Follow up of Ventilatory Function in Infant After Bronchiolitis During the First Year of Life

NCT00676351 | Completed

• 1 other identifier: 02-PHRC-05
• Study Type: interventional
• Target: 29
• Locations: 1 country
• Sites: 1

Brief Summary

A significant proportion of asthma is diagnosed during childhood. Bronchiolitis is the most common lower respiratory tract illness (LRI) in early life and the present work is a prospective study undertaken to highlight the possible relationship between LRI in early life and trigger of atopy and asthma in 3 year-old childhood, using paediatric lung function testing. Twenty nine infants (8 females and 21 males) were included in our study. The beginning of the study started at least three weeks after the first bronchiolitis episode. Pulmonary function test was realized using an infant specific body plethysmography (Babybody, Erich Jaeger, Germany). Same tests were performed at 18 and 24 months. At 30 and 36 months, pulmonary function was evaluated by measuring respiratory resistances using oscillometry and occlusion systems (Masterlab-IOS, Erich Jaeger, Germany). If measured data showed an obstruction, a bronchodilatator was inhaled to assess reversibility. When results were normal, a bronchial provocation test, using inhaled metacholine, was performed. Skin prick tests (SPTs) were performed during the first exam, and at 24 and 36 months (Stallergenes-DHS). Collection of data was largely incomplete due to a number of patients lost of follow up. Based on the available data, it can be conclude that most of lung tests results were in the normal range but a non negligible bronchial hyper reactivity was documented (41% of patients). This study must be continued to increase the number of included patients and to continue their follow up during a longer time.

Conditions

Bronchiolitis

Outcome Measures

Primary Outcomes (2)

• Body plethysmography at least three weeks after the first bronchiolitis episode and at 18 and 24 months

  18, 24, 30 and 36 months

• Respiratory resistances measure (oscillometry and occlusion systems) at 30 and 36 months

  18, 24, 30 and 36 months

Secondary Outcomes (1)

• Skin prick tests

  at the first exam, and at 24 and 36 months

Study Arms (1)

A

OTHER

body plethysmography Same tests were performed at 18 and 24 months. At 30 and 36 months, pulmonary function was evaluated by measuring respiratory resistances using an oscillometry system and an occlusion system

Procedure: body plethysmography

Interventions

body plethysmography PROCEDURE

Same tests were performed at 18 and 24 months. At 30 and 36 months, pulmonary function was evaluated by measuring respiratory resistances using an oscillometry system and an occlusion system

A

Eligibility Criteria

• Age: 3 Months - 32 Months
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• child under 32 months old
• child suffering from bronchiolitis episode at least 3 weeks before beginning the study

You may not qualify if:

• child over 32 months old
• child suffering from bronchiolitis episode since less than 3 weeks

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Nice: lead

Study Sites (1)

CRENESSE Dominique

Nice, 06000, France

Location

Related Publications (7)

• Wright AL, Taussig LM, Ray CG, Harrison HR, Holberg CJ. The Tucson Children's Respiratory Study. II. Lower respiratory tract illness in the first year of life. Am J Epidemiol. 1989 Jun;129(6):1232-46. doi: 10.1093/oxfordjournals.aje.a115243.

  PMID: 2729259 BACKGROUND

• Sigurs N, Gustafsson PM, Bjarnason R, Lundberg F, Schmidt S, Sigurbergsson F, Kjellman B. Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13. Am J Respir Crit Care Med. 2005 Jan 15;171(2):137-41. doi: 10.1164/rccm.200406-730OC. Epub 2004 Oct 29.

  PMID: 15516534 BACKGROUND

• Van Bever HP, Wieringa MH, Weyler JJ, Nelen VJ, Fortuin M, Vermeire PA. Croup and recurrent croup: their association with asthma and allergy. An epidemiological study on 5-8-year-old children. Eur J Pediatr. 1999 Mar;158(3):253-7. doi: 10.1007/s004310051062.

  PMID: 10094451 BACKGROUND

• Schauer U, Hoffjan S, Bittscheidt J, Kochling A, Hemmis S, Bongartz S, Stephan V. RSV bronchiolitis and risk of wheeze and allergic sensitisation in the first year of life. Eur Respir J. 2002 Nov;20(5):1277-83. doi: 10.1183/09031936.02.00019902.

  PMID: 12449185 BACKGROUND

• Stein RT, Sherrill D, Morgan WJ, Holberg CJ, Halonen M, Taussig LM, Wright AL, Martinez FD. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet. 1999 Aug 14;354(9178):541-5. doi: 10.1016/S0140-6736(98)10321-5.

  PMID: 10470697 BACKGROUND

• Sampson HA, Albergo R. Comparison of results of skin tests, RAST, and double-blind, placebo-controlled food challenges in children with atopic dermatitis. J Allergy Clin Immunol. 1984 Jul;74(1):26-33. doi: 10.1016/0091-6749(84)90083-6.

  PMID: 6547461 BACKGROUND

• Capasso G, Jaeger P, Robertson WG, Unwin RJ. Uric acid and the kidney: urate transport, stone disease and progressive renal failure. Curr Pharm Des. 2005;11(32):4153-9. doi: 10.2174/138161205774913219.

  PMID: 16375737 RESULT

MeSH Terms

Conditions

Bronchiolitis

Condition Hierarchy (Ancestors)

Bronchitis; Respiratory Tract Infections; Infections; Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases

Study Officials

• Dominique CRENESSE, PU PH

  Centre Hospitalier Universitaire de Nice

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 12, 2008
• First Posted: May 13, 2008
• Study Start: January 1, 2004
• Primary Completion: June 1, 2007
• Study Completion: June 1, 2007
• Last Updated: March 31, 2026

Record last verified: 2026-03

Locations

FR (1)