Velocity Vector Imaging in Patients With Moderate-to-Severe Aortic Regurgitation
1 other identifier
observational
50
1 country
1
Brief Summary
Velocity Vector Imaging may provide reliable and detailed information on left ventricular segmental function in asymptomatic patients with moderate-to severe AR. This may help to identify subclinical myocardial dysfunction in order to operate early enough to prevent postoperative heart failure and restrict unnecessary early operation which could be associated with operative risks and mortality related to prosthetic valves.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Mar 2008
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 19, 2008
CompletedFirst Posted
Study publicly available on registry
February 28, 2008
CompletedStudy Start
First participant enrolled
March 1, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2008
CompletedJune 30, 2008
June 1, 2008
1 month
February 19, 2008
June 27, 2008
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Velocity Vector Imaging derived segmental systolic peak Strain and Strain rates
April 2008
Study Arms (2)
A
Patients with moderate-to-severe aortic regurgitation having normal left ventricular ejection fraction
B
Age, sex and bodymass index matched healthy subjects
Eligibility Criteria
Tertiary care clinic
You may qualify if:
- Moderate-to-severe aortic regurgitation identified by Standard echocardiography.
- Chronic isolated aortic regurgitation
- Being asymptomatic ( Class 1 according to NYHA)
- Sinusal rhythm
You may not qualify if:
- Ejection fraction \< 50%
- Mitral valve disease accompanied to aortic regurgitation (patients with over mild degree of mitral regurgitation and stenosis
- Aortic stenosis
- Previous myocardial infarction, or the patients with \>50% coronary occlusion in any of the coronary arteries.
- Cardiomyopathies
- AV conduction disorders
- Chronic renal or hepatic insufficiency
- Malignities
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
TC.Istanbul Bilim University, Florence Nightingale Hospital, Division of Cardiology
Istanbul, Sisli, 34381, Turkey (Türkiye)
Related Publications (1)
Sokmen G, Sokmen A, Duzenli A, Soylu A, Ozdemir K. Assessment of myocardial velocities and global function of the left ventricle in asymptomatic patients with moderate-to-severe chronic aortic regurgitation: a tissue Doppler echocardiographic study. Echocardiography. 2007 Jul;24(6):609-14. doi: 10.1111/j.1540-8175.2007.00438.x.
PMID: 17584200BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Saide Aytekin, Professor
T.C. Istanbul Bilim University, Florence Nightingale Hospital, Division of Cardiology
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
February 19, 2008
First Posted
February 28, 2008
Study Start
March 1, 2008
Primary Completion
April 1, 2008
Study Completion
May 1, 2008
Last Updated
June 30, 2008
Record last verified: 2008-06