NCT00571649

Brief Summary

This study will evaluate if extended therapy with oral rivaroxaban can prevent blood clots in the leg and lung that can occur with patients hospitalized for acute medical illness, and compare these results with those of the standard enoxaparin dose and duration regimen. The safety of rivaroxaban will also be studied.

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
8,101

participants targeted

Target at P75+ for phase_3

Timeline
Completed

Started Dec 2007

Typical duration for phase_3

Geographic Reach
50 countries

650 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2007

Completed
10 days until next milestone

First Submitted

Initial submission to the registry

December 11, 2007

Completed
1 day until next milestone

First Posted

Study publicly available on registry

December 12, 2007

Completed
2.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2010

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2010

Completed
1.7 years until next milestone

Results Posted

Study results publicly available

June 27, 2012

Completed
Last Updated

September 15, 2016

Status Verified

August 1, 2016

Enrollment Period

2.7 years

First QC Date

December 11, 2007

Results QC Date

February 16, 2012

Last Update Submit

August 3, 2016

Conditions

Keywords

Acute medical illnesses with increased risk for VTE.Deep vein thrombosis (DVT)Pulmonary embolism (PE),Venous Thromboembolic disease (VTE),Medical illness

Outcome Measures

Primary Outcomes (2)

  • Percentage of Participants With Composite Endpoint of Venous Thromboembolism [VTE] (Any Deep Vein Thrombosis [DVT], Non Fatal Pulmonary Embolism [PE]) and VTE-related Death up to Day 35 + 6 Days

    A composite endpoint of: asymptomatic proximal DVT in lower extremity detected by mandatory bilateral lower extremity venous ultrasonography; symptomatic DVT in lower extremity, proximal or distal; symptomatic, non-fatal PE; and VTE-related death.

    Up to Day 35 + 6 days

  • Percentage of Participants With Composite Endpoint of VTE (Any DVT, Non Fatal PE) and VTE-related Death up to Day 10 + 5 Days

    A composite endpoint of: asymptomatic proximal DVT in lower extremity detected by mandatory bilateral lower extremity venous ultrasonography; symptomatic DVT in lower extremity, proximal or distal; symptomatic, non-fatal PE; and VTE-related death.

    Up to Day 10 + 5 days

Secondary Outcomes (12)

  • Percentage of Participants With Composite Endpoint of VTE (Any DVT, Non Fatal PE) and All-cause Mortality up to Day 35 + 6 Days

    Up to Day 35 + 6 days

  • Percentage of Participants With Composite Endpoint of VTE (Any DVT, Non Fatal PE) and VTE-related Death up to Day 10 + 5 Days Per mITT Population

    Up to Day 10 + 5 days

  • Percentage of Participants With VTE Combined With All-cause Mortality up to Day 10 + 5 Days

    Up to Day 10 + 5 days

  • Percentage of Participants With Symptomatic VTE, Including and Excluding VTE-related Death up to Days 10, 35, and 90

    At Day 10 + 5 days, at Day 35 + 6 days, and at Day 90 + 7 days

  • Percentage of Participants With Net Clinical Benefit (Any DVT, Non-fatal PE, VTE-related Death, Plus Major and Clinically Relevant Non-major Bleeding Events) up to Day 35 + 6 Days

    Up to Day 35 + 6 days

  • +7 more secondary outcomes

Study Arms (2)

Rivaroxaban (Xarelto, BAY59-7939)

EXPERIMENTAL

Participants received 10 mg oral rivaroxaban tablet once daily (OD) for 35 +/- 4 days, plus subcutaneous enoxaparin-matched placebo solution OD for 10 +/- 4 days

Drug: Rivaroxaban (Xarelto, BAY59-7939)Drug: Enoxaparin placebo

Enoxaparin

ACTIVE COMPARATOR

Participants received oral rivaroxaban-matched placebo tablet OD for 35 +/- 4 days, plus 40 mg subcutaneous enoxaparin solution OD for 10 +/- 4 days

Drug: EnoxaparinDrug: Rivaroxaban placebo

Interventions

Oral rivaroxaban 10 mg once daily administered for 35 +/- 4 days

Rivaroxaban (Xarelto, BAY59-7939)

Subcutaneous enoxaparin 40 mg once daily (OD) administered for 10 +/- 4 days

Enoxaparin

Oral rivaroxaban-matched placebo tablet OD for 35 +/- 4 days

Enoxaparin

Subcutaneous enoxaparin-matched placebo solution OD for 10 +/- 4 days

Rivaroxaban (Xarelto, BAY59-7939)

Eligibility Criteria

Age40 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Male and female patients aged 40 years or more
  • Patients at risk of venous thromboembolic events being hospitalized for acute medical conditions as follows:
  • Heart failure, New York Heart Association (NYHA) class III or IV
  • Active cancer
  • Acute ischemic stroke
  • Acute infectious and inflammatory diseases, including acute rheumatic diseases
  • Acute respiratory insufficiency
  • Additional risk factor for VTE, including reduced mobility

You may not qualify if:

  • Conditions that contraindicate the use of antithrombotic therapy with the Low Molecular-Weight Heparin (LMWH) enoxaparin
  • Conditions that may increase the risk of bleeding, including intracranial hemorrhage
  • Required drugs or procedures which may interfere with the study treatment
  • Concomitant conditions or diseases which may increase the risk of study subjects or interfere with the study outcome
  • General conditions in which subjects are not suitable to participate in the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (676)

Unknown Facility

Birmingham, Alabama, 35209, United States

Location

Unknown Facility

Birmingham, Alabama, 35235, United States

Location

Unknown Facility

Dothan, Alabama, 36301, United States

Location

Office of Dr. John Simmons, MD

Geneva, Alabama, 36340, United States

Location

Unknown Facility

Mobile, Alabama, 36608, United States

Location

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Montgomery, Alabama, 36111, United States

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Tuscaloosa, Alabama, 35401, United States

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Tuscaloosa, Alabama, 35406, United States

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Little Rock, Arkansas, 72205, United States

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Chula Vista, California, 91911, United States

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Duarte, California, 91010, United States

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Encinitas, California, 92024, United States

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Fountain Valley, California, 92708, United States

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Fullerton, California, 92835, United States

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Glendale, California, 91206, United States

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Oceanside, California, 92056, United States

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Pasadena, California, 91105, United States

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Redlands, California, 92373, United States

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Sacramento, California, 95817, United States

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San Diego, California, 92120, United States

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Santa Barbara, California, 93102, United States

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Torrance, California, 90502-2004, United States

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Denver, Colorado, 80204, United States

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Pueblo, Colorado, 81003, United States

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Wheat Ridge, Colorado, 80033-6017, United States

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Farmington, Connecticut, 06030, United States

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Newark, Delaware, 19718, United States

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Washington D.C., District of Columbia, 20037, United States

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Aventura, Florida, 33180, United States

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Boyton Beach, Florida, 33472, United States

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Clearwater, Florida, 33756, United States

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Delray Beach, Florida, 33445, United States

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Fort Lauderdale, Florida, 33334, United States

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Hollywood, Florida, 33021, United States

