NCT00060931

Brief Summary

Evaluation of the effect of two different antihypertensive treatments on control of glucose in Type II diabetic patients with high blood pressure

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
501

participants targeted

Target at P75+ for phase_4 hypertension

Timeline
Completed

Started Jun 2001

Typical duration for phase_4 hypertension

Geographic Reach
1 country

119 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2001

Completed
2 years until next milestone

First Submitted

Initial submission to the registry

May 15, 2003

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 16, 2003

Completed
11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2004

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2004

Completed
Last Updated

April 14, 2015

Status Verified

April 1, 2015

Enrollment Period

2.8 years

First QC Date

May 15, 2003

Last Update Submit

April 13, 2015

Conditions

Keywords

hypertensionbeta-blockersType 2 diabetes

Outcome Measures

Primary Outcomes (1)

  • Change from baseline in HbA1c at 5 months

    5 months

Secondary Outcomes (1)

  • Blood pressure at 3 and 5 months Body weight at 3 and 5 months Lab levels (glucose, insulin, triglycerides, cholesterol, and albumin:creatinine ratio) at 3 and 5 months.

    5 months

Interventions

Also known as: carvedilol

Eligibility Criteria

Age30 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients at screening must be insulin producing Type II diabetics (C peptide positive).
  • Patients must have a history of mild to moderate hypertension (140-179 systolic blood pressure; 90-1-9 diastolic blood pressure)
  • Patients must be on a stable regimen of ACE (angiotensin converting enzyme) / ARB (angiotensin receptor blocker) treatment alone or in combination with other treatments.
  • Patients must be on stable antidiabetic regimen (drug treated or diet alone).
  • Patient''s laboratory result for HbA1c must be 6.5 - 8.5 (drug treated) or 6.5 - 7.5 (diet alone).

You may not qualify if:

  • Patients using beta-blocker therapy.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (119)

