Magnetic Resonance Imaging (MRI) of Appendicitis in Children

NCT00723788 | Completed Results

• 1 other identifier: CNMC4024
• Study Type: interventional
• Target: 21
• Locations: 1 country
• Sites: 1

Brief Summary

Study to find out if MRI can diagnose appendicitis in children as well as or better than CT scan and/or ultrasound scan performed at the same time. No additional contrast material or sedation will be used to perform the MRI.

Conditions

Appendicitis

Keywords

Appendicitis; Children; Magnetic Resonance Imaging

Outcome Measures

Primary Outcomes (1)

• Diagnostic Sensitivity/Specificity and Accuracy of Appendiceal MRI Comparedsurgical Findings or Clinical Follow-up

  Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV)

  during diagnostic procedure

Study Arms (1)

Only one arm

EXPERIMENTAL

All patients enrolled will receive an MRI of the abdomen with detailed views of the appendix

Device: MRI of the abdomen

Interventions

MRI of the abdomen DEVICE

Multiple MRI pulse sequences of the abdomen

Only one arm

Eligibility Criteria

• Age: 8 Years - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Age 8-18 years, referred from emergency department for suspected appendicitis and receiving either CT scan or ultrasound of the abdomen for diagnosis

You may not qualify if:

• Failure to pass MRI metal screening. Claustrophobia or need for sedation due to inability to hold still.

Sponsors & Collaborators

• Children's National Research Institute: lead

Study Sites (1)

Children's National Medical Center

Washington D.C., District of Columbia, 20010, United States

Location

Related Publications (4)

• Hormann M, Paya K, Eibenberger K, Dorffner R, Lang S, Kreuzer S, Metz VM. MR imaging in children with nonperforated acute appendicitis: value of unenhanced MR imaging in sonographically selected cases. AJR Am J Roentgenol. 1998 Aug;171(2):467-70. doi: 10.2214/ajr.171.2.9694477.

  PMID: 9694477 BACKGROUND

• Hormann M, Puig S, Prokesch SR, Partik B, Helbich TH. MR imaging of the normal appendix in children. Eur Radiol. 2002 Sep;12(9):2313-6. doi: 10.1007/s00330-002-1351-0. Epub 2002 May 9.

  PMID: 12195487 BACKGROUND

• Pedrosa I, Levine D, Eyvazzadeh AD, Siewert B, Ngo L, Rofsky NM. MR imaging evaluation of acute appendicitis in pregnancy. Radiology. 2006 Mar;238(3):891-9. doi: 10.1148/radiol.2383050146.

  PMID: 16505393 BACKGROUND

• Incesu L, Coskun A, Selcuk MB, Akan H, Sozubir S, Bernay F. Acute appendicitis: MR imaging and sonographic correlation. AJR Am J Roentgenol. 1997 Mar;168(3):669-74. doi: 10.2214/ajr.168.3.9057512.

  PMID: 9057512 BACKGROUND

MeSH Terms

Conditions

Appendicitis

Condition Hierarchy (Ancestors)

Intraabdominal Infections; Infections; Gastroenteritis; Gastrointestinal Diseases; Digestive System Diseases; Cecal Diseases; Intestinal Diseases

Results Point of Contact

• Title: Pranav Vyas, MD
• Organization: Children's National Health System

PVyas@childrensnational.org

2024760186

Study Officials

• Pranav K Vyas, MD

  Children's National Research Institute

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor of Radiology and Pediatrics

Study Record Dates

• First Submitted: July 25, 2008
• First Posted: July 29, 2008
• Study Start: August 1, 2008
• Primary Completion: April 1, 2010
• Study Completion: April 1, 2010
• Last Updated: November 21, 2014
• Results First Posted: November 21, 2014

Record last verified: 2014-11

Locations

US (1)