemia during DS-MRI.High-dose dobutamine stress magnetic resonance imaging (DS-MRI) is safe and feasible for the diagnosis of coronary artery disease (CAD) in humans. However, the assessment of cine scans relies on the visual interpretation of regional wall motion, which is subjective. Recently, Strain-Encoded MRI (SENC) has been proposed for the direct color-coded visualization of myocardial strain.

Conditions

Coronary Artery Disease

Keywords

myocardial strain; Strain-Encoded MRI; dobutamine stress MRI; ischemia; strain rate reserve

Outcome Measures

Primary Outcomes (1)

• Detection of coronary artery disease (>50% diameter stenosis) by invasive angiography

  3 weeks

Secondary Outcomes (1)

• Long-term mortality and MACE

  2 years

Study Arms (2)

1

Patients with suspected or known stable coronary artery disease

2

Healthy subjects as a control group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Consecutive patients with suspected or known coronary artery disease and healthy volunteers serving as a contol group.

You may qualify if:

• Suspected or known coronary artery disease

You may not qualify if:

• General contraindication for a dobutamine stress or for an MRI examination
• Age \< 18 yrs

Sponsors & Collaborators

• Heidelberg University: lead

Study Sites (1)

University of Heidelberg, Department of Cardiology

Heidelberg, 69120, Germany

Location

Related Publications (2)

• Korosoglou G, Gitsioudis G, Voss A, Lehrke S, Riedle N, Buss SJ, Zugck C, Giannitsis E, Osman NF, Katus HA. Strain-encoded cardiac magnetic resonance during high-dose dobutamine stress testing for the estimation of cardiac outcomes: comparison to clinical parameters and conventional wall motion readings. J Am Coll Cardiol. 2011 Sep 6;58(11):1140-9. doi: 10.1016/j.jacc.2011.03.063.

  PMID: 21884952 DERIVED

• Korosoglou G, Lehrke S, Wochele A, Hoerig B, Lossnitzer D, Steen H, Giannitsis E, Osman NF, Katus HA. Strain-encoded CMR for the detection of inducible ischemia during intermediate stress. JACC Cardiovasc Imaging. 2010 Apr;3(4):361-71. doi: 10.1016/j.jcmg.2009.11.015.

  PMID: 20394897 DERIVED

MeSH Terms

Conditions

Coronary Artery Disease; Ischemia

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr.

Study Record Dates

• First Submitted: September 23, 2008
• First Posted: September 25, 2008
• Study Start: January 1, 2007
• Primary Completion: January 1, 2011
• Study Completion: January 1, 2011
• Last Updated: March 30, 2012

Record last verified: 2012-03

Locations

DE (1)