GSK Investigational Site

Birmingham, Alabama, 35211, United States

Location

GSK Investigational Site

Birmingham, Alabama, 35294-0012, United States

Location

GSK Investigational Site

Birmingham, Alabama, 35294-2041, United States

Location

GSK Investigational Site

Columbia, Alabama, 35051, United States

Location

GSK Investigational Site

Mobile, Alabama, 36608, United States

Location

GSK Investigational Site

Derby, Connecticut, 06418, United States

Location

GSK Investigational Site

Farmington, Connecticut, 06030 - 1410, United States

Location

GSK Investigational Site

Hartford, Connecticut, 06106, United States

Location

GSK Investigational Site

New Britain, Connecticut, 06050, United States

Location

GSK Investigational Site

Newark, Delaware, 19713, United States

Location

GSK Investigational Site

Washington D.C., District of Columbia, 20037, United States

Location

GSK Investigational Site

Washington D.C., District of Columbia, 20422, United States

Location

GSK Investigational Site

Coral Gables, Florida, 33134, United States

Location

GSK Investigational Site

Fort Lauderdale, Florida, 33308, United States

Location

GSK Investigational Site

Fort Lauderdale, Florida, 33316, United States

Location

GSK Investigational Site

Fort Meyers, Florida, 33907, United States

Location

GSK Investigational Site

Gainesville, Florida, 32605, United States

Location

GSK Investigational Site

Hollywood, Florida, 33021, United States

Location

GSK Investigational Site

Hollywood, Florida, 33023, United States

Location

GSK Investigational Site

Inverness, Florida, 34452, United States

Location

GSK Investigational Site

Jacksonville, Florida, 32205, United States

Location

GSK Investigational Site

Jacksonville, Florida, 32216, United States

Location

GSK Investigational Site

Melbourne, Florida, 32901, United States

Location

GSK Investigational Site

Miami, Florida, 33133, United States

Location

GSK Investigational Site

Miami, Florida, 33136, United States

Location

GSK Investigational Site

Miami, Florida, 33156, United States

Location

GSK Investigational Site

Miami, Florida, 33176, United States

Location

GSK Investigational Site

Ocala, Florida, 34471, United States

Location

GSK Investigational Site

Ocala, Florida, 34474, United States

Location

GSK Investigational Site

Pembroke Pines, Florida, 33024, United States

Location

GSK Investigational Site

Saint Petersberg, Florida, 33705, United States

Location

GSK Investigational Site

Sarasota, Florida, 34239, United States

Location

GSK Investigational Site

Tamarac, Florida, 33321, United States

Location

GSK Investigational Site

Tampa, Florida, 33614, United States

Location

GSK Investigational Site

Augusta, Georgia, 30901, United States

Location

GSK Investigational Site

Fayetteville, Georgia, 30214, United States

Location

GSK Investigational Site

Lawrenceville, Georgia, 30045, United States

Location

GSK Investigational Site

Savannah, Georgia, 31406, United States

Location

GSK Investigational Site

Chicago, Illinois, 60616, United States

Location

GSK Investigational Site

West Evanston, Illinois, 60202, United States

Location

GSK Investigational Site

Newburgh, Indiana, 47630, United States

Location

GSK Investigational Site

Wabash, Indiana, 46992, United States

Location

GSK Investigational Site

Lexington, Kentucky, 40508, United States

Location

GSK Investigational Site

New Orleans, Louisiana, 70112, United States

Location

GSK Investigational Site

New Orleans, Louisiana, 70121, United States

Location

GSK Investigational Site

Auburn, Maine, 04210, United States

Location

GSK Investigational Site

Bangor, Maine, 04401, United States

Location

GSK Investigational Site

Baltimore, Maryland, 21204, United States

Location

GSK Investigational Site

Baltimore, Maryland, 21208, United States

Location

GSK Investigational Site

Ayer, Massachusetts, 01432, United States

Location

GSK Investigational Site

Boston, Massachusetts, 02115, United States

Location

GSK Investigational Site

Haverhill, Massachusetts, 01831-2451, United States

Location

GSK Investigational Site

Springfield, Massachusetts, 01107, United States

Location

GSK Investigational Site

Waltham, Massachusetts, 02453, United States

Location

GSK Investigational Site

Worcester, Massachusetts, 01605, United States

Location

GSK Investigational Site

Worcester, Massachusetts, 01610, United States

Location

GSK Investigational Site

Waterford, Michigan, 48328, United States

Location

GSK Investigational Site

Gulfport, Mississippi, 39501, United States

Location

GSK Investigational Site

Camden, New Jersey, 08103, United States

Location

GSK Investigational Site

Hackensack, New Jersey, 07601, United States

Location

GSK Investigational Site

Linwood, New Jersey, 08221, United States

Location

GSK Investigational Site

Margate City, New Jersey, 08402, United States

Location

GSK Investigational Site

Sea Girt, New Jersey, 08750, United States

Location

GSK Investigational Site

Voorhees Township, New Jersey, 08043, United States

Location

GSK Investigational Site

Buffalo, New York, 14209, United States

Location