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Jupiter, Florida, 33458, United States

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Miami, Florida, 33136, United States

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Miami, Florida, 33173-3259, United States

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Miami Springs, Florida, 33166, United States

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Pembroke Pines, Florida, 33024, United States

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Port Charlotte, Florida, 33952, United States

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Sarasota, Florida, 34232, United States

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Vero Beach, Florida, 32960, United States

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Atlanta, Georgia, 30342, United States

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Decatur, Georgia, 30030, United States

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Fort Gordon, Georgia, 30905, United States

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Savannah, Georgia, 31405, United States

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Idaho Falls, Idaho, 83404, United States

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Chicago, Illinois, 60611, United States

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Springfield, Illinois, 62702, United States

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Anderson, Indiana, 46011, United States

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Noblesville, Indiana, 46060, United States

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Des Moines, Iowa, 50314-2611, United States

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Olathe, Kansas, 66061, United States

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Lafayette, Louisiana, 70503, United States

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New Orleans, Louisiana, 70121, United States

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Shreveport, Louisiana, 71130-4228, United States

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Biddeford, Maine, 04005, United States

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Rockport, Maine, 04856, United States

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Baltimore, Maryland, 21215, United States

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Baltimore, Maryland, 21237, United States

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Framingham, Massachusetts, 01702, United States

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Ann Arbor, Michigan, 48106, United States

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Detroit, Michigan, 48201, United States

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Detroit, Michigan, 48202, United States

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Grand Rapids, Michigan, 49525, United States

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Lansing, Michigan, 48910, United States

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Petoskey, Michigan, 49770-2297, United States

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Pontiac, Michigan, 48341, United States

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Saint Clair Shores, Michigan, 48081, United States

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Minneapolis, Minnesota, 55417, United States

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Kansas City, Missouri, 64128, United States

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St Louis, Missouri, 63110, United States

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St Louis, Missouri, 63141, United States

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Anaconda, Montana, 59711-2718, United States

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Great Falls, Montana, 59405, United States

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Omaha, Nebraska, 68131, United States

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Hackensack, New Jersey, 07601-1991, United States

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New Brunswick, New Jersey, 08901, United States

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Somerville, New Jersey, 08876-2598, United States

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Summit, New Jersey, 07901, United States

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Teaneck, New Jersey, 07666, United States

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Brooklyn, New York, 11215, United States

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Buffalo, New York, 14215-3021, United States

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Jamaica, New York, 11418, United States

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New Hyde Park, New York, 11040-1496, United States

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New York, New York, 10011, United States

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New York, New York, 10065, United States

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Stony Brook, New York, 11794, United States

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Valhalla, New York, 10595, United States

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Durham, North Carolina, 27710, United States

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Elizabeth City, North Carolina, 27909, United States

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Greensboro, North Carolina, 27403, United States

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Fargo, North Dakota, 58122, United States

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Canton, Ohio, 44718, United States

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Columbus, Ohio, 43215, United States

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Maumee, Ohio, 43537-1899, United States

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Toledo, Ohio, 43606, United States

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Bethlehem, Pennsylvania, 18015, United States

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Camp Hill, Pennsylvania, 17011, United States

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Danville, Pennsylvania, 17822, United States

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Philadelphia, Pennsylvania, 19107, United States

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Philadelphia, Pennsylvania, 19124, United States

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Scranton, Pennsylvania, 18510, United States

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Wilkes-Barre, Pennsylvania, 18711-3752, United States

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Charleston, South Carolina, 29425, United States

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Memphis, Tennessee, 38104, United States

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Nashville, Tennessee, 37232-2650, United States

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Corsicana, Texas, 75110, United States

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Dallas, Texas, 75216-7167, United States

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Edinburg, Texas, 78539, United States

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Houston, Texas, 77024, United States

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Houston, Texas, 77030-4009, United States

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Houston, Texas, 77030, United States

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McAllen, Texas, 78503, United States

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San Antonio, Texas, 78218, United States

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Ogden, Utah, 84403, United States

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Richmond, Virginia, 23249, United States

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Richmond, Virginia, 23298, United States

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Everett, Washington, 98201, United States

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Tacoma, Washington, 98405, United States

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Clarksburg, West Virginia, 26301, United States

Location

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Avellaneda, Buenos Aires, B1870CID, Argentina

Location

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San Miguel, Buenos Aires, 1663, Argentina

Location

Hospital de Agudos "Dr. Carlos Bocalandro"

Tres de Febrero, Buenos Aires, 1657, Argentina

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Buenos Aires, Ciudad Auton. de Buenos Aires, 1221, Argentina

Location

Hospital Británico

Buenos Aires, Ciudad Auton. de Buenos Aires, 1280, Argentina

Location

Sanatorio Mitre

Buenos Aires, Ciudad Auton. de Buenos Aires, C1039AAO, Argentina

Location

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Buenos Aires, Ciudad Auton. de Buenos Aires, C1431FWO, Argentina

Location

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Vicente López, 1638, Argentina

Location

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Garran, Australian Capital Territory, 2605, Australia

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Kogarah, New South Wales, 2217, Australia

Location

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Lismore, New South Wales, 2480, Australia

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Sydney, New South Wales, 2229, Australia

Location

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Auchenflower, Queensland, 4066, Australia

Location

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Brisbane, Queensland, 4066, Australia

Location

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Brisbane, Queensland, 4101, Australia

Location

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Redcliffe, Queensland, 4020, Australia

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Southport, Queensland, 4215, Australia

Location

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Woollongabba, Queensland, 4102, Australia

Location

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Adelaide, South Australia, 5042, Australia

Location

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Launceston, Tasmania, 7250, Australia

Location

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Box Hill, Victoria, 3128, Australia

Location

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Clayton, Victoria, 3168, Australia

Location

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Melbourne, Victoria, 3135, Australia

Location

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Melbourne, Victoria, 3144, Australia

Location

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Perth, Western Australia, 6000, Australia

Location

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Kittsee, Burgenland, 2421, Austria

Location

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Oberpullendorf, Burgenland, 7350, Austria

Location

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Wolfsberg, Carinthia, 9400, Austria

Location

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Gratwein, Styria, 8113, Austria

Location

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Graz, Styria, 8036, Austria

Location

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Hartberg, Styria, 8230, Austria

Location

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Leoben, Styria, 8700, Austria

Location

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Zams, Tyrol, 6511, Austria

Location

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Linz, Upper Austria, 4020, Austria

Location

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Vienna, Vienna, 1030, Austria

Location

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Vienna, Vienna, 1100, Austria

Location

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Innsbruck, 6020, Austria

Location

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Linz, 4020, Austria

Location

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Mürzzuschlag, 8680, Austria

Location

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Sankt Pölten, 3100, Austria

Location

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Vienna, 1100, Austria

Location

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Vienna, 1140, Austria

Location

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Aalst, 9300, Belgium

Location

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Bruges, 8000, Belgium

Location

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Bruxelles - Brussel, 1000, Belgium

