Comparison of Blood Pressure Medications on Metabolism
Carvedilol vs.Metoprolol: A Comparison of Effects on Endothelial Function and Oxidative Stress in Response to Acute Hyperglycemia in Patients With Type 2 Diabetes and Hypertension
1 other identifier
interventional
22
1 country
1
Brief Summary
The purpose of this study is to determine if there are differences, (benefits) between carvedilol and metoprolol in the treatment of HTN in patients with type 2 diabetes. Specifically we will be looking at differences in blood pressure and blood sugar control, endothelial function, inflammation, oxidative stress and coagulation. Subjects will be randomized to one of the two beta-blockers and followed for 5 months. Each subject will undergo 4 inpatient studies where an oral glucose tolerance test will be done, Inflammatory and oxidative stress markers will be measured. Endothelial function will be measured using brachial artery ultrasound and laser skin Doppler
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for phase_4 diabetes
Started Jan 2004
Longer than P75 for phase_4 diabetes
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2004
CompletedFirst Submitted
Initial submission to the registry
March 21, 2008
CompletedFirst Posted
Study publicly available on registry
March 25, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2008
CompletedResults Posted
Study results publicly available
December 26, 2023
CompletedDecember 26, 2023
December 1, 2023
4.4 years
March 21, 2008
April 11, 2012
December 7, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Number of Participants Assessed for Change in Markers of Inflammation (PAI-1) Following Treatment Compared to Baseline
Reporting the number of participants with a change in markers of inflammation (PAI-1) following treatment compared to baseline.
5 months
Study Arms (2)
1
ACTIVE COMPARATORstudy drug- carvedilol
2
ACTIVE COMPARATORstudy drug metorprolol
Interventions
Eligibility Criteria
You may qualify if:
- not enrolling
You may not qualify if:
- not enrolling
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
UNMHSC
Albuquerque, New Mexico, 87131, United States
Related Publications (1)
Colleran K, Aguirre L, Burge MR. Carvedilol vs. metoprolol: A comparison of effects on endothelial function and oxidative stress in response to acute hyperglycemia in patients with type 2 diabetes and hypertension. Journal of Diabetes Mellitus 2(1):146-151, 2012.
RESULT
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Dr. Kathleen Colleran
- Organization
- University of New Mexico Health Sciences Center
Publication Agreements
- PI is Sponsor Employee
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- DIAGNOSTIC
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 21, 2008
First Posted
March 25, 2008
Study Start
January 1, 2004
Primary Completion
June 1, 2008
Study Completion
July 1, 2008
Last Updated
December 26, 2023
Results First Posted
December 26, 2023
Record last verified: 2023-12