Coronary Artery Disease and Renal Failure Registry
CAD-REF
1 other identifier
observational
3,352
1 country
32
Brief Summary
It is the aim of the multi-centric and prospective registry to analyze in patients with CAD the impact of different grades of renal failure on the outcome and course of the patients and to correlate these with clinical variables. In particular, the registry has the following objectives:
- prospective consecutive assessment of all patients with coronary artery disease and renal failure in the participating hospitals of the registry
- evaluation of the outcome and course of patients with regard to their different stages of renal failure at baseline
- analysis of the impact of different therapeutic strategies on acute and long-term outcomes
- identification of clinical risk factors, novel biomarkers and genetic markers for an unfavorable long-term outcome
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Dec 2007
Longer than P75 for all trials
32 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2007
CompletedFirst Submitted
Initial submission to the registry
May 14, 2008
CompletedFirst Posted
Study publicly available on registry
May 16, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2013
CompletedNovember 2, 2012
October 1, 2012
3.4 years
May 14, 2008
November 1, 2012
Conditions
Outcome Measures
Primary Outcomes (1)
all cause mortality
two years
Secondary Outcomes (1)
manner of death
two years
Other Outcomes (1)
Interventions
two years
Study Arms (6)
Group 0 (Controllgroup)
eGFR \>= 90 ml/min/1.73m\^2 and no proteinuria
Group 1
eGFR \>= 90 ml/min/1.73m\^2 and proteinuria
Group 2
eGFR 60 - 89 ml/min/1.73m\^2
Group 3
eGFR 30 - 59 ml/min/1.73m\^2
Group 4
eGFR 15 - 29 ml/min/1.73m\^2
Group 5
eGFR \< 15 ml/min/1.73m\^2 or requiring dialysis
Eligibility Criteria
Patients with diagnosed coronary artery disease were consecutively enrolled and classified into six groups according to their kidney function
You may qualify if:
- Women and men \>= 18 years of age
- Patients with actually performed interventional coronary angiography and there a documented coronary heart disease, defined as at least one documented stenosis \>= 50 % in at least one main coronary vessel (Main steam; RCX; RIVA; RCA)
- European/Caucasian descent (European/Caucasian parents and grandparents)
- Availability of an urine, serum- and EDTA blood sample of the patient
- Documented consent of patients for handling of personal medical data, including a genetic analysis
You may not qualify if:
- Patients who have been already recruited into this registry
- Patients with organ transplantations, apart from kidney transplantations
- Immunosuppressive therapy, apart from immunosuppressive therapy after kidney transplantation
- Patients with polycystic renal disease
- Pregnant and breastfeeding patients
- Known malignant tumor
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Institut für Klinisch-Kardiovaskuläre Forschung GmbHlead
- BMBf (Federal Ministry of Education and Research)collaborator
- KfH Kuratorium für Dialyse und Nierentransplantation e.V.collaborator
- Amgencollaborator
- AstraZenecacollaborator
- Boehringer Ingelheimcollaborator
- Sanoficollaborator
Study Sites (32)
Universitätsklinikum Aachen
Aachen, Germany
Zentralklinik Bad Berka
Bad Berka, Germany
Herz- und Gefäßklinik Bad Neustadt
Bad Neustadt an der Saale, Germany
Schüchtermann-Klinik
Bad Rothenfelde, Germany
Herzzentrum Brandenburg
Brandenburg, Germany
St.-Vincenz-Hospital
Coesfeld, Germany
Klinikum Lippe-Detmold
Detmold, Germany
Herzzentrum Duisburg
Duisburg, Germany
Evangelisches Krankenhaus Düsseldorf
Düsseldorf, Germany
Alfried Krupp Krankenhaus Essen
Essen, Germany
Klinikum Garmisch-Partenkirchen
Garmisch-Partenkirchen, Germany
Universitätsklinikum Halle/Saale
Halle, Germany
Universitätsklinikum Hamburg-Eppendorf
Hamburg, Germany
Evangelisches Krankenhaus Hamm
Hamm, Germany
St. Marienhospital Hamm
Hamm, Germany
Medizinische Hochschule Hannover
Hanover, Germany
SLK-Kliniken Heilbronn GmbH
Heilbronn, Germany
Privatklinik Dr. Schindlbeck
Herrsching am Ammersee, Germany
Herzzentrum Lahr
Lahr, Germany
Kardiologische Praxis Dr. Schön
Mühldorf, Germany
Klinik Augustium München
München, Germany
Klinikum Neuperlach
München, Germany
Raphaelsklinik Münster
Münster, Germany
St. Franziskus-Hospital
Münster, Germany
Universitätsklinikum Münster
Münster, Germany
Lukaskrankenhaus Neuss
Neuss, Germany
Euregioclinic Nordhorn
Nordhorn, Germany
St. Vincenz-Krankenhaus
Paderborn, Germany
Klinikum Pirna
Pirna, Germany
Christliches Krankenhaus Quakenbrück e.V.
Quakenbrück, Germany
Zentralklinikum Suhl
Suhl, Germany
Josephs-Hospital Warendorf
Warendorf, Germany
Related Publications (3)
Engelbertz C, Pinnschmidt HO, Freisinger E, Reinecke H, Schmitz B, Fobker M, Schmieder RE, Wegscheider K, Breithardt G, Pavenstadt H, Brand E. Sex-specific differences and long-term outcome of patients with coronary artery disease and chronic kidney disease: the Coronary Artery Disease and Renal Failure (CAD-REF) Registry. Clin Res Cardiol. 2021 Oct;110(10):1625-1636. doi: 10.1007/s00392-021-01864-5. Epub 2021 May 26.
PMID: 34036426DERIVEDEngelbertz C, Reinecke H, Breithardt G, Schmieder RE, Fobker M, Fischer D, Schmitz B, Pinnschmidt HO, Wegscheider K, Pavenstadt H, Brand E. Two-year outcome and risk factors for mortality in patients with coronary artery disease and renal failure: The prospective, observational CAD-REF Registry. Int J Cardiol. 2017 Sep 15;243:65-72. doi: 10.1016/j.ijcard.2017.05.022. Epub 2017 May 7.
PMID: 28526542DERIVEDBrand E, Pavenstadt H, Schmieder RE, Engelbertz C, Fobker M, Pinnschmidt HO, Wegscheider K, Breithardt G, Reinecke H. The Coronary Artery Disease and Renal Failure (CAD-REF) registry: trial design, methods, and aims. Am Heart J. 2013 Sep;166(3):449-56. doi: 10.1016/j.ahj.2013.06.010. Epub 2013 Jul 23.
PMID: 24016493DERIVED
Related Links
Biospecimen
Urine, whole blood, serum
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Eva Brand, Prof. Dr.
University Hospital of Muenster
- PRINCIPAL INVESTIGATOR
Holger Reinecke, Prof. Dr.
University Hospital of Muenster
- PRINCIPAL INVESTIGATOR
Günter Breithardt, Prof. Dr.
University Hospital of Muenster
- PRINCIPAL INVESTIGATOR
Hermann Pavenstädt, Prof. Dr.
University Hospital of Muenster
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- NETWORK
Study Record Dates
First Submitted
May 14, 2008
First Posted
May 16, 2008
Study Start
December 1, 2007
Primary Completion
May 1, 2011
Study Completion
May 1, 2013
Last Updated
November 2, 2012
Record last verified: 2012-10