Executive, Activities of Daily Living, and Cholinergic Functions in Parkinson's Disease

NCT00737217 | Completed

• 1 other identifier: 2005-0464
• Study Type: observational
• Target: 74
• Locations: 1 country
• Sites: 1

Brief Summary

This research study will evaluate functions of memory, thinking, behavior, and daily life activities and how these relate to the measurement of certain chemicals (acetylcholine and dopamine) in the brain using an imaging procedure called positron emission tomography (PET). You may know that in Alzheimer's dementia (dementia is a disease where persons become forgetful and confused), a reduction in the amount of acetylcholine, a "neurotransmitter" substance (a chemical messenger that nerve cells need to communicate with each other), may be responsible for some of the memory and behavioral changes. At the present time, the investigators have no clear information on the levels of acetylcholine in the brain of patients with Parkinson's disease who also have memory or behavioral changes.

Conditions

Parkinson's Disease

Study Arms (2)

Parkinson's disease

Behavioral: Behavioral assessment/questionnaire

Normal Controls

Behavioral: Behavioral assessment/questionnaire

Interventions

Behavioral assessment/questionnaire BEHAVIORAL

Complete behavioral assessment/questionnaire

Normal Controls; Parkinson's disease

Eligibility Criteria

• Age: 50 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with Parkinson's disease, either with or without memory or concentration difficulties, and normal control persons between the ages of 50-85 years are eligible to participate in this study. Participants should be willing and able to comply with study requirements. Normal control persons should not have a history of brain or mental disorders. Both males and females are eligible.

You may qualify if:

• PDD: Patients who meet the UK Parkinson's Disease Society Brain Bank Research Center (UKPDSBRC) clinical diagnostic criteria for PD with dementia (MMSE 18-25; n=28; age 50-85 years; M/F) are eligible for the study. Hoehn and Yahr stages I-III.
• PD. Patients with who meet the UKPDSBRC criteria for PD with a MMSE of \>25 (n=28; age 50-85 years; M/F). Hoehn and Yahr stages I-III.
• Normal control subjects (n=16) (age 50-85 years; M/F).
• No current or past history of neurologic or psychiatric illness.

You may not qualify if:

• Any subjects on cholinergic, anti-cholinergic drugs will be excluded from the study.
• Current or past history of neurologic or psychiatric illness.

Sponsors & Collaborators

• University of Michigan: lead
• Michael J. Fox Foundation for Parkinson's Research: collaborator

Study Sites (1)

University of Michigan Functional, Cognitive and Mobility Laboratory

Ann Arbor, Michigan, 48106, United States

Location

MeSH Terms

Conditions

Parkinson Disease

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: August 15, 2008
• First Posted: August 18, 2008
• Study Start: March 1, 2006
• Primary Completion: April 1, 2009
• Study Completion: April 1, 2009
• Last Updated: June 26, 2013

Record last verified: 2013-06

Locations

US (1)