Sensorimotor Gating in Schizophrenia
1 other identifier
interventional
531
1 country
1
Brief Summary
This study is looking at problems people sometimes have taking in information from their senses. Specifically, we are comparing the way in which people diagnosed with schizophrenia process sound information, compared with people who have never been diagnosed with a psychiatric disorder. When people hear a loud sound they sometimes feel startled, and when they feel startled they usually blink their eyes. However, if they hear a softer sound shortly before the loud one they may not blink their eyes - in other words, the eye-blink response is smaller. When this happens it's called prepulse inhibition of startle. In this study, we want to measure the startle response and prepulse inhibition of startle in individuals diagnosed with schizophrenia versus individuals not diagnosed with schizophrenia. We also want to find out whether people show the same amount of prepulse inhibition of startle as other members of their family.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable schizophrenia
Started Jun 2001
Longer than P75 for not_applicable schizophrenia
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2001
CompletedFirst Submitted
Initial submission to the registry
November 20, 2007
CompletedFirst Posted
Study publicly available on registry
November 21, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 26, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
August 26, 2011
CompletedAugust 7, 2019
August 1, 2019
10.2 years
November 20, 2007
August 5, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Prepulse inhibition of acoustic startle
Day 1 Post-intervention
Study Arms (4)
1
EXPERIMENTALSubjects with schizophrenia
2
ACTIVE COMPARATORHealth controls
3
ACTIVE COMPARATORFamily members of subjects with schizophrenia
4
ACTIVE COMPARATORFamily members of healthy controls
Interventions
recording of eyeblink component of acoustic startle reflex with small surface electrodes during presentation of acoustic stimuli through headphones
Eligibility Criteria
You may qualify if:
- Diagnosis of a Schizophrenia Spectrum disorder OR no history of Psychiatric Illness
You may not qualify if:
- History of head injury with loss of consciousness of more than 5 minutes
- History of neurological disease (ex. meningitis, encephalitis)
- Drug or alcohol abuse within the last 3 months
- Hearing loss
- Non-correctable vision problems
- Current cancer treatment (radiation or chemotherapy currently ongoing)
- History of Post Traumatic Stress Disorder
- Diagnosis of HIV or AIDS
- Uncontrolled diabetes
- History of seizures
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Emory Universitylead
Study Sites (1)
Atlanta VA Medical Center
Decatur, Georgia, 30033, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Erica Duncan, MD
Atlanta VA Medical Center, Emory University Dept of Psychiatry & Behavioral Sciences
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
November 20, 2007
First Posted
November 21, 2007
Study Start
June 1, 2001
Primary Completion
August 26, 2011
Study Completion
August 26, 2011
Last Updated
August 7, 2019
Record last verified: 2019-08
Data Sharing
- IPD Sharing
- Will not share