Laser-based Photoacoustic Tomography of Human Inflammatory Arthritis

NCT00748254 | Recruiting

• 2 other identifiers: HUM00003693R01AR060350
• Study Type: observational
• Target: 113
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this feasibility study is to determine if a new emerging technology called photoacoustic tomography (PAT) can be adapted for use in humans for the detection of chronic rheumatoid arthritis.

Conditions

Arthritis, Rheumatoid

Keywords

Rheumatoid arthritis

Outcome Measures

Primary Outcomes (1)

• Photoacoustic Imaging

  To determine if photoacoustic imaging (PAT) can accurately assist in the diagnosis of chronic rheumatoid arthritis, with data collected every 2 weeks for a maximum of 10 weeks.

  10 weeks

Study Arms (2)

Rheumatoid Arthritis

Patients who have active disease affecting the joints in the hand will have Laser Based Photoacoustic Tomography (PAT), MRI, Ultrasound

Procedure: Laser Based Photoacoustic Tomography, MRI, Ultrasound

Normal controls

Healthy volunteers who do not have arthritis will also have Laser Based Photoacoustic Tomography (PAT), MRI, Ultrasound on the joints of their hand

Procedure: laser based photoacoustic tomography, MRI, ultrasound

Interventions

laser based photoacoustic tomography, MRI, ultrasound PROCEDURE

Healthy subjects will have scans on finger joints with any of the scanning methods described above.

Also known as: MRI,magnetic resonance imaging, US, ultrasound, PAT, laser based photoacoustic tomography

Rheumatoid Arthritis

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects are 1) people who are either healthy volunteers or have patients who have rheumatoid arthritis for more than 2 years and who have a rheumatologist who referred them to this study.

You may qualify if:

• Men and women 18 years of age or older can participate in this study.
• Patients can participate in this study if they have had rheumatoid arthritis for more than 2 years and their rheumatologist has referred them to this study.
• Patients can participate as a healthy volunteer with a known history of rheumatoid arthritis.

You may not qualify if:

• Patients, who have electrically, magnetically or mechanically activated implants such as heart pacemaker, magnetic surgical clips, prostheses or implanted neurological stimulator.
• Pregnant patients.
• Patients who is claustrophobic.
• Patients with impaired renal function cannot participate in this study such as elevate creatinine clearance, patients on kidney dialysis etc.
• Patients with shock hypotension or unstable low blood pressure.
• Patients with Rhabdomyolysis.
• Patients who have had a contrast enhanced (with gadolinium) MRA (magnetic resonance angiography)/ or MRI within the last 3 months. (Contrast is a medication injected into a vein during a imaging examination that helps produce clearer images/pictures).

Sponsors & Collaborators

• University of Michigan: lead
• National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS): collaborator

Study Sites (1)

Universtity of Michigan Health System

Ann Arbor, Michigan, 48109, United States

RECRUITING

MeSH Terms

Conditions

Arthritis, Rheumatoid

Interventions

Magnetic Resonance Spectroscopy; High-Energy Shock Waves

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases

Intervention Hierarchy (Ancestors)

Spectrum Analysis; Chemistry Techniques, Analytical; Investigative Techniques; Ultrasonic Waves; Sound; Radiation, Nonionizing; Radiation; Physical Phenomena

Study Officials

• Xueding Wang, Ph.D

  University of Michigan

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Safa Mohamed

CONTACT

734 615-1646; safam@med.umich.edu

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 4, 2008
• First Posted: September 8, 2008
• Study Start: December 1, 2011
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): January 1, 2027
• Last Updated: January 23, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)