Location

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Dendermonde, 9200, Belgium

Location

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Hasselt, 3500, Belgium

Location

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Huy, 4500, Belgium

Location

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Ieper, 8900, Belgium

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Leuven, 3000, Belgium

Location

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Malmedy, 4960, Belgium

Location

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Mol, 2400, Belgium

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Montigny S/sambre, 6061, Belgium

Location

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Mortsel, 2640, Belgium

Location

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Roeselare, 8800, Belgium

Location

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Sint-Niklaas, 9100, Belgium

Location

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Tubize, 1480, Belgium

Location

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Turnhout, 2300, Belgium

Location

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Curitiba, Paraná, 80050-350, Brazil

Location

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Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

Location

Unknown Facility

Campinas, São Paulo, 130839 970, Brazil

Location

Unknown Facility

Santo André, São Paulo, 09190-610, Brazil

Location

Unknown Facility

São Paulo, São Paulo, 01323-001, Brazil

Location

Unknown Facility

São Paulo, São Paulo, 04039 002, Brazil

Location

Unknown Facility

São Paulo, São Paulo, 05403-900, Brazil

Location

Unknown Facility

São Paulo, São Paulo, 05443000, Brazil

Location

Unknown Facility

Pleven, 5800, Bulgaria

Location

Unknown Facility

Rousse, 7002, Bulgaria

Location

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Sofia, 1233, Bulgaria

Location

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Sofia, 1606, Bulgaria

Location

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Stara Zagora, 6000, Bulgaria

Location

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Varna, 9010, Bulgaria

Location

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Veliko Tarnovo, 5000, Bulgaria

Location

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Calgary, Alberta, T2N 2T9, Canada

Location

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Edmonton, Alberta, T5H 3V9, Canada

Location

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Edmonton, Alberta, T6G 2B7, Canada

Location

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Edmonton, Alberta, T6L 5X8, Canada

Location

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Vancouver, British Columbia, V5Z 1M9, Canada

Location

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Saint John, New Brunswick, E2L 4L2, Canada

Location

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Cobourg, Ontario, K9A 5W6, Canada

Location

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Ottawa, Ontario, K1Y 4E9, Canada

Location

Unknown Facility

Scarborough Village, Ontario, M1P 2V5, Canada

Location

Unknown Facility

Toronto, Ontario, M5T 2S8, Canada

Location

Hotel Dieu-Grace Hospital

Windsor, Ontario, N9A 1E1, Canada

Location

Unknown Facility

Greenfield Park, Quebec, J4V 2H1, Canada

Location

CHUM - Hopital Notre-Dame

Montreal, Quebec, H2L 4M1, Canada

Location

Unknown Facility

Montreal, Quebec, H2L 4M1, Canada

Location

Unknown Facility

Montreal, Quebec, H2W 1T8, Canada

Location

Unknown Facility

Montreal, Quebec, H3T 1M5, Canada

Location

Unknown Facility

Québec, Quebec, G1J 1Z4, Canada

Location

Unknown Facility

Québec, Quebec, G1V 4G5, Canada

Location

Unknown Facility

Ste-Foy, Quebec, G1V 4G5, Canada

Location

Unknown Facility

Santiago, 760 0448, Chile

Location

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Santiago, Chile

Location

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Viña del Mar, Chile

Location

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Guangzhou, Guangdong, 510120, China

Location

Unknown Facility

Guangzhou, Guangdong, 510405, China

Location

Unknown Facility

Guangzhou, Guangdong, China

Location

Unknown Facility

Changsha, Hunan, 410013, China

Location

Unknown Facility

Nanjing, Jiangsu, 210008, China

Location

Unknown Facility

Nanjing, Jiangsu, China

Location

Unknown Facility

Changchun, Jilin, China

Location

Unknown Facility

Dalian, Liaoning, 116027, China

Location

Unknown Facility

Shenyang, Liaoning, 110001, China

Location

Unknown Facility

Shenyang, Liaoning, 110004, China

Location

Unknown Facility

Shenyang, Liaoning, 110015, China

Location

The 1st Affiliated Hosp of the 4th Military Med Uni

Xi'an, Shaanxi, 710032, China

Location

1st Affiliated Hosp., Med College Xi'an Jiaotong Univ.

Xi'an, Shaanxi, 710061, China

Location

Unknown Facility

Chengdu, Sichuan, 610041, China

Location

Unknown Facility

Beijing, 100005, China

Location

Unknown Facility

Beijing, 100020, China

Location

Unknown Facility

Beijing, 100029, China

Location

Unknown Facility

Beijing, 100034, China

Location

Unknown Facility

Beijing, 100037, China

Location

Unknown Facility

Beijing, 100044, China

Location

Beijing Friendship Hosp.

Beijing, 100050, China

Location

Unknown Facility

Beijing, 100050, China

Location

Unknown Facility

Beijing, 100053, China

Location

Unknown Facility

Beijing, 100088, China

Location

Unknown Facility

Beijing, 100853, China

Location

Unknown Facility

Chongqing, 400038, China

Location

Unknown Facility

Chongqing, 400042, China

Location

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Shanghai, 200003, China

Location

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Shanghai, 200025, China

Location

Unknown Facility

Shanghai, 200127, China

Location

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Shanghai, 200233, China

Location

Unknown Facility

Shanghai, China

Location

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Medellín, Antioquia, Colombia

Location

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Bogotá, Bogota D.C., Colombia

Location

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Cali, Valle del Cauca Department, Colombia

