Manipulating Cognitive Intensity During Aerobic Exercise

NCT06479265 | Completed

• 1 other identifier: HS-21-00356
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate the performance effects of manipulating the properties of a cognitively engaging aerobic task. The overall goal of this proposal is to determine how changes in aspects of the task (selection time, number of sorting options) and inclusion of different dual task walking interferences can be used to challenge the cognitive domain of executive function in a range of healthy adults. The investigators hope to learn how to challenge people cognitively during exercise to promote mental benefits. Participants are invited as a possible participant because are a healthy adult. 40 participants will take part in the study. This research is being funded by the Clinical Exercise Research Center (CERC) in the Division of Biokinesiology and Physical Therapy on the University of Southern California Health Sciences Campus.

Conditions

Cognitive Decline

Outcome Measures

Primary Outcomes (1)

• Cognitive Task Performance

  Score of the Wisconsin Card Sorting Task 64 for each Trial

  90 minutes - 120 minutes

Study Arms (2)

Older Adults

Healthy, adult age 65-75.

Other: Phyical/Cognitve Exercise

Younger Adults

Healthy, young adult age 18-29.

Other: Phyical/Cognitve Exercise

Interventions

Phyical/Cognitve Exercise OTHER

Participants will report to the CERC and review informed consent with a study investigator. Eligibility assessments (PAR-Q, WCST64, Medical History) will be done post-consent. Data collected will include age, body composition, gender, aerobic capacity, chronic medication use, and treated pathologies. All measurements will occur during one visit. Participants will lay supine for 5 minutes to measure resting heart rate (HR) using an HR monitor. This resting HR, with age-predicted HR max, will determine HR reserve (HRR). Participants will master the WCST64 and identify walking pace on the Blue Goji treadmill. They will complete a baseline 10 Meter Walk Test, followed by the digital WCST64 under 7 conditions, ending with a post-intervention 10 Meter Walk Test.

Older Adults; Younger Adults

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy 18-29 year old men and women and health 65-75 year old men and women.

You may qualify if:

• year old men and women; 65-75 year old men and women
• Competency in English sufficient for assessment and training
• Able to see and hear sufficiently to participate
• Answer YES to all questions on the Physical Activity Readiness Questionnaire (PAR-Q) or receive medical clearance from a physician

You may not qualify if:

• History of known neurological disease (e.g., Epilepsy, Multiple sclerosis, Parkinson disease, Alzheimer's disease), cerebral infarct (e.g., Stroke), or traumatic brain injury
• History of known cardiovascular or metabolic disease or chronic illness which may compromise the patient's ability to safely perform the aerobic exercise (e.g., coronary artery disease, arrhythmia, asthma requiring an inhaler during exercise), or presently uncontrolled hypertension (SBP \> 140 mmHg or DBP \> 90 mmHg).
• Musculoskeletal injuries interfering with the ability to perform aerobic exercise or medical conditions for which exercise in contraindicated
• Individuals with medical implant devices such as pacemakers, or essential support devices such as patient monitoring systems, must not use this equipment. Safe, low-level currents will flow through the body duringthe test, which may cause malfunctioning of the device or endanger lives.
• Bioelectrical Impedance Analysis (BIA) uses safe low level currents, which are not harmful to the body. However, we do not recommend pregnant women test.

Sponsors & Collaborators

• University of Southern California: lead

Study Sites (1)

Clinical Exercise Research Center

Los Angeles, California, 90033, United States

Location

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Malcolm Jones, PhD

  University of Southern California

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of Health Innovation

Study Record Dates

• First Submitted: June 13, 2024
• First Posted: June 28, 2024
• Study Start: January 15, 2021
• Primary Completion: May 15, 2022
• Study Completion: May 15, 2022
• Last Updated: June 28, 2024

Record last verified: 2024-06

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)