NCT00757211

Brief Summary

RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This study is looking at genetic susceptibility to cancer and interactions between genes and the environment in patients with breast cancer.

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
6,000

participants targeted

Target at P75+ for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2008

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

September 22, 2008

Completed
1 day until next milestone

First Posted

Study publicly available on registry

September 23, 2008

Completed
Last Updated

August 26, 2013

Status Verified

September 1, 2008

First QC Date

September 22, 2008

Last Update Submit

August 23, 2013

Conditions

Breast Cancer

Keywords

breast cancermale breast cancer

Outcome Measures

Primary Outcomes (5)

  • Acquisition of epidemiological information and biological material

  • Investigation of whether polymorphisms in putative cancer predisposition genes are associated with an increased risk of breast cancer

  • Proportion of breast cancer incidence attributable to mutations in such genes

  • Examination of the interactions between genetic and nongenetic risk factors

  • Evaluation of the relationship between pathological and clinical characteristics of breast cancers and germline genotype

Interventions

polymorphism analysisGENETIC
laboratory biomarker analysisOTHER
questionnaire administrationOTHER

Eligibility Criteria

Age18 Years - 70 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
DISEASE CHARACTERISTICS: * Diagnosis of breast cancer within the past 5 years * Identified through the East Anglian Cancer Registry in the East Anglia region of the United Kingdom * Hormone receptor status not specified PATIENT CHARACTERISTICS: * Menopausal status not specified * Identified by the patient's general practitioner as fit to contact for this study * No serious mental illness or retardation PRIOR CONCURRENT THERAPY: * Not specified

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (1)

University of Cambridge Cancer Research UK

Cambridge, England, CB1 8RN, United Kingdom

RECRUITING

MeSH Terms

Conditions

Breast NeoplasmsBreast Neoplasms, Male

Interventions

Amplified Fragment Length Polymorphism Analysis

Condition Hierarchy (Ancestors)

Neoplasms by SiteNeoplasmsBreast DiseasesSkin DiseasesSkin and Connective Tissue Diseases

Intervention Hierarchy (Ancestors)

DNA FingerprintingGenetic TechniquesInvestigative TechniquesPolymerase Chain ReactionNucleic Acid Amplification Techniques

Study Officials

  • Paul Pharoah, MD

    Cancer Research UK

    STUDY CHAIR

Study Design

Study Type
observational
Sponsor Type
OTHER

Study Record Dates

First Submitted

September 22, 2008

First Posted

September 23, 2008

Study Start

February 1, 2008

Last Updated

August 26, 2013

Record last verified: 2008-09

Locations

GB(1)