Location

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Bogotá, Colombia

Location

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Cali, Colombia

Location

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Medellín, Colombia

Location

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Osijek, 310 00, Croatia

Location

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Rijeka, 51000, Croatia

Location

Unknown Facility

Zadar, 23000, Croatia

Location

Unknown Facility

Zagreb, 10000, Croatia

Location

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Zagreb, 1000, Croatia

Location

Unknown Facility

Brno, 656 91, Czechia

Location

Unknown Facility

Kutná Hora, 284 30, Czechia

Location

Unknown Facility

Nové Město na Moravě, 592 31, Czechia

Location

Unknown Facility

Olomouc, 775 20, Czechia

Location

Unknown Facility

Pilsen, 305 99, Czechia

Location

Unknown Facility

Prague, 128 08, Czechia

Location

Unknown Facility

Prague, 128 21, Czechia

Location

Unknown Facility

Prague, 12808, Czechia

Location

Unknown Facility

Říčany, 251 49, Czechia

Location

Unknown Facility

Znojmo, 669 02, Czechia

Location

Unknown Facility

Esbjerg, 6700, Denmark

Location

Unknown Facility

Frederiksberg C, 2000, Denmark

Location

Unknown Facility

Kolding, 6000, Denmark

Location

Unknown Facility

København NV, 2400, Denmark

Location

Unknown Facility

København S, 2300, Denmark

Location

Unknown Facility

Roskilde, 4000, Denmark

Location

Unknown Facility

Tallinn, 10138, Estonia

Location

Unknown Facility

Tallinn, 13419, Estonia

Location

Unknown Facility

Tallinn, EE-10617, Estonia

Location

Unknown Facility

Tartu, EE-51014, Estonia

Location

Unknown Facility

Hämeenlinna, 13530, Finland

Location

Unknown Facility

Helsinki, 00290, Finland

Location

Unknown Facility

Jyväskylä, 40620, Finland

Location

Unknown Facility

Lahti, 15850, Finland

Location

Unknown Facility

Lappeenranta, 53130, Finland

Location

Unknown Facility

Raisio, 21200, Finland

Location

Unknown Facility

Turku, 20520, Finland

Location

Unknown Facility

Turku, 20700, Finland

Location

Unknown Facility

Arras, 62000, France

Location

Unknown Facility

Besançon, 25000, France

Location

Unknown Facility

Brest, 29609, France

Location

Unknown Facility

Castelnau-le-Lez, 34170, France

Location

Unknown Facility

Clermont-Ferrand, 63000, France

Location

Unknown Facility

Colombes, 92701, France

Location

Unknown Facility

Dijon, 21000, France

Location

Unknown Facility

Lille, 59037, France

Location

Unknown Facility

Lille, 59307, France

Location

Unknown Facility

Limoges, 87042, France

Location

Unknown Facility

Lomme, 59160, France

Location

Unknown Facility

Lyon, 69003, France

Location

Unknown Facility

Montpellier, 34295, France

Location

Unknown Facility

Nice, 06280, France

Location

Unknown Facility

Nîmes, 30029, France

Location

Unknown Facility

Paris, 75004, France

Location

Unknown Facility

Paris, 75010, France

Location

Unknown Facility

Paris, 75475, France

Location

Unknown Facility

Paris, 75877, France

Location

Unknown Facility

Pierre-Bénite, 69495, France

Location

Unknown Facility

Reims, 51092, France

Location

Unknown Facility

Roubaix, 59100, France

Location

Unknown Facility

Saint-Etienne, 42000, France

Location

Unknown Facility

Saint-Herblain, 44805, France

Location

Unknown Facility

Strasbourg, 67091, France

Location

Unknown Facility

Toulouse, 31403, France

Location

Unknown Facility

Tourcoing, 59208, France

Location

Unknown Facility

Vandœuvre-lès-Nancy, 54511, France

Location

Unknown Facility

Bad Mergentheim, Baden-Wurttemberg, 97980, Germany

Location

Unknown Facility

Esslingen am Neckar, Baden-Wurttemberg, 73730, Germany

Location

Unknown Facility

Heidelberg, Baden-Wurttemberg, 69120, Germany

Location

Unknown Facility

Karlsbad, Baden-Wurttemberg, 76307, Germany

Location

Unknown Facility

Weiden, Bavaria, 92637, Germany

Location

Unknown Facility

Beeskow, Brandenburg, 15848, Germany

Location

Unknown Facility

Frankfurt (Oder), Brandenburg, 15236, Germany

Location

Unknown Facility

Bremen, City state Bremen, 28177, Germany

Location

Unknown Facility

Cologne, North Rhine-Westphalia, 50935, Germany

Location

Unknown Facility

Cologne, North Rhine-Westphalia, 51067, Germany

Location

Unknown Facility

Cologne, North Rhine-Westphalia, 51109, Germany

Location

Unknown Facility

Dortmund, North Rhine-Westphalia, 44137, Germany

Location

Unknown Facility

Jülich, North Rhine-Westphalia, 52428, Germany

Location

Unknown Facility

Leverkusen, North Rhine-Westphalia, 51375, Germany

Location

Unknown Facility

Mönchengladbach, North Rhine-Westphalia, 41063, Germany

Location

Unknown Facility

Neuss, North Rhine-Westphalia, 41464, Germany

Location

Unknown Facility

Oberhausen, North Rhine-Westphalia, 46045, Germany

Location

Unknown Facility

Paderborn, North Rhine-Westphalia, 33098, Germany

Location

Unknown Facility

Soest, North Rhine-Westphalia, 59494, Germany

Location

Unknown Facility

Stolberg, North Rhine-Westphalia, 52222, Germany

Location

Unknown Facility

Troisdorf, North Rhine-Westphalia, 53844, Germany

Location

Unknown Facility

Viersen, North Rhine-Westphalia, 41749, Germany

Location

Unknown Facility

Wuppertal, North Rhine-Westphalia, 42109, Germany

Location

Unknown Facility

Mainz, Rhineland-Palatinate, 55131, Germany

Location

Unknown Facility

Neuwied, Rhineland-Palatinate, 56564, Germany

Location

Unknown Facility

Dresden, Saxony, 01067, Germany

Location

Unknown Facility

Dresden, Saxony, 01307, Germany

Location

Unknown Facility

Leipzig, Saxony, 04289, Germany

Location

Unknown Facility

Pirna, Saxony, 01796, Germany

Location

Unknown Facility

Halle, Saxony-Anhalt, 06112, Germany

Location

Unknown Facility

Berlin, State of Berlin, 10787, Germany

Location

Unknown Facility

Elefsina, Attica, 19018, Greece

Location

Unknown Facility

Kifisia / Athens, Attica, 14561, Greece

Location

Unknown Facility

Abelokipi - Athens, 115 26, Greece

Location

Unknown Facility

Athens, 106 76, Greece

Location

Unknown Facility

Athens, 115 26, Greece

Location

Unknown Facility

Athens, 156 69, Greece

Location

Unknown Facility

Nea Ionia, 14233, Greece

Location

Unknown Facility

Piraeus, 18536, Greece

Location

Unknown Facility

Rio / Patras, 265 04, Greece

Location

Unknown Facility

