Left Atrial Volume and Function Evaluation in Patients With Obstructive Sleep Apnea

NCT00570115 | Completed

• 1 other identifier: ecoera-001
• Study Type: observational
• Target: 106
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine whether patients with obstructive sleep apnea have any changes in left atrial morphology and function evaluated by echocardiography three dimensional

Conditions

Sleep Apnea Syndromes

Keywords

Sleep Apnea Syndromes diastolic disfunction left atrium

Outcome Measures

Primary Outcomes (1)

• Left Atrial enlargement

  1 day

Study Arms (1)

A

The subjects for this group are matched for age, gender, body mass index. The presence of obstructive sleep apnea will divide the cohort in 02 subgroups: non-Obstructive Sleep Apnea and Obstructive Sleep Apnea

Eligibility Criteria

• Age: 30 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The investigators recruited 56 recently diagnosed OSA patients, confirmed by full polysomnography (PSG), referred to Sleep Laboratory of Psychobiology Department of Federal University of Sao Paulo, Brazil, according to the following inclusion criteria: both genders aging from 29 to 70 years old, with apnea-hypopnea index (AHI) \>5 events/hour of sleep. Control group comprised 50 healthy community subjects without OSA confirmed by full PSG, matched by age, gender, and BMI.

You may qualify if:

• Age from 30 to 70
• Apnea-hypopnea index \> 5 by polysomnography

You may not qualify if:

• Any cardiac disease
• Poor imaging quality by mean of echocardiography
• non-sinusal Rhythm

Sponsors & Collaborators

• Associação Fundo de Incentivo à Pesquisa: lead

Study Sites (1)

Instituto do Sono/Federal University of Sao Paulo

São Paulo, São Paulo, 04020060, Brazil

Location

Related Publications (1)

• Anwar AM, Soliman OI, Geleijnse ML, Nemes A, Vletter WB, ten Cate FJ. Assessment of left atrial volume and function by real-time three-dimensional echocardiography. Int J Cardiol. 2008 Jan 11;123(2):155-61. doi: 10.1016/j.ijcard.2006.12.017. Epub 2007 Apr 17.

  PMID: 17442422 BACKGROUND

MeSH Terms

Conditions

Sleep Apnea Syndromes

Condition Hierarchy (Ancestors)

Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases

Study Officials

• Sergio Tufik, PhD,MD.

  Federal University of São Paulo

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: December 7, 2007
• First Posted: December 10, 2007
• Study Start: June 1, 2007
• Study Completion: November 1, 2007
• Last Updated: May 8, 2012

Record last verified: 2007-12

Locations

BR (1)