was replaced by an other study
Systematic Characterization of the Cellular Proteome From Human Leukocytes of Glaucoma Patients in Comparison With Patients With Parkinson's Disease
Sponsor study identifier
observational
0
0 countries
N/A
Study Start
October 2006
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
May 2008
Actual (reported)Study Completion
Not reported
Date not reportedGlaucoma is a worldwide leading cause of blindness. The key feature of this ocular neuropathy is characterized by an excavating optic nerve head. Loss of retinal ganglion cells is the final end point in blinding diseases of the optic nerve such as glaucoma. It is known that neuronal cell death in glaucoma occurs by an apoptotic mechanism. In earlier studies the investigators could demonstrate that the process of apoptosis is reflected in circulating leukocytes by different parameters, like differential mRNA expression and an increased fragmentation of the DNA. Such alterations point out a relationship between cellular stress and apoptotic events. Based on the results of mRNA-expression the investigators also expect alterations on the protein level. This study is, therefore, designed to characterize the proteome related to the proteins involved in cell death related pathways. Thus, the expression pattern of several proteins in leukocytes from patients with primary open angle glaucoma will be analyzed by techniques like Western-blot and tandem mass spectrometry. These samples will be compared with samples from healthy controls. In addition, they will also be compared with samples from patients with Parkinson's disease. Since glaucoma is a neurodegenerative disease, these patients will be included as positive controls in this study.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
Not reported
Date not reportedClick on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 17, 2006
Actual (reported)May 18, 2006
Actual (reported)October 2006
Date type not reportedThis date has not been verified as actual or estimated.
May 2008
Actual (reported)glaucoma patients
plasma
Selim Orgül, MD
University Hospital, Basel, Switzerland
0 participants (actual enrollment reported by the registry).
First Submitted
May 17, 2006
First Posted
May 18, 2006
Study Start
October 2006
Date type not reportedThis date has not been verified as actual or estimated.
Effect of Glaucoma Educators on Adherence to Prescribed Therapeutic Regimens in Glaucoma Patients
Contact the study team to confirm eligibility.
Primary Completion
May 2008
Actual (reported)Last Updated
March 10, 2015
Record last verified: 2015-03
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Source: ClinicalTrials.gov.
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