Microcirculation and Oxidative Stress in Critical Ill Patients in Surgical Intensive Care Unit

NCT00808691 | Completed

• 1 other identifier: 200707012
• Study Type: observational
• Target: 124
• Locations: 1 country
• Sites: 1

Brief Summary

As medicine advances, many lives can be saved in the intensive care unit. However, when multiple organ failure occurs, the mortality rate of patients increases dramatically. Therefore, the major goal in the intensive care unit is to prevent the occurrence of multiple organ failure. The sepsis protocol and early goal directed treatment have great effects to reduce development of multiple organ failure and to decrease the mortality rate. However, sometime the condition of patient deteriorated in spite of both the mean blood pressure and mixed venous oxygen saturation are normal. Some experts recognize that there might be microcirculatory dysfunction of tissue or organ. The dysfunction of microcirculation might due to vasoconstriction or microthrombosis. Vasoconstriction might result from systemic inflammation, reactive oxygen species, or dysfunction of synthesis of NO (nitric oxide). Microthrombosis might result from systemic inflammation, reactive oxygen species, imbalance of coagulatory system, or damage of endothelial cell. In clinical practice, the oxidative stress is related to circulatory shock, sepsis, acute lung injury, and acute respiratory distress syndrome. This study tries to investigate the relation between oxidative stress and microcirculation. Furthermore, the investigators will try to investigate the correlation between the severity of oxidative stress and microcirculatory dysfunction and the severity of disease and prognosis. The investigators hope this study will help them to figure out the picture of disease progression of patients. It may conduct further study to modulate the oxidative stress, to improve the microcirculatory function, and finally to improve the outcome of patients.

Conditions

Sepsis; ARDS; Liver Failure; Renal Failure; Brain Death

Outcome Measures

Primary Outcomes (1)

• Mortality Severity of Organ Failure

  28 days

Study Arms (6)

1

Patients with sepsis

Other: Critical care

2

Patient admitted for postoperative care

Other: Critical care

3

Patients with ARDS

Other: Critical care

4

Patients with ARF

Other: Critical care

5

Patients who receive liver support treatment

Other: Critical care

6

Patients wiht brain death

Other: Critical care

Interventions

Critical care OTHER

Standard care for each group of patients

1; 2; 3; 4; 5; 6

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Paitents admitted to intensive care unit with the following conditions Sepsis Postoperative care ARDS Renal Failure Liver failure Brain death

You may qualify if:

• \> 18 y/o
• Related diagnosis made within 24h
• Group 1 - Sepsis
• Group 2 - Postoperative care
• Group 3 - ARDS
• Group 4 - Renal failure
• Group 5 - Liver failure
• Group 6 - Brain death

You may not qualify if:

• Pregnant patients
• Related diagnosis made longer than 24h
• Patients who have received antioxidants within 24h
• Patients who have received hyperbaric oxygen therapy
• Patients who have a hemoglobin value less than 9 g/dl
• Patients who have received NO

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, Taiwan

Location

MeSH Terms

Conditions

Sepsis; Liver Failure; Renal Insufficiency; Brain Death

Interventions

Critical Care

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Hepatic Insufficiency; Liver Diseases; Digestive System Diseases; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Coma; Unconsciousness; Consciousness Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Death

Intervention Hierarchy (Ancestors)

Patient Care; Therapeutics; Health Services; Health Care Facilities Workforce and Services

Study Officials

• Yu-Chang Yeh, M.D

  National Taiwan University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 15, 2008
• First Posted: December 16, 2008
• Study Start: September 1, 2007
• Primary Completion: July 1, 2010
• Study Completion: July 1, 2011
• Last Updated: January 6, 2015

Record last verified: 2015-01

Locations

TW (1)