Protocol for Evaluation of Quarter-Time Cardiac Imaging: 5-Minutes Rest and 3-Minutes Stress Wide Beam Reconstruction (WBR) Versus Full-Time Filtered Back Projection (FBP)
Quarter-Time Myocardial Perfusion SPECT
1 other identifier
observational
134
0 countries
N/A
Brief Summary
A new, innovative software image processing method, wide beam reconstruction (WBR), utilizes resolution recovery and incorporates Poisson noise-reduction into the reconstruction process of NM images. This method facilitates the reconstruction of low count density myocardial perfusion SPECT images. Preliminary research indicates that SPECT acquisition time consequently can be reduced by 60% (less than 5 minutes) for rest and by 75% (just over 3 minutes) for stress, while tomographic image quality is maintained, or even improved. Such a decrease in image acquisition time decreases patient discomfort during the tomographic acquisition, decreases the opportunity for patient motion, and improves laboratory efficiency.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started May 2007
Shorter than P25 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2007
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2008
CompletedFirst Submitted
Initial submission to the registry
April 8, 2008
CompletedFirst Posted
Study publicly available on registry
April 18, 2008
CompletedAugust 26, 2008
August 1, 2008
3 months
April 8, 2008
August 25, 2008
Conditions
Outcome Measures
Primary Outcomes (1)
Image quality of quarter-time WBR images is equivalent/superior to full-time FBP
March 2008
Secondary Outcomes (1)
Image quality of quarter-time WBR is equivalent/superior to half-time WBR
March 2008
Study Arms (4)
FBP studies
standard filtered backprojection image processing/reconstruction of full-time acquisition data
half-time WBR
wide-beam reconstruction of simulated half-time acquisitions from standard full-time acquisitions
Quarter-time stress
4 seconds per stop post-stress SPECT acquisitions reconstructed by the wide-beam reconstruction method
Quarter-time rest
6 seconds per stop rest SPECT acquisitions reconstructed by the wide-beam reconstruction method
Interventions
Comparison of the diagnostic quality of quarter-time WBR stress with stress studies generated via FBP and half-time WBR
Comparison of the diagnostic quality of 6 SPS quarter-time rest acquisitions with FBP and half-time WBR rest studies; simulated 8 SPS and 10 SPS quarter-time rest acquisitions are also compared to FBP and half-time WBR rest studies.
Eligibility Criteria
Adult male and female patients referred to St. Luke's NM lab. for clinically indicated myocardial perfusion SPECT
You may qualify if:
- Patient is clinically stable
- Patient is able to tolerate additional 8 minutes of scanning
- Patient is willing to undergo additional 8 minutes of scanning
You may not qualify if:
- Unstable patient
- Non-consenting patient
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Gordon DePuey, MD
St. Luke's-Roosevelt Hospital Center
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
April 8, 2008
First Posted
April 18, 2008
Study Start
May 1, 2007
Primary Completion
August 1, 2007
Study Completion
January 1, 2008
Last Updated
August 26, 2008
Record last verified: 2008-08