NCT00707694|RecruitingDMC
The Longevity Genes in Founder Populations Project
Searching for Longevity Genes in the Historically Unique Ashkenazi Jewish Population
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Searching for Longevity Genes in the Historically Unique Ashkenazi Jewish Population
Sponsor study identifier
Secondary identifiers
observational
2,000
1 country
2
Study Start
July 1998
Actual (reported)Primary Completion
December 2032
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 2032
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
We believe extreme longevity is due to specific genes which function to delay aging and prevent disease. The purpose of the research is to identify the genes/mutations associated with healthier aging; to understand the biological functions of these genes/mutations; and to develop therapies to replicate these preservative genetic activities in individuals who do not have the genetic profile for longevity.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2032
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
July 1998
Actual (reported)June 27, 2008
Actual (reported)July 1, 2008
Actual (reported)December 2032
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
December 2032
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Ashkenazi Jews ages 95 and older
Ashkenazi Jewish offspring of Ashkenazi Jewish parent(s) who lived to at least the age of 95
Ashkenazi Jewish people with no family history of longevity
Ashkenazi Jews: Ages 95 and older, their offspring and control group with no family history of longevity.
Private Homes
New York, New York, United States
Hebrew Home Riverdale
Riverdale, New York, 10471, United States
DeVito LM, Barzilai N, Cuervo AM, Niedernhofer LJ, Milman S, Levine M, Promislow D, Ferrucci L, Kuchel GA, Mannick J, Justice J, Gonzales MM, Kirkland JL, Cohen P, Campisi J. Extending human healthspan and longevity: a symposium report. Ann N Y Acad Sci. 2022 Jan;1507(1):70-83. doi: 10.1111/nyas.14681. Epub 2021 Sep 8.
Moqri M, Herzog C, Poganik JR; Biomarkers of Aging Consortium; Justice J, Belsky DW, Higgins-Chen A, Moskalev A, Fuellen G, Cohen AA, Bautmans I, Widschwendter M, Ding J, Fleming A, Mannick J, Han JJ, Zhavoronkov A, Barzilai N, Kaeberlein M, Cummings S, Kennedy BK, Ferrucci L, Horvath S, Verdin E, Maier AB, Snyder MP, Sebastiano V, Gladyshev VN. Biomarkers of aging for the identification and evaluation of longevity interventions. Cell. 2023 Aug 31;186(18):3758-3775. doi: 10.1016/j.cell.2023.08.003.
Nir Barzilai, MD
Albert Einstein College of Medicine
First Submitted
June 27, 2008
First Posted
July 1, 2008
Study Start
July 1998
Actual (reported)Primary Completion
December 2032
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Contact the study team to confirm eligibility.
Moqri M, Herzog C, Poganik JR, Ying K, Justice JN, Belsky DW, Higgins-Chen AT, Chen BH, Cohen AA, Fuellen G, Hagg S, Marioni RE, Widschwendter M, Fortney K, Fedichev PO, Zhavoronkov A, Barzilai N, Lasky-Su J, Kiel DP, Kennedy BK, Cummings S, Slagboom PE, Verdin E, Maier AB, Sebastiano V, Snyder MP, Gladyshev VN, Horvath S, Ferrucci L. Validation of biomarkers of aging. Nat Med. 2024 Feb;30(2):360-372. doi: 10.1038/s41591-023-02784-9. Epub 2024 Feb 14.
Bae H, Song Z, Ali A, Sasaki T, Tesi N, Lords H, Leshchyk A, Abe Y, Hirose N, Arai Y, Barzilai N, Weiss EF, Hulsman M, van der Lee S, van Schoor NM, Huisman M, Pijnenburg Y, van der Flier W, Reinders M, Holstege H, Milman S, Perls TT, Andersen SL, Sebastiani P. Increased genetic protection against Alzheimer's disease in centenarians. Geroscience. 2026 Apr;48(2):1815-1827. doi: 10.1007/s11357-025-01774-8. Epub 2025 Jul 4.
Ali A, Zhang ZD, Gao T, Aleksic S, Gavathiotis E, Barzilai N, Milman S. Identification of functional rare coding variants in IGF-1 gene in humans with exceptional longevity. Sci Rep. 2025 Mar 25;15(1):10199. doi: 10.1038/s41598-025-94094-y.
Ying K, Castro JP, Shindyapina AV, Tyshkovskiy A, Moqri M, Goeminne LJE, Milman S, Zhang ZD, Barzilai N, Gladyshev VN. Depletion of loss-of-function germline mutations in centenarians reveals longevity genes. Nat Commun. 2024 Oct 19;15(1):9030. doi: 10.1038/s41467-024-52967-2.
Barzilai N, Gabriely I, Atzmon G, Suh Y, Rothenberg D, Bergman A. Genetic studies reveal the role of the endocrine and metabolic systems in aging. J Clin Endocrinol Metab. 2010 Oct;95(10):4493-500. doi: 10.1210/jc.2010-0859.
Study Completion
December 2032
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
January 2, 2026
Record last verified: 2025-12
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