GSK Investigational Site

Flushing, New York, 11365, United States

Location

GSK Investigational Site

Fulton, New York, 13069, United States

Location

GSK Investigational Site

Kingston, New York, 12401, United States

Location

GSK Investigational Site

Lancaster, New York, 14043, United States

Location

GSK Investigational Site

Liverpool, New York, 13088, United States

Location

GSK Investigational Site

New Hyde Park, New York, 11040, United States

Location

GSK Investigational Site

New York, New York, 10021, United States

Location

GSK Investigational Site

New York, New York, 10028, United States

Location

GSK Investigational Site

New York, New York, 10032, United States

Location

GSK Investigational Site

Rochester, New York, 14609, United States

Location

GSK Investigational Site

Scarsdale, New York, 10583, United States

Location

GSK Investigational Site

Syracuse, New York, 13202, United States

Location

GSK Investigational Site

The Bronx, New York, 10461, United States

Location

GSK Investigational Site

The Bronx, New York, 10467, United States

Location

GSK Investigational Site

Tonawanda, New York, 14150, United States

Location

GSK Investigational Site

Williamsville, New York, 14221, United States

Location

GSK Investigational Site

Durham, North Carolina, 27710, United States

Location

GSK Investigational Site

Hickory, North Carolina, 28601, United States

Location

GSK Investigational Site

Raleigh, North Carolina, 27609, United States

Location

GSK Investigational Site

Statesville, North Carolina, 28677, United States

Location

GSK Investigational Site

Wilmington, North Carolina, 28412, United States

Location

GSK Investigational Site

Winston-Salem, North Carolina, 27103, United States

Location

GSK Investigational Site

Canton, Ohio, 44708, United States

Location

GSK Investigational Site

Cincinnati, Ohio, 45246, United States

Location

GSK Investigational Site

Cleveland, Ohio, 44106, United States

Location

GSK Investigational Site

Columbus, Ohio, 43212, United States

Location

GSK Investigational Site

Zanesville, Ohio, 43701, United States

Location

GSK Investigational Site

Camp Hill, Pennsylvania, 17011, United States

Location

GSK Investigational Site

Connellsville, Pennsylvania, 15425, United States

Location

GSK Investigational Site

Downington, Pennsylvania, 19335, United States

Location

GSK Investigational Site

Erie, Pennsylvania, 16505, United States

Location

GSK Investigational Site

Fleetwood, Pennsylvania, 19522, United States

Location

GSK Investigational Site

Morrisville, Pennsylvania, 19067, United States

Location

GSK Investigational Site

Philadelphia, Pennsylvania, 19104, United States

Location

GSK Investigational Site

Philadelphia, Pennsylvania, 19107, United States

Location

GSK Investigational Site

Philipsburg, Pennsylvania, 16966, United States

Location

GSK Investigational Site

Pittsburgh, Pennsylvania, 15206, United States

Location

GSK Investigational Site

Pittsburgh, Pennsylvania, 15241, United States

Location

GSK Investigational Site

West Grove, Pennsylvania, 19390, United States

Location

GSK Investigational Site

Columbia, South Carolina, 29201, United States

Location

GSK Investigational Site

Greer, South Carolina, 29651, United States

Location

GSK Investigational Site

Summerville, South Carolina, 29485, United States

Location

GSK Investigational Site

Bristol, Tennessee, 37620, United States

Location

GSK Investigational Site

Jackson, Tennessee, 38301, United States

Location

GSK Investigational Site

Memphis, Tennessee, 38163, United States

Location

GSK Investigational Site

Nashville, Tennessee, 37212, United States

Location

GSK Investigational Site

White River Junction, Utah, 05009, United States

Location

GSK Investigational Site

Christiansburg, Virginia, 24073, United States

Location

GSK Investigational Site

Falls Church, Virginia, 22044, United States

Location

GSK Investigational Site

Fredericksburg, Virginia, 20401, United States

Location

GSK Investigational Site

Richmond, Virginia, 23220, United States

Location

GSK Investigational Site

Richmond, Virginia, 23294, United States

Location

GSK Investigational Site

Salem, Virginia, 24153, United States

Location

GSK Investigational Site

Springfield, Virginia, 22151, United States

Location

MeSH Terms

Conditions

HypertensionDiabetes Mellitus, Type 2

Interventions

CarvedilolMetoprolol

Condition Hierarchy (Ancestors)

Vascular DiseasesCardiovascular DiseasesDiabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Intervention Hierarchy (Ancestors)

PropanolaminesAmino AlcoholsAlcoholsOrganic ChemicalsPropanolsAminesCarbazolesIndolesHeterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-RingHeterocyclic CompoundsHeterocyclic Compounds, 3-RingPhenoxypropanolamines

Study Officials

  • GSK Clinical Trials

    GlaxoSmithKline

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 4
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 15, 2003

First Posted

May 16, 2003

Study Start

June 1, 2001

Primary Completion

April 1, 2004

Study Completion

April 1, 2004

Last Updated

April 14, 2015

Record last verified: 2015-04

Locations