Longevity Families of the Netherlands

NCT06374069 | Recruiting

• 1 other identifier: NL81887.058.23
• Study Type: observational
• Target: 600
• Locations: 1 country
• Sites: 1

Brief Summary

The demographic life expectancy enhancement of the past 150 years imposes an urgent challenge in Western and economically growing societies to stimulate the healthy lifespan that is lagging behind. Families surviving into exceptionally high ages (longevity) in good physical and mental health illustrate that this is physiologically possible. Such families harbor cross generational socio-genetic mechanisms that mediate healthy aging and protection from (multi)morbidity. The purpose of our research is: to identify gene variants associated with healthy aging and protection from (multi)morbidity; to study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component.

Conditions

Longevity; Familial Longevity; Extreme Longevity; Aging

Outcome Measures

Primary Outcomes (1)

• Identifying the genetic variants of Familial Longevity

  To identify gene variants associated with healthy aging and protection from (multi)morbidity

  through study completion, an average of 2 years

Secondary Outcomes (1)

• Studying the environmental factor of Familial Longevity through questionnaires and its interaction with the genetic component

  through study completion, an average of 2 years

Study Arms (2)

Cases - Enriched for familial longevity

Siblings of dutch Caucasian descent ages 75 and older

Controls - Non-enriched for familial longevity

Individuals of dutch Caucasian descent ages 75 and older solely in their family.

Eligibility Criteria

• Age: 75 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Dutch Caucasian descent: Ages 75 and older, with siblings enriched for familial longevity, and individuals without a history of familial longevity

You may qualify if:

• Siblings of Dutch Caucasian descent age 75+ enriched for familial longevity
• Individuals of Dutch Caucasian descent age 75+ who are not enriched for familial longevity

Sponsors & Collaborators

• Leiden University Medical Center: lead
• Jacobijn Gussekloo, Prof. dr.: collaborator
• Simon P. Mooijaart, Prof. dr.: collaborator

Study Sites (1)

Leiden University Medical Center

Leiden, South Holland, 2333ZA, Netherlands

RECRUITING

Central Study Contacts

(Eline) P. Slagboom, Prof. dr.

CONTACT

+31(0)71 5269 730; p.slagboom@lumc.nl

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Eline Slagboom, Prof. dr.

Study Record Dates

• First Submitted: March 20, 2024
• First Posted: April 18, 2024
• Study Start: September 11, 2023
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: April 18, 2024

Record last verified: 2024-04

Locations

NL (1)