Shatin, N.t., Hong Kong

Location

Unknown Facility

Shatin, Hong Kong

Location

Unknown Facility

Baja, 6500, Hungary

Location

Unknown Facility

Balassagyarmat, 2660, Hungary

Location

Unknown Facility

Budapest, 1076, Hungary

Location

Unknown Facility

Budapest, 1134, Hungary

Location

Unknown Facility

Budapest, 1145, Hungary

Location

Unknown Facility

Debrecen, 4012, Hungary

Location

Unknown Facility

Győr, 9024, Hungary

Location

Unknown Facility

Hódmezővásárhely, 6800, Hungary

Location

Unknown Facility

Kecskemét, 6000, Hungary

Location

Unknown Facility

Székesfehérvár, 8000, Hungary

Location

Unknown Facility

Tatabánya, 2800, Hungary

Location

Unknown Facility

Zalaegerszeg-Pozva, H-8900, Hungary

Location

Unknown Facility

Ahmedabad, Gujar?t, 380 054, India

Location

Unknown Facility

Bangalore, Karn?taka, 560052, India

Location

Unknown Facility

Bangalore, Karn?taka, 560099, India

Location

Unknown Facility

Calicut, Kerala, 673 004, India

Location

Unknown Facility

Thiruvananthapuram, Kerala, 695002, India

Location

Unknown Facility

Pune, Maharashtra, 411001, India

Location

Unknown Facility

Pune, Maharashtra, 411011, India

Location

Unknown Facility

Ludhiana, Punjab, 141001, India

Location

Unknown Facility

Chennai, Tamil N?du, 600081, India

Location

Unknown Facility

Coimbatore, Tamil N?du, 641 004, India

Location

Unknown Facility

Kolkata, West Bengal, 700 099, India

Location

Unknown Facility

Hyderabad, 500034, India

Location

Unknown Facility

Hyderabad, 500082, India

Location

Unknown Facility

Hyderabad, 600 038, India

Location

Unknown Facility

Mumbai, 400022, India

Location

Unknown Facility

Noida, India

Location

Unknown Facility

Jakarta, 10430, Indonesia

Location

Unknown Facility

Jakarta, 11420, Indonesia

Location

Unknown Facility

Surabaya, 60286, Indonesia

Location

Unknown Facility

Afula, 1834111, Israel

Location

Unknown Facility

Ashkelon, 7830604, Israel

Location

Unknown Facility

Haifa, 31048, Israel

Location

Unknown Facility

Haifa, 3109601, Israel

Location

Unknown Facility

Holon, 58100, Israel

Location

Unknown Facility

Kfar Saba, 4428164, Israel

Location

Unknown Facility

Rehovot, 7610001, Israel

Location

Unknown Facility

Safed, 1311001, Israel

Location

Unknown Facility

Tel Aviv, 64239, Israel

Location

Unknown Facility

Acquaviva delle Fonti, Bari, 70021, Italy

Location

Unknown Facility

Napoli, Campania, 80123, Italy

Location

Unknown Facility

Modena, Emilia-Romagna, 41100, Italy

Location

Unknown Facility

Parma, Emilia-Romagna, 43100, Italy

Location

Unknown Facility

Piacenza, Emilia-Romagna, 29121, Italy

Location

Unknown Facility

Reggio Emilia, Emilia-Romagna, 42123, Italy

Location

Unknown Facility

Rome, Lazio, 00161, Italy

Location

Unknown Facility

Rome, Lazio, 00168, Italy

Location

Unknown Facility

Genoa, Liguria, 16128, Italy

Location

Unknown Facility

Milan, Lombardy, 20089, Italy

Location

Unknown Facility

Milan, Lombardy, 20133, Italy

Location

Unknown Facility

Milan, Lombardy, 20162, Italy

Location

Unknown Facility

Varese, Lombardy, 21100, Italy

Location

Unknown Facility

Campobasso, Molise, 86100, Italy

Location

Unknown Facility

Fidenza, Parma, 43036, Italy

Location

Unknown Facility

Catania, Sicily, 95124, Italy

Location

Unknown Facility

Palermo, Sicily, 90127, Italy

Location

Unknown Facility

Terni, Trentino-Alto Adige, 05019, Italy

Location

Unknown Facility

Perugia, Umbria, 06024, Italy

Location

Unknown Facility

Perugia, Umbria, 06156, Italy

Location

Unknown Facility

Domodossola, Verbano-Cusio-Ossola, 28845, Italy

Location

Unknown Facility

Bergamo, 24128, Italy

Location

Unknown Facility

Latina, 04100, Italy

Location

Unknown Facility

Reggio Calabria, 89124, Italy

Location

Unknown Facility

Vicenza, 36100, Italy

Location

Unknown Facility

Ichinomiya, Aichi-ken, 491-8551, Japan

Location

Unknown Facility

Kasugai, Aichi-ken, 487-0013, Japan

Location

Unknown Facility

Ōbu, Aichi-ken, 474-8511, Japan

Location

Unknown Facility

Matsuyama, Ehime, 790-0024, Japan

Location

Unknown Facility

Tōon, Ehime, 791-0281, Japan

Location

Unknown Facility

Fukui-shi, Fukui, 910-8561, Japan

Location

Unknown Facility

Chikushino-shi, Fukuoka, 818-8516, Japan

Location

Unknown Facility

Takasaki, Gunma, 370-0829, Japan

Location

Unknown Facility

Kure, Hiroshima, 737-0023, Japan

Location

Unknown Facility

Hakodate, Hokkaido, 040-8611, Japan

Location

Unknown Facility

Sapporo, Hokkaido, 065-0033, Japan

Location

Unknown Facility

Amagasaki, Hyōgo, 660-8511, Japan

Location

National Hospital Organization Ibaraki Higashi Hospital

Ibaraki, Ibaraki, 319-1113, Japan

Location

Unknown Facility

Kanazawa, Ishikawa-ken, 920-8650, Japan

Location

Unknown Facility

Hanamaki, Iwate, 025-0075, Japan

Location

Unknown Facility

Ebina, Kanagawa, 243-0433, Japan

Location

Unknown Facility

Kamakura, Kanagawa, 247-8533, Japan

Location

Unknown Facility

Yokohama, Kanagawa, 236-0051, Japan

Location

Unknown Facility

Nangoku, Kochi, 783-8509, Japan

Location

Unknown Facility

Kumamoto, Kumamoto, 860-0008, Japan

Location

Unknown Facility

Kyoto, Kyoto, 606-8507, Japan

Location

Unknown Facility

Matsusaka, Mie-ken, 515-8544, Japan

Location

Unknown Facility

Tsu, Mie-ken, 514-1101, Japan

Location

Unknown Facility

Tsu, Mie-ken, 514-8507, Japan

Location

Unknown Facility

Kashiwazaki, Niigata, 945-8585, Japan

Location

Unknown Facility

Tomigusuku, Okinawa, 901-0243, Japan

Location

Unknown Facility

Urasoe, Okinawa, 901-2132, Japan

Location

Unknown Facility

Daitō, Osaka, 574-0074, Japan

Location

Unknown Facility

Yao, Osaka, 581-0011, Japan

Location

Unknown Facility

Kusatsu, Shiga, 525-8585, Japan

Location

Unknown Facility

Hamamatsu, Shizuoka, 432-8580, Japan

Location

Unknown Facility

Meguro-ku, Tokyo, 152-8902, Japan

Location

Unknown Facility

Shinjuku-ku, Tokyo, 162-8655, Japan

Location

Unknown Facility

Shimonoseki, Yamaguchi, 750-0061, Japan

Location

Unknown Facility

Daugavpils, LV-5417, Latvia

Location

Unknown Facility

Liepāja, 3402, Latvia

Location

Unknown Facility

Riga, 1002, Latvia

Location

Unknown Facility

Riga, 1005, Latvia

Location

Unknown Facility

Riga, LV-1001, Latvia

Location

Unknown Facility

Riga, LV-1038, Latvia

Location

Unknown Facility

Valmiera, LV-4201, Latvia

Location

