Hormonal and Bone Turnover Marker Response to an Acute Bout of Resistance or Plyometric Exercise

NCT00572871 | Completed

• 2 other identifiers: 109723965438
• Study Type: observational
• Target: 12
• Locations: 0 countries
• Sites: N/A

Brief Summary

We are interested in determining if there exist a short-term response in the serum markers and hormones that participate in the regulation of bone tissue formation and breakdown to a single, high-intensity exercise session of weight lifting (resistance exercise) or jumping (plyometrics). We are also interested in determining if the bone marker response to exercise is altered by changing the negative energy state caused by the exercise treatment, when subjects are given a moderate calorie meal.

Conditions

Osteoporosis; Osteopenia

Outcome Measures

Primary Outcomes (1)

• serum bone turnover markers

  24 hours

Secondary Outcomes (1)

• serum hormones regulating bone turnover

  24 hours

Study Arms (3)

Exercise after fasting

Will complete 2 resistance exercise sessions and 2 plyometric exercise sessions after a 10-hour fast

Other: resistance exercise

No exercise

Will complete a ten-hour fast but do no exercise

Other: No exercise

Exercise after snack

Will complete 2 resistance exercise sessions and 2 plyometric exercise sessions 2 hours following a 500 calorie nutritional supplement

Other: plyometric exercise

Interventions

plyometric exercise OTHER

single bout of plyometric exercise

Exercise after snack

resistance exercise OTHER

single bout of resistance exercise

Exercise after fasting

No exercise OTHER

Will not do any exercise

No exercise

Eligibility Criteria

• Age: 25 Years - 65 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Male participants apparently healthy and non-sedentary free of disease that affects bone and not have used or currently use any medication that affects bone.

You may qualify if:

• Male
• No symptoms of disease
• Non-sedentary
• Age 25-65

You may not qualify if:

• Medications or supplements that affect bone metabolism or prevent exercise
• Previous or current medical condition affecting bone health, including osteoporosis.
• Cardiovascular disease
• Metallic implants affecting accuracy of bone density scan
• Current smoker
• Current participation in high-intensity jumping or resistance exercise in the last 3 months.

Sponsors & Collaborators

• University of Missouri-Columbia: lead

Biospecimen

Retention: SAMPLES WITHOUT DNA

serum plasma

MeSH Terms

Conditions

Osteoporosis; Bone Diseases, Metabolic

Interventions

Plyometric Exercise; Resistance Training

Condition Hierarchy (Ancestors)

Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Pamela S Hinton, Ph.D.

  University of Missouri-Columbia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 12, 2007
• First Posted: December 13, 2007
• Study Start: December 1, 2007
• Primary Completion: December 1, 2009
• Study Completion: December 1, 2009
• Last Updated: October 4, 2016

Record last verified: 2016-09

Data Sharing

• IPD Sharing: Will not share