was replaced by another study. Problems with recruitment.
Systematic Characterization of the Cellular Proteome From Human Leukocytes of Glaucoma Patients in Comparison With Patients With Alzheimer's Disease
Sponsor study identifier
observational
0
0 countries
N/A
Study Start
June 2008
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
August 2011
Actual (reported)Study Completion
August 2011
Actual (reported)Glaucoma is a worldwide leading cause of blindness. The key feature of this ocular neuropathy is characterized by an excavating optic nerve head. Loss of retinal ganglion cells is the final end point in blinding diseases of the optic nerve such as glaucoma. It is known that neuronal cell death in glaucoma occurs by an apoptotic mechanism. In earlier studies the investigators could demonstrate that the process of apoptosis is reflected in circulating leukocytes by different parameters, like differential mRNA expression and an increased fragmentation of the DNA. Such alterations point out a relationship between cellular stress and apoptotic events. Based on the results of mRNA-expression the investigators also expect alterations on the protein level. This study is, therefore, designed to characterize the proteome related to the proteins involved in cell death related pathways. Thus, the expression pattern of several proteins in leukocytes from patients with primary open angle glaucoma will be analyzed by techniques like Western-blot and tandem mass spectrometry. These samples will be compared with samples from healthy controls. In addition, they will also be compared with samples from patients with Alzheimer's disease. Since glaucoma is a neurodegenerative disease, these patients will be included as positive controls in this study.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 2011
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 2008
Date type not reportedThis date has not been verified as actual or estimated.
June 3, 2008
Actual (reported)June 5, 2008
Actual (reported)August 2011
Actual (reported)August 2011
Actual (reported)Control 1 (young subjects)
Control 2 (old subjects)
Glaucoma patients
Alzheimer patients
Glaucoma patients Alzheimer's patients
plasma
Selim Orguel, MD
University Hospital, Basel, Switzerland
0 participants (actual enrollment reported by the registry).
First Submitted
June 3, 2008
First Posted
June 5, 2008
Study Start
June 2008
Date type not reportedThis date has not been verified as actual or estimated.
Effect of Glaucoma Educators on Adherence to Prescribed Therapeutic Regimens in Glaucoma Patients
Contact the study team to confirm eligibility.
Primary Completion
August 2011
Actual (reported)Study Completion
August 2011
Actual (reported)Last Updated
March 10, 2015
Record last verified: 2015-03
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Source: ClinicalTrials.gov.
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