Unknown Facility

Ventspils, LV-3601, Latvia

Location

Unknown Facility

Kaunas, LT-3000, Lithuania

Location

Unknown Facility

Kaunas, LT-3002, Lithuania

Location

Unknown Facility

Kaunas, LT-3026, Lithuania

Location

Unknown Facility

Klaipėda, LT-5800, Lithuania

Location

Unknown Facility

Klaipėda, LT-92231, Lithuania

Location

Unknown Facility

Šiauliai, 76231, Lithuania

Location

Unknown Facility

Utena, LT-28142, Lithuania

Location

Unknown Facility

Vilnius, 04130, Lithuania

Location

Unknown Facility

Vilnius, 10207, Lithuania

Location

Unknown Facility

Vilnius, LT-2001, Lithuania

Location

Unknown Facility

Luxembourg, 1210, Luxembourg

Location

Unknown Facility

Luxembourg-Kirchberg, 2540, Luxembourg

Location

Unknown Facility

Niedercorn, 4602, Luxembourg

Location

Unknown Facility

Kuala Lumpur, 59100, Malaysia

Location

Unknown Facility

Negeri Sembilan,, 70300, Malaysia

Location

Unknown Facility

Sarawak, 93400, Malaysia

Location

Unknown Facility

Aguascalientes, Aguascalientes, 20234, Mexico

Location

Unknown Facility

Tuxtla Gutiérrez, Chiapas, 29000, Mexico

Location

Unknown Facility

Chihuahua City, Chihuahua, 31350, Mexico

Location

Unknown Facility

Torreón, Coahuila, 27250, Mexico

Location

Unknown Facility

Guadalajara, Jalisco, 44280, Mexico

Location

Unknown Facility

Mexico City, Mexico City, 11340, Mexico

Location

Unknown Facility

Mexico City, Mexico City, 15900, Mexico

Location

Unknown Facility

Mexico D. F., Mexico City, 06760, Mexico

Location

Unknown Facility

México, D.F, Mexico City, 07460, Mexico

Location

Unknown Facility

México, D.F., Mexico City, 06729, Mexico

Location

Unknown Facility

México, D.F., Mexico City, 07760, Mexico

Location

Unknown Facility

Morelia, Michoacán, 58270, Mexico

Location

Unknown Facility

Monterrey, Nuevo León, 66480, Mexico

Location

Unknown Facility

Puebla City, Puebla, 72410, Mexico

Location

Unknown Facility

Hermosillo, Sonora, 83000, Mexico

Location

Unknown Facility

Metepec, State of Mexico, 52140, Mexico

Location

Unknown Facility

Mérida, Yucatán, 97001, Mexico

Location

Unknown Facility

Zacatecas City, Zacatecas, 98000, Mexico

Location

Unknown Facility

Amersfoort, 3816 CP, Netherlands

Location

Unknown Facility

Amsterdam, 1061 AE, Netherlands

Location

Unknown Facility

Enschede, 7511 JX, Netherlands

Location

Unknown Facility

Heerlen, 6401 CX, Netherlands

Location

Unknown Facility

Maastricht, 6229 HX, Netherlands

Location

Unknown Facility

Nieuwegein, 3435 CM, Netherlands

Location

Unknown Facility

Rotterdam, 3083 AN, Netherlands

Location

Unknown Facility

Sittard, 6131 BK, Netherlands

Location

Unknown Facility

Utrecht, 3582 KE, Netherlands

Location

Unknown Facility

Auckland, 0622, New Zealand

Location

Unknown Facility

Auckland, 1023, New Zealand

Location

Unknown Facility

Auckland, 2024, New Zealand

Location

Unknown Facility

Christchurch, 8011, New Zealand

Location

Unknown Facility

Fredrikstad, 1603, Norway

Location

Unknown Facility

Gjøvik, 2819, Norway

Location

Unknown Facility

Hamar, 2326, Norway

Location

Unknown Facility

Oslo, 0319, Norway

Location

Unknown Facility

Oslo, 0407, Norway

Location

Unknown Facility

Karachi, 74800, Pakistan

Location

Unknown Facility

Karachi, 75500, Pakistan

Location

Unknown Facility

Lahore, Pakistan

Location

Unknown Facility

Callao, CALLAO 2, Peru

Location

Unknown Facility

Lima, 01, Peru

Location

Unknown Facility

Lima, 31, Peru

Location

Unknown Facility

Lima, LIMA 11, Peru

Location

Unknown Facility

Lima, LIMA 1, Peru

Location

Unknown Facility

Lima Cercado, LIMA 1, Peru

Location

Unknown Facility

Bialystok, 15-276, Poland

Location

Unknown Facility

Bydgoszcz, 85-681, Poland

Location

Unknown Facility

Krakow, 31-066, Poland

Location

Unknown Facility

Krakow, 31-121, Poland

Location

Unknown Facility

Lublin, 20-178, Poland

Location

Unknown Facility

Olsztyn, 10-228, Poland

Location

Unknown Facility

Piotrkow Trybunalski, 97-300, Poland

Location

Unknown Facility

Siedlce, 08-110, Poland

Location

Unknown Facility

Starogard Gdański, 83-200, Poland

Location

Unknown Facility

Szczecin, 70-965, Poland

Location

Unknown Facility

Tarnów, 33-100, Poland

Location

Unknown Facility

Warsaw, 03-401, Poland

Location

Unknown Facility

Warsaw, 04-141, Poland

Location

Unknown Facility

Warsaw, 04-749, Poland

Location

Unknown Facility

Włocławek, 87-800, Poland

Location

Unknown Facility

S. Martinho Do Bispo, Coimbra District, 3041-856, Portugal

Location

Unknown Facility

Lisbon, Lisbon District, 1150-199, Portugal

Location

Unknown Facility

Lisbon, Lisbon District, 1649-035, Portugal

Location

Unknown Facility

Porto, Porto District, 4099-001, Portugal

Location

Unknown Facility

Santarém, Santarém District, 2005, Portugal

Location

Unknown Facility

Amadora, 2720-276, Portugal

Location

Unknown Facility

Cascais, 2750-349, Portugal

Location

Unknown Facility

Coimbra, 3000-075, Portugal

Location

Unknown Facility

Lisbon, 1349-019, Portugal

Location

Unknown Facility

Lisbon, 1849- 017, Portugal

Location

Unknown Facility

Matosinhos Municipality, 4454-509, Portugal

Location

Unknown Facility

Porto, 4200-319, Portugal

Location

Unknown Facility

Viana do Castelo, 4901-585, Portugal

Location

Unknown Facility

Bucharest, 014461, Romania

Location

Unknown Facility

Bucharest, 022328, Romania

Location

Unknown Facility

Bucharest, 041915, Romania

Location

Unknown Facility

Constanța, 900591, Romania

Location

Unknown Facility

Suceava, 720237, Romania

Location

Unknown Facility

Moscow, 103030, Russia

Location

Unknown Facility

Moscow, 115093, Russia

Location

Unknown Facility

Moscow, 115516, Russia

Location

Unknown Facility

Moscow, 117292, Russia

Location

Unknown Facility

Moscow, 119048, Russia

Location

Unknown Facility

Moscow, 119435, Russia

Location

Unknown Facility

Moscow, 125101, Russia

Location

Unknown Facility

Moscow, 125367, Russia

Location

Unknown Facility

Nizhny Novgorod, 603001, Russia

Location

Unknown Facility

Nizhny Novgorod, 603035, Russia

Location

Unknown Facility

Yaroslavl, 150003, Russia

Location

Unknown Facility

Yaroslavl, 150030, Russia

Location

Unknown Facility

Singapore, 119074, Singapore

Location

Unknown Facility

Singapore, 168752, Singapore

Location

Unknown Facility

Singapore, 169608, Singapore

Location

