Assessment of Left Ventricular Torsion by Echocardiography Study

NCT00589836 | Completed Results

• 1 other identifier: IRB 05-023
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to learn about the twisting or wringing motion of the heartbeat called Left Ventricular Torsion (LV Torsion) which can be seen on ultrasound.

Conditions

Hypertrophic Cardiomyopathy

Keywords

HCM; HOCM; hypertrophic cardiomyopathy; tissue doppler echocardiography; myocardial torsion

Outcome Measures

Primary Outcomes (1)

• Accuracy of Doppler Tissue Imaging

  The purpose of the present study was to examine the accuracy of a novel method with DTI for quantifying the LV torsion in humans and tagged MRI as the reference standard. LV torsion reflects the torsion (twisting deformation) occurring across the length of the ventricle (from the base to the apex) during the time interval defined by the beginning and end of contraction (or in physiologic terms, from end -diastole to end systole). In this study, end diastole was defined by the R wave of the ECG, while end systole is defined by minimum end-systolic volume or maximum of twisting deformation. The deformation is measured in degrees. Once the measurements are performed by experimental method (i.e. TDI imaging) and reference method (i.e. MRI imaging) these two methods are then compared using Bland Altman analysis. In a current study, mean difference between methods of torsion quantification was 0.57 degrees, while the standard deviation (SD) was 1.98 degrees.

  1 1/2 hours

Study Arms (1)

Cardiac Pathologies

Patients with cardiomyopathy, ischemic heart disease, will have tissue Doppler echocardiograms performed

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients undergoing cardiac echocardiography testing in the outpatient department

You may qualify if:

• Male and female patients age 18 to 70 years
• Patients with hypertrophic cardiomyopathy
• Patients with the ability to exercise using a supine bicycle
• Ability to provide informed consent

You may not qualify if:

• Aortic valve stenosis classified as moderate to severe
• Severe left ventricular obstruction at rest (high gradients \> 4m/second)
• Uncontrolled arrhythmias including atrial fibrillation, atrial flutter, frequent premature ventricular ectopic beats
• History of sustained ventricular tachyarrhythmia at any time

Sponsors & Collaborators

• The Cleveland Clinic: lead

Study Sites (1)

The Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States

Location

MeSH Terms

Conditions

Cardiomyopathy, Hypertrophic

Condition Hierarchy (Ancestors)

Cardiomyopathies; Heart Diseases; Cardiovascular Diseases; Aortic Stenosis, Subvalvular; Aortic Valve Stenosis; Aortic Valve Disease; Heart Valve Diseases

Results Point of Contact

• Title: Zoran Popovic MD
• Organization: Cleveland Clinic

popoviz@ccf.org

216 444-9242

Study Officials

• Zoran Popovic, M.D.

  The Cleveland Clinic

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: December 26, 2007
• First Posted: January 10, 2008
• Study Start: June 1, 2005
• Primary Completion: April 1, 2008
• Study Completion: April 1, 2008
• Last Updated: February 5, 2018
• Results First Posted: February 5, 2018

Record last verified: 2017-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)