Wisconsin Brain Donor Program

NCT00585572 | Enrolling By Invitation

• 6 other identifiers: H-2010-00372014-1484A534255GERIATRICS AND ADULT2RF1AG027161-11A11P30AG062715-01
• Study Type: observational
• Target: 9,999
• Locations: 1 country
• Sites: 1

Brief Summary

The Wisconsin Brain Donor Program (WBDP) stores brain and other tissues/samples (e.g. blood and CSF) from deceased individuals who have participated in longitudinal research studies, as well as other select participants. These individuals have donated their tissues in order to aid scientific research. Through the collection of central and peripheral nervous tissues as well as (in select cases) skeletal muscle tissue, the WBDP strives to advance the knowledge of diseases of memory disorders, such as Alzheimer's Disease. Brain donations are needed from healthy individuals, as well as those affected by diseases of the nervous system.

Conditions

Alzheimer's Disease; Mild Cognitive Impairment

Keywords

Normal Tissues/Brains; Alzheimer; Motor Neuron Disease; Dementia; Healthy Control Volunteers; Populations At Risk; MCI

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants agree to autopsy and brain/tissue/sample donation for research purposes only.

You may qualify if:

• Is aged 18 years or older
• Falls into one of the following categories:
• Current or previous study participants involved in the ADRC Clinical Core, WRAP study, or other select ADRC-affiliated studies, or donors of special circumstance, including healthy controls, if approved on a case-by-case basis by the WBDP PI. Please note, ADRC-affiliated studies are not inclusive of ADRC-affiliated industry-sponsored studies.
• Is a parent of either an ADRC Clinical Core or WRAP study participant, or is a spouse of a WRAP study participant.

You may not qualify if:

• VA research subjects
• Subjects with a medical condition/disease that would exclude them from the spectrum of utility/interest to researchers as determined by a WBDP Neuropathologist:
• Persons with Hepatitis B or C
• Severe Traumatic Brain Injury
• Positive CJD diagnosis
• Persons with HIV/AIDS
• Persons with brain tumors or blood clots that affect neurologic status, therefore creating a problem between diagnosing AD status and healthy status
• Cancer that has metastasized to the brain
• Radiation treatment to the head
• Other infectious diseases that would be hazardous to staff handling the tissue
• Prolonged ventilator dependency prior to death as determined by the Neuropathologist
• Subjects who lack capacity to provide informed consent with no activated Power of Attorney (POA) for Healthcare, activated POA for Research, or legal guardianship (if not near death), or (if at or near death) have no spouse, parent, relative or friend willing/able to complete consent and other donation paperwork.
• Subjects who otherwise have incomplete history or incomplete donation paperwork before a recovery can begin.
• Subjects younger than 18 years of age.
• Medical conditions that would put researchers at risk.

Sponsors & Collaborators

• University of Wisconsin, Madison: lead
• University of Washington: collaborator
• National Institute on Aging (NIA): collaborator

Study Sites (1)

University of Wisconsin Madison

Madison, Wisconsin, 53792, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Brain tissue, blood, cerebrospinal fluid, spinal cord, peripheral nerves, and skeletal muscles, central/peripheral nervous tissue, as well as skeletal muscle tissue.

MeSH Terms

Conditions

Alzheimer Disease; Cognitive Dysfunction; Motor Neuron Disease; Dementia

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders; Cognition Disorders; Neuromuscular Diseases

Study Officials

• Shahriar Salamat, MD PHD

  University of Wisconsin, Madison

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 26, 2007
• First Posted: January 3, 2008
• Study Start: March 1, 2007
• Primary Completion (Estimated): August 1, 2050
• Study Completion (Estimated): August 1, 2050
• Last Updated: August 8, 2025

Record last verified: 2025-08

Locations

US (1)