NCT01052350

Brief Summary

The purpose of this study is to use a brain imaging method called PIB PET to determine dementia subtypes in patients with Parkinson's disease. The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
320

participants targeted

Target at P75+ for all trials

Timeline
49mo left

Started Aug 2006

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress83%
Aug 2006Jul 2030

Study Start

First participant enrolled

August 1, 2006

Completed
3.5 years until next milestone

First Submitted

Initial submission to the registry

January 15, 2010

Completed
5 days until next milestone

First Posted

Study publicly available on registry

January 20, 2010

Completed
20.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2030

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2030

Last Updated

May 12, 2026

Status Verified

May 1, 2026

Enrollment Period

23.9 years

First QC Date

January 15, 2010

Last Update Submit

May 6, 2026

Conditions

Parkinson's Disease

Keywords

Parkinson diseasePET imagingPIBdementia

Study Arms (2)

Parkinson disease

individuals with Parkinson disease

healthy control

individuals without Parkinson disease

Eligibility Criteria

Age50 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Participants with and without Parkinson disease will be recruited from the Movement Disorders Center at Washington University, the St. Louis metro area, and throughout the midwest region.

You may qualify if:

  • PD patients must exhibit three of the following cardinal signs: rest tremor, rigidity, bradykinesia, or postural instability; or two of these features with one of the first three displaying asymmetry.

You may not qualify if:

  • history of head trauma, major neurological or psychiatric diseases other than Parkinson disease and dementia, e.g. stroke, multiple sclerosis, depression or schizophrenia
  • severe systemic diseases
  • inability to lie still for 90 minutes
  • metallic implants, pacemakers, or any other contraindication to MRI
  • refusal to consent to brain donation

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

NeuroClinical Research Unit (NCRU), Washington University School of Medicine

St Louis, Missouri, 63110, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

whole blood

MeSH Terms

Conditions

Parkinson DiseaseDementia

Condition Hierarchy (Ancestors)

Parkinsonian DisordersBasal Ganglia DiseasesBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesMovement DisordersSynucleinopathiesNeurodegenerative DiseasesNeurocognitive DisordersMental Disorders

Study Officials

  • Joel S. Perlmutter, MD

    Washington University School of Medicine

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 15, 2010

First Posted

January 20, 2010

Study Start

August 1, 2006

Primary Completion (Estimated)

July 1, 2030

Study Completion (Estimated)

July 1, 2030

Last Updated

May 12, 2026

Record last verified: 2026-05

Locations

US(1)