Angiogenesis With Positron Emission Tomography (PET) Tracer Uptake

NCT00671242 | Completed DMC

• 1 other identifier: kkaira1970
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

Purpose: L-\[3-18F\]-α-methyltyrosine (18F-FMT) is an amino-acid tracer for PET. We have conducted a clinicopathologic study to elucidate the correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in the patients with non-small cell lung cancer (NSCLC). Method: Thirty-seven NSCLC patients were enrolled in this study, and a pair of PET study with 18F-FMT and 18F-FDG was performed. Uptake of PET tracers was evaluated with standardized uptake value. VEGF, CD31, CD34, LAT1 and Ki-67 labeling index of the resected tumors were analyzed by immunohistochemical staining, and correlated with the clinicopathologic variables and the uptake of PET tracers.

Conditions

Angiogenesis; Non-Small Cell Lung Cancer

Keywords

Fluorine-18-α-methyltyrosine,; Positron emission tomography,; Fluorine-18-fluorodeoxyglucose,; Lung cancer,; Angiogenesis; The median VEGF rate was 45% (range, 10-78%).; High expression was seen in 30 patients (81%, 30/37).; VEGF expression was statistically associated with progressively growing microvessel count.

Study Arms (2)

I

L-\[3-18F\]-α-methyltyrosine (18F-FMT) is an amino-acid tracer for PET. We have conducted a clinicopathologic study to elucidate the correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in the patients with non-small cell lung cancer

Nuclear

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients who underwent a thoracotomy within 4 weeks after 18F-FMT PET and 18F-FDG PET study
• Histology is non-small cell lung cancer

You may not qualify if:

• Patient who received neoadjuvant chemotherapy or radiotherapy before surgery
• Patients who have insulin-dependent diabetes

Sponsors & Collaborators

• Gunma University: lead
• J~pharma: collaborator

Study Sites (1)

Gunma University Graduate School of Medicine

Showa-machi, Maebashi, Gunma, 371-8511, Japan

Location

Related Publications (1)

• Kaira K, Oriuchi N, Shimizu K, Ishikita T, Higuchi T, Imai H, Yanagitani N, Sunaga N, Hisada T, Ishizuka T, Kanai Y, Endou H, Nakajima T, Endo K, Mori M. Correlation of angiogenesis with 18F-FMT and 18F-FDG uptake in non-small cell lung cancer. Cancer Sci. 2009 Apr;100(4):753-8. doi: 10.1111/j.1349-7006.2008.01077.x. Epub 2009 Jan 12.

  PMID: 19141127 DERIVED

MeSH Terms

Conditions

Carcinoma, Non-Small-Cell Lung; Lung Neoplasms

Condition Hierarchy (Ancestors)

Carcinoma, Bronchogenic; Bronchial Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: April 30, 2008
• First Posted: May 5, 2008
• Last Updated: May 5, 2008

Record last verified: 2008-01

Locations

JP (1)