Unknown Facility

Singapore, 308433, Singapore

Location

Changi General Hospital

Singapore, 529889, Singapore

Location

Unknown Facility

Bratislava, 813 69, Slovakia

Location

Unknown Facility

Bratislava, 826 06, Slovakia

Location

Unknown Facility

Lučenec, 984 39, Slovakia

Location

Unknown Facility

Martin, 036 59, Slovakia

Location

Unknown Facility

Žilina, 012 07, Slovakia

Location

Unknown Facility

Golnik, 4204, Slovenia

Location

Unknown Facility

Ljubljana, 1000, Slovenia

Location

Unknown Facility

Novo Mesto, 8000, Slovenia

Location

Unknown Facility

Bloemfontein, Freestate, 9301, South Africa

Location

Unknown Facility

Johannesburg, Gauteng, 2057, South Africa

Location

Unknown Facility

Johannesburg, Gauteng, 2132, South Africa

Location

Unknown Facility

Johannesburg, Gauteng, 2196, South Africa

Location

Unknown Facility

Kempton Park, Gauteng, 1610, South Africa

Location

Unknown Facility

Pretoria, Gauteng, 0084, South Africa

Location

Unknown Facility

Pretoria, Gauteng, 0157, South Africa

Location

Unknown Facility

Pretoria, Gauteng, 0181, South Africa

Location

Unknown Facility

Roodepoort, Gauteng, 1724, South Africa

Location

Unknown Facility

Sandton, Gauteng, South Africa, 2196, South Africa

Location

Unknown Facility

Goodwood, Western Cape, 7460, South Africa

Location

Unknown Facility

Somerset West, Western Cape, 7130, South Africa

Location

Unknown Facility

Stellenbosch, Western Cape, 7505, South Africa

Location

Unknown Facility

Worcester, Western Cape, 6850, South Africa

Location

Unknown Facility

Gyeongi-do, Korea, 463-707, South Korea

Location

Seoul National University Hospital

Seoul, Seoul Teugbyeolsi, 110-744, South Korea

Location

Seoul Metropolitan Boramae Hospital

Seoul, Seoul Teugbyeolsi, 156-707, South Korea

Location

Unknown Facility

Gyeonggi-do, 463-712, South Korea

Location

Unknown Facility

Jeollanam-do, 519-763, South Korea

Location

Unknown Facility

Seoul, 135-710, South Korea

Location

Unknown Facility

Seoul, 138736, South Korea

Location

Unknown Facility

Badalona, Barcelona, 08916, Spain

Location

Unknown Facility

Barcelona, Barcelona, 08023, Spain

Location

Unknown Facility

Barcelona, Barcelona, 08036, Spain

Location

Unknown Facility

Sabadell, Barcelona, 08208, Spain

Location

Unknown Facility

Cuenca, Cuenca, 16002, Spain

Location

Unknown Facility

Cabra, Córdoba, 14940, Spain

Location

Unknown Facility

Córdoba, Córdoba, 14004, Spain

Location

Unknown Facility

Girona, Girona, 17007, Spain

Location

Unknown Facility

Olot, Girona, 17800, Spain

Location

Unknown Facility

Cartagena, Murcia, 30202, Spain

Location

Unknown Facility

Vélez, Málaga, 29700, Spain

Location

Unknown Facility

Vigo, Pontevedra, 36214, Spain

Location

Unknown Facility

Zaragoza, Zaragoza, 50009, Spain

Location

Unknown Facility

Borås, 501 82, Sweden

Location

Unknown Facility

Hässleholm, 281 25, Sweden

Location

Unknown Facility

Karlshamn, 374 80, Sweden

Location

Unknown Facility

Kristianstad, 29185, Sweden

Location

Unknown Facility

Lund, 221 85, Sweden

Location

Unknown Facility

Malmo, 205 02, Sweden

Location

Unknown Facility

Skövde, 541 85, Sweden

Location

Unknown Facility

Stockholm, 171 76, Sweden

Location

Unknown Facility

Stockholm, 182 88, Sweden

Location

Unknown Facility

Sundsvall, 851 86, Sweden

Location

Unknown Facility

Umeå, 90185, Sweden

Location

Unknown Facility

Visby, 62184, Sweden

Location

Unknown Facility

Bruderholz, Basel-Landschaft, 4101, Switzerland

Location

Unknown Facility

Basel, Canton of Basel-City, 4031, Switzerland

Location

Unknown Facility

Liestal, Canton of Basel-City, 4410, Switzerland

Location

Unknown Facility

Bern, Canton of Bern, 3010, Switzerland

Location

Unknown Facility

Langenthal, Canton of Bern, 4901, Switzerland

Location

Unknown Facility

Geneva, Canton of Geneva, 1211, Switzerland

Location

Unknown Facility

Zurich, Canton of Zurich, 8091, Switzerland

Location

Unknown Facility

Baden, 5404, Switzerland

Location

Unknown Facility

Lucerne, 6000, Switzerland

Location

Unknown Facility

Kaohsiung City, 833, Taiwan

Location

Unknown Facility

Tainan, 710, Taiwan

Location

Unknown Facility

Taipei, 10016, Taiwan

Location

Unknown Facility

Taipei, 114, Taiwan

Location

Unknown Facility

Taipei, Taiwan

Location

Unknown Facility

Bangkok, Thailand, 10700, Thailand

Location

Unknown Facility

Bangkok, 10400, Thailand

Location

Unknown Facility

Chiang Mai, 50200, Thailand

Location

Unknown Facility

Istanbul, 34098, Turkey (Türkiye)

Location

Unknown Facility

Istanbul, 34304, Turkey (Türkiye)

Location

Unknown Facility

Izmir, 35100, Turkey (Türkiye)

Location

Unknown Facility

Izmir, 35340, Turkey (Türkiye)

Location

Unknown Facility

Donetsk, 83003, Ukraine

Location

Unknown Facility

Donetsk, 83045, Ukraine

Location

Unknown Facility

Ivano-Frankivsk, 76000, Ukraine

Location

Unknown Facility

Kharkiv, 61037, Ukraine

Location

Unknown Facility

Kharkiv, 61070, Ukraine

Location

Unknown Facility

Kharkiv, 61178, Ukraine

Location

Unknown Facility

Kiev, 02 091, Ukraine

Location

Unknown Facility

Kiev, 03680, Ukraine

Location

Unknown Facility

Kiev, 04112, Ukraine

Location

Unknown Facility

Kyiv, 01105, Ukraine

Location

Unknown Facility

Lviv, 790 34, Ukraine

Location

Unknown Facility

Odesa, 65009, Ukraine

Location

Unknown Facility

Odesa, 65025, Ukraine

Location

Unknown Facility

Simferopol, 95 026, Ukraine

Location

Unknown Facility

Simferopol, 95023, Ukraine

Location

Unknown Facility

Middlesbrough, Cleveland, TS4 3BW, United Kingdom

Location

Unknown Facility

Dumfries, Dumfries and Galloway, DG1 4EP, United Kingdom

Location

Unknown Facility

London, London, N18 1QX, United Kingdom

Location

Unknown Facility

London, London, SE5 9RS, United Kingdom

Location

Unknown Facility

Liverpool, Merseyside, L9 7JU, United Kingdom

Location

Unknown Facility

Sheffield, South Yorkshire, S10 2JF, United Kingdom

Location

Unknown Facility

Glasgow, Stratchclyde, G11 6NT, United Kingdom

Location

Unknown Facility

Newcastle upon Tyne, Tyne and Wear, NE1 4LP, United Kingdom

Location

Unknown Facility

Leeds, West Yorkshire, LS9 7TF, United Kingdom

Location

Unknown Facility

London, W1T 4EU, United Kingdom

Location

Unknown Facility

Nottingham, NG7 2UH, United Kingdom

Location

Related Publications (12)

