Clinical Characteristics of Patients With Sleep Apnea in Korea

NCT04186078 | Recruiting

• 1 other identifier: 19071511050
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

Sleep-disordered breathing including obstructive sleep apnea (OSA) is an extremely common medical disorder associated with important morbidity. The purpose of this study is to understand the clinical features and course of patients with sleep apnea in Korea. Participants who are suspected of sleep apnea due to symptoms such as snoring, witnessed apneas, waking up with a choking sensation, excessive sleepiness, non-restorative sleep, difficulty initiating or maintaining sleep, fatigue or tiredness, and morning headache will be prospectively recruited at the outpatient clinic of Seoul National University Hospital. After polysomnography (PSG) or respiratory polygraphy, patients with sleep apnea including OSA and central sleep apnea (CSA) will be followed regularly. Participants not having sleep apnea (apnea-hypopnea index \< 5/hour) will only have a baseline visit. For only participants with the informed consent of donating blood, their blood samples will be collected and stored in the Seoul National University Hospital-Human Biobank (SNUH-HUB).

Conditions

Sleep Apnea Syndromes

Outcome Measures

Primary Outcomes (1)

• The number of participants with adherence to positive airway pressure (PAP) therapy

  PAP adherence is defined as the use of PAP therapy for ≥4 h/night on ≥70% of nights

  Median follow up of 2 years

Secondary Outcomes (2)

• The number of deaths

  Median follow up of 15 years

• The cause of death

  Median follow up of 15 years

Other Outcomes (1)

• Change of FEV1 and FVC in patients with OSA

  Median follow up of 5 years

Study Arms (3)

obstructive sleep apnea (OSA)

5 or more predominantly obstructive respiratory events \[obstructive and mixed apneas, hypopneas or respiratory effort-related arousals (RERAs)\] per hour of sleep during a PSG or per hour of monitoring (respiratory polygraphy)

central sleep apnea (CSA)

PSG shows all of the following: 1. 5 or more central apneas and/or central hypopneas per hour of sleep. 2. The number of central and/or central hypopneas is \> 50% of the total number of apneas and hypopneas.

control

apnea-hypopnea index \< 5 per hour of sleep during a PSG or per hour of monitoring (respiratory polygraphy)

Eligibility Criteria

• Age: 19 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants who are suspected of sleep apnea due to symptoms such as snoring, witnessed apneas, waking up with a choking sensation, excessive sleepiness, non-restorative sleep, difficulty initiating or maintaining sleep, fatigue or tiredness, and morning headache will be prospectively recruited at the outpatient clinic of Seoul National University Hospital.

You may qualify if:

• Participants who are suspected of sleep apnea due to symptoms such as snoring, witnessed apneas, waking up with a choking sensation, excessive sleepiness, non-restorative sleep, difficulty initiating or maintaining sleep, fatigue or tiredness, and morning headache

You may not qualify if:

• None

Sponsors & Collaborators

• Seoul National University Hospital: lead

Study Sites (1)

Seoul National University Hospital

Seoul, 03080, South Korea

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

For only participants with the informed consent of donating blood, their blood samples (serum, plasma, and buffy coat) will be collected and stored in the Seoul National University Hospital-Human Biobank (SNUH-HUB).

MeSH Terms

Conditions

Sleep Apnea Syndromes

Condition Hierarchy (Ancestors)

Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases

Study Officials

• Jaeyoung Cho, M.D.

  Seoul National University Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jaeyoung Cho, M.D.

CONTACT

+82-2-2072-2503; apricot6@snu.ac.kr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: November 27, 2019
• First Posted: December 4, 2019
• Study Start: November 11, 2019
• Primary Completion (Estimated): December 1, 2045
• Study Completion (Estimated): December 1, 2046
• Last Updated: April 24, 2026

Record last verified: 2026-04

Locations

KR (1)