Intraoperative Optical Imaging of Brain Function

NCT00632437 | Withdrawn

• 1 other identifier: 2006-0102
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this proposal is to test the performance of a novel optical imaging system for real-time quantitative imaging of brain function through multiple hemodynamic measures during neurosurgery. This pilot study encompasses two sub-aims:

• Evaluate the ability of laser speckle contrast imaging to image cerebral blood flow (CBF) intraoperatively. We will image the changes in CBF in response to somatosensory stimulation. (5 patients).
• Simultaneously image hemoglobin oxygenation, blood volume, blood flow, and cerebral metabolic rate of oxygen (CMRO2) changes during somatosensory stimulation using a combined laser speckle and multi-wavelength reflectance imaging system. (5 patients).

Conditions

Brain Tumor

Keywords

Brain Tumor; Craniotomy Surgery; Brain Function; Intraoperative Optical Imaging; Speckle-Contrast Imaging; Cortical Mapping; Somatosensory Cortex; Cerebral blood flow; CBF; Laser Speckle Contrast Imaging; Multi-Spectral Imaging

Outcome Measures

Primary Outcomes (1)

• Test performance of novel optical imaging system for real-time quantitative imaging of brain function through multiple hemodynamic measures during neurosurgery

  2 Years

Study Arms (1)

Speckle-Contrast Imaging

Procedure: Speckle-Contrast Imaging

Interventions

Speckle-Contrast Imaging PROCEDURE

Imaging camera scan that uses reflected red light to take pictures of the amount of blood flowing in brain and the amount of oxygen in blood.

Speckle-Contrast Imaging

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients having a brain tumor which is scheduled to be surgically removed.

You may qualify if:

• Location of planned resection near somatosensory cortex.
• Planned intraoperative electrocortical mapping.
• Able to render written informed consent.

You may not qualify if:

• Patients with a hemiparesis graded 3/5 (active movement against gravity) or worse. Unpublished data from MDACC Department of Neurosurgery suggests that cortical mapping is ineffective in these patients because an adequate cortical response is not detected
• Patients with a vascular malformation within the proximity of the cortex area imaged.

Sponsors & Collaborators

• M.D. Anderson Cancer Center: lead
• National Institutes of Health (NIH): collaborator
• National Institute of Neurological Disorders and Stroke (NINDS): collaborator

Study Sites (1)

U.T.M.D. Anderson Cancer Center

Houston, Texas, 77030, United States

Location

Related Links

• UT MD Anderson Cancer Center Website

MeSH Terms

Conditions

Brain Neoplasms

Interventions

Laser Speckle Contrast Imaging

Condition Hierarchy (Ancestors)

Central Nervous System Neoplasms; Nervous System Neoplasms; Neoplasms by Site; Neoplasms; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Optical Imaging; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques

Study Officials

• Jeffrey Weinberg, MD

  M.D. Anderson Cancer Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 13, 2008
• First Posted: March 10, 2008
• Study Start: February 1, 2008
• Primary Completion: June 1, 2010
• Study Completion: June 1, 2010
• Last Updated: July 30, 2012

Record last verified: 2012-07

Locations

US (1)