  • Cohen AT, Spiro TE, Buller HR, Haskell L, Hu D, Hull R, Mebazaa A, Merli G, Schellong S, Spyropoulos A, Tapson V. Extended-duration rivaroxaban thromboprophylaxis in acutely ill medical patients: MAGELLAN study protocol. J Thromb Thrombolysis. 2011 May;31(4):407-16. doi: 10.1007/s11239-011-0549-x.

  • Cohen AT, Spiro TE, Buller HR, Haskell L, Hu D, Hull R, Mebazaa A, Merli G, Schellong S, Spyropoulos AC, Tapson V; MAGELLAN Investigators. Rivaroxaban for thromboprophylaxis in acutely ill medical patients. N Engl J Med. 2013 Feb 7;368(6):513-23. doi: 10.1056/NEJMoa1111096.

  • Sharma A, Chatterjee S, Lichstein E, Mukherjee D. Extended thromboprophylaxis for medically ill patients with decreased mobility: does it improve outcomes? J Thromb Haemost. 2012 Oct;10(10):2053-60. doi: 10.1111/j.1538-7836.2012.04874.x.

  • Mebazaa A, Spiro TE, Buller HR, Haskell L, Hu D, Hull R, Merli G, Schellong SW, Spyropoulos AC, Tapson VF, De Sanctis Y, Cohen AT. Predicting the risk of venous thromboembolism in patients hospitalized with heart failure. Circulation. 2014 Jul 29;130(5):410-8. doi: 10.1161/CIRCULATIONAHA.113.003126. Epub 2014 Jun 26.

  • Cohen AT, Spiro TE, Spyropoulos AC, Desanctis YH, Homering M, Buller HR, Haskell L, Hu D, Hull R, Mebazaa A, Merli G, Schellong S, Tapson VF, Burton P; MAGELLAN Study Group. D-dimer as a predictor of venous thromboembolism in acutely ill, hospitalized patients: a subanalysis of the randomized controlled MAGELLAN trial. J Thromb Haemost. 2014 Apr;12(4):479-87. doi: 10.1111/jth.12515.

  • Spyropoulos AC, Raskob GE, Cohen AT, Ageno W, Weitz JI, Spiro TE, Lu W, Lipardi C, Albers GW, Elliott CG, Halperin JL, Hiatt WR, Maynard G, Steg PG, Sugarmann C, Barnathan ES. Association of Bleeding Severity With Mortality in Extended Thromboprophylaxis of Medically Ill Patients in the MAGELLAN and MARINER Trials. Circulation. 2022 May 10;145(19):1471-1479. doi: 10.1161/CIRCULATIONAHA.121.057847. Epub 2022 Apr 7.

  • Raskob GE, Spyropoulos AC, Spiro TE, Lu W, Yuan Z, Levitan B, Suh E, Barnathan ES. Benefit-Risk of Rivaroxaban for Extended Thromboprophylaxis After Hospitalization for Medical Illness: Pooled Analysis From MAGELLAN and MARINER. J Am Heart Assoc. 2021 Nov 16;10(22):e021579. doi: 10.1161/JAHA.121.021579. Epub 2021 Nov 10.

  • Raskob GE, Spyropoulos AC, Cohen AT, Weitz JI, Ageno W, De Sanctis Y, Lu W, Xu J, Albanese J, Sugarmann C, Weber T, Lipardi C, Spiro TE, Barnathan ES. Association Between Asymptomatic Proximal Deep Vein Thrombosis and Mortality in Acutely Ill Medical Patients. J Am Heart Assoc. 2021 Feb;10(5):e019459. doi: 10.1161/JAHA.120.019459. Epub 2021 Feb 15.

  • Jamil A, Jamil U, Singh K, Khan F, Chi G. Extended Thromboprophylaxis With Betrixaban or Rivaroxaban for Acutely Ill Hospitalized Medical Patients: Meta-Analysis of Prespecified Subgroups. Crit Pathw Cardiol. 2021 Mar 1;20(1):16-24. doi: 10.1097/HPC.0000000000000232.

  • Weitz JI, Raskob GE, Spyropoulos AC, Spiro TE, De Sanctis Y, Xu J, Lu W, Suh E, Argenti D, Yang H, Albanese J, Lipardi C, Barnathan ES. Thromboprophylaxis with Rivaroxaban in Acutely Ill Medical Patients with Renal Impairment: Insights from the MAGELLAN and MARINER Trials. Thromb Haemost. 2020 Mar;120(3):515-524. doi: 10.1055/s-0039-1701009. Epub 2020 Jan 23.

  • Chi G, Goldhaber SZ, Kittelson JM, Turpie AGG, Hernandez AF, Hull RD, Gold A, Curnutte JT, Cohen AT, Harrington RA, Gibson CM. Effect of extended-duration thromboprophylaxis on venous thromboembolism and major bleeding among acutely ill hospitalized medical patients: a bivariate analysis. J Thromb Haemost. 2017 Oct;15(10):1913-1922. doi: 10.1111/jth.13783. Epub 2017 Sep 4.

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Related Links

MeSH Terms

Conditions

Venous ThromboembolismVenous ThrombosisPulmonary Embolism

Interventions

RivaroxabanEnoxaparin

Condition Hierarchy (Ancestors)

ThromboembolismEmbolism and ThrombosisVascular DiseasesCardiovascular DiseasesThrombosisLung DiseasesRespiratory Tract DiseasesEmbolism

Intervention Hierarchy (Ancestors)

ThiophenesSulfur CompoundsOrganic ChemicalsMorpholinesOxazinesHeterocyclic Compounds, 1-RingHeterocyclic CompoundsHeparin, Low-Molecular-WeightHeparinGlycosaminoglycansPolysaccharidesCarbohydrates

Limitations and Caveats

A heterogeneous population (with different acute medical illnesses and severity of illness) was included in the trial. VTE risk in acute medical illnesses is moderate \[with no thromboprophylaxis\] .

Results Point of Contact

Title
Therapeutic Area Head
Organization
BAYER

Study Officials

  • Bayer Study Director

    Bayer

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
GT60
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 11, 2007

First Posted

December 12, 2007

Study Start

December 1, 2007

Primary Completion

August 1, 2010

Study Completion

November 1, 2010

Last Updated

September 15, 2016

Results First Posted

June 27, 2012

Record last verified: 2016-08

Locations