Effects of Transcranial Magnetic Stimulation to the Cerebellum on Cognition
fMRI and TMS Analysis of Cerebellar Cognitive Function
2 other identifiers
interventional
17
1 country
1
Brief Summary
Functional neuroimaging studies have shown that the cerebellum is active during cognitive performance. The investigators hypothesize that stimulation of the cerebellum with transcranial magnetic stimulation will produce brief changes in performance of the task, suggesting that cerebellar activation is necessary for normal cognitive function.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Apr 2000
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2000
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2005
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2005
CompletedFirst Submitted
Initial submission to the registry
August 22, 2008
CompletedFirst Posted
Study publicly available on registry
August 25, 2008
CompletedAugust 24, 2018
August 1, 2018
4.8 years
August 22, 2008
August 23, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Behavioral performance (accuracy, or rate of conditioned responses)
during computerized task performance (2 hours)
Secondary Outcomes (1)
Reaction time
during performance of computerized task (2 hours)
Study Arms (2)
Sham TMS
SHAM COMPARATORA Sham TMS coil, designed to elicit sham cerebellar transcranial magnetic stimulation, is used to administer sham TMS pulses after letters are presented.
TMS
EXPERIMENTALA genuine TMS coil is used to administer cerebellar transcranial magnetic stimulation pulses after letter presentation.
Interventions
single pulse TMS or repetitive TMS at 1 Hz frequency
Eligibility Criteria
You may qualify if:
- years of age
- Informed consent
You may not qualify if:
- History of seizure or a family history of epilepsy
- History of stroke
- Presence of metal anywhere in the head except the mouth
- Presence of cardiac pacemakers
- Presence of cochlear implants
- Presence of implanted medication pump
- History of heart disease
- Presence of intracardiac lines
- Increased intracranial pressure, such as after infarctions or trauma
- Children, or outside of age range
- Pregnancy
- Currently taking tricyclic anti-depressants or neuroleptic medication
- History of head trauma
- History of respiratory disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Johns Hopkins Universitylead
- National Institute of Mental Health (NIMH)collaborator
- National Institute on Aging (NIA)collaborator
Study Sites (1)
Kennedy Krieger Institute
Baltimore, Maryland, 21205, United States
Study Officials
- PRINCIPAL INVESTIGATOR
John E Desmond, Ph.D.
Johns Hopkins University
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 22, 2008
First Posted
August 25, 2008
Study Start
April 1, 2000
Primary Completion
January 1, 2005
Study Completion
January 1, 2005
Last Updated
August 24, 2018
Record last verified: 2018-08