Success Metrics

Clinical Success Rate
88.9%

Based on 56 completed trials

Completion Rate
89%(56/63)
Active Trials
18(14%)
Results Posted
36%(20 trials)
Terminated
7(5%)

Phase Distribution

Ph not_applicable
25
19%
Ph early_phase_1
3
2%
Ph phase_4
51
39%
Ph phase_1
13
10%
Ph phase_2
18
14%
Ph phase_3
15
12%

Phase Distribution

16

Early Stage

18

Mid Stage

66

Late Stage

Phase Distribution125 total trials
Early Phase 1First-in-human
3(2.4%)
Phase 1Safety & dosage
13(10.4%)
Phase 2Efficacy & side effects
18(14.4%)
Phase 3Large-scale testing
15(12.0%)
Phase 4Post-market surveillance
51(40.8%)
N/ANon-phased studies
25(20.0%)

Highest Phase Reached

Phase 4

Trial Status & Enrollment

Completion Rate

77.8%

56 of 72 finished

Non-Completion Rate

22.2%

16 ended early

Currently Active

18

trials recruiting

Total Trials

130

all time

Status Distribution
Active(25)
Completed(56)
Terminated(16)
Other(33)

Detailed Status

Completed56
unknown33
Recruiting13
Withdrawn9
Terminated7
Not yet recruiting6

Development Timeline

Analytics

Development Status

Total Trials
130
Active
18
Success Rate
88.9%
Most Advanced
Phase 4

Trials by Phase

Early Phase 13 (2.4%)
Phase 113 (10.4%)
Phase 218 (14.4%)
Phase 315 (12.0%)
Phase 451 (40.8%)
N/A25 (20.0%)

Trials by Status

active_not_recruiting54%
not_yet_recruiting65%
withdrawn97%
completed5643%
recruiting1310%
terminated75%
enrolling_by_invitation11%
unknown3325%

Recent Activity

Clinical Trials (130)

Showing 20 of 130 trialsScroll for more
NCT05194111Phase 1

Treating Heart Dysfunction Related to Cancer Therapy With Sacubitril/Valsartan

Recruiting
NCT03879629Phase 2

Treating Breast Cancer Patients Undergoing Trastuzumab Treatment With Carvedilol to Reduce Incidence of Heart Failure

Terminated
NCT05553314Phase 4

Carvedilol in HF With Preserved EF

Completed
NCT07322237Phase 4

DICE Study- Diastolic Improvement With Carvedilol & Empagliflozin in Patients With Cirrhosis

Recruiting
NCT06844669Phase 2

HER2HEART-US: Prevention of Cardiotoxicity in Breast Cancer Patients Receiving HER2-directed Therapy

Terminated
NCT05872698Phase 4

Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of Oesophageal Varices Trial.

Active Not Recruiting
NCT07521332Phase 4

Apixaban-PK Trial: Preventing Portal Hypertension Complications in Cirrhosis

Recruiting
NCT07465471Not Applicable

Carvedilol and Midodrine Versus Carvedilol Alone in Preventing Early Rebleed in Patients With Cirrhosis.

Not Yet Recruiting
NCT06566794Not Applicable

KF2022#4-trial: Effects of a Beta Blocker and NSAID on CYP Mediated Drug Metabolism

Completed
NCT03775096Phase 2

Adrenergic Blockers for Cardiac Changes in Early Parkinson's Disease (Protocol 53136)

Active Not Recruiting
NCT04218968Phase 2

Cardiac Changes in Early Parkinson's Disease: A Follow up Study

Active Not Recruiting
NCT07352228Phase 4

Carvedilol vs. Propranolol for Preventing Rebleeding After Endoscopic Treatment of Cirrhotic Varices

Enrolling By Invitation
NCT05931276Phase 3

CSP #2026 - Beta Blocker Dialyzability on Cardiovascular Outcomes

Recruiting
NCT04023110Phase 1

Risk-Guided Cardioprotection With Carvedilol in Breast Cancer Patients Treated With Doxorubicin and/or Trastuzumab

Completed
NCT03418961Phase 3

S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

Recruiting
NCT01261065Phase 4

Mechanisms of Improvement With Beta-Blocker Treatment in Heart Failure

Completed
NCT06861075Not Applicable

CARPEUS : Effect of Carvedilol on the Portosystemic Gradient as Measured by Endoscopic Ultrasound

Recruiting
NCT06964464Phase 4

Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator

Recruiting
NCT01212250Not Applicable

Carvedilol for Pre-primary Prophylaxis of Esophageal Varices in Cirrhosis

Recruiting
NCT07108075Not Applicable

Acute Portal Pressure Reduction by Metformin and Carvedilol Compared to Carvedilol Alone in Cirrhosis.

Recruiting

Drug Details

Intervention Type
DRUG
Total Trials
130