Hemodynamic Measurements During Liver Transplantation
OLT
Comparing Different Methods For Measurement of Cardiac Output During Orthotopic Liver Transplantation
1 other identifier
observational
30
1 country
1
Brief Summary
The purpose of the study is to determine if the less invasive monitors are as reliable for measuring heart function in patients undergoing liver transplantation as the more invasive pulmonary artery.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Jul 2007
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2007
CompletedFirst Submitted
Initial submission to the registry
May 16, 2008
CompletedFirst Posted
Study publicly available on registry
May 22, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2010
CompletedApril 1, 2010
March 1, 2010
1.5 years
May 16, 2008
March 31, 2010
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Agreement between cardiac output measurements obtained with PAC, Vigileo and LiDCO
Specific phases of liver transplantation surgery
Eligibility Criteria
20 subjects will be enrolled in this observational study in the Liver Transplant Group; 10 patients in the Other Surgery Control Group for a total of 30 subjects. Patients will be recruited from the Operating Room schedule. Written, informed consent will be obtained from each subject prior to surgery. All participants will be informed that they may decline to participate in, or withdraw from, the study at any time.
You may qualify if:
- Patients over 18 years of age
- Scheduled for liver transplantation
- Patient undergoing vascular surgery where invasive arterial pressure is indicated (control subjects)
You may not qualify if:
- We will exclude patients taking lithium based medication
- Patients who weigh less than 40 kg; AND
- Patients who are pregnant
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Washington University School of Medicine
St Louis, Missouri, 63110, United States
Related Publications (3)
Vannucci A, Burykin A, Krejci V, Peck T, Buchman TG, Kangrga IM. Postreperfusion cardiac arrest and resuscitation during orthotopic liver transplantation: dynamic visualization and analysis of physiologic recordings. Shock. 2012 Jan;37(1):34-8. doi: 10.1097/SHK.0b013e318239b128.
PMID: 22089184DERIVEDKrejci V, Vannucci A, Abbas A, Chapman W, Kangrga IM. Comparison of calibrated and uncalibrated arterial pressure-based cardiac output monitors during orthotopic liver transplantation. Liver Transpl. 2010 Jun;16(6):773-82. doi: 10.1002/lt.22056.
PMID: 20517912DERIVEDVannucci A, Krejci V, Kangrga I. Performance of Vigileo and LiDCOplus cardiac output monitors during a prolonged cardiac arrest and resuscitation. Eur J Anaesthesiol. 2009 Oct;26(10):885-7. doi: 10.1097/EJA.0b013e32832fa5db. No abstract available.
PMID: 19606043DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Ivan Kangrga, MD, PhD
Washington University School of Medicine
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
May 16, 2008
First Posted
May 22, 2008
Study Start
July 1, 2007
Primary Completion
January 1, 2009
Study Completion
March 1, 2010
Last Updated
April 1, 2010
Record last verified: 2010-03