Continuous Positive Airway Pressure on Tuberculosis Pleural Effusion

NCT00560521 | Completed DMC

• 1 other identifier: Oliveira-1
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Tuberculosis (TB) remains as an important public health problem worldwide. Pleural tuberculosis is the most prevalent form of extrapulmonary presentation in immunocompetent patients. The volume of effusion in the pleural space of patients with pleural TB may cause complications like restrictive ventilator lung functional disturb and/or pleural thickening. The respiratory physiotherapy can be adjuvant on treatment of pleural effusion tuberculosis throughout of various treatment technique. The Continuous positive airway pressure (CPAP) is utilized in various pathologic, this improves lung mechanics by recruiting atelectatic alveoli, improving pulmonary compliance, and reducing the work of breathing. The aim of this study is to determine the effect of CPAP on fluid absorption among patients with pleural effusion due tuberculosis.

Conditions

Tuberculosis; Pleural Effusion

Keywords

CPAP; Tuberculosis; Pleural effusion; Physiotherapy

Outcome Measures

Primary Outcomes (1)

• Evaluate of pleural effusion volume

  one month

Study Arms (1)

1

ACTIVE COMPARATOR

Behavioral: CPAP

Interventions

CPAP BEHAVIORAL

Frequency of three times a week, using a positive end expiratory pressure (PEEP) of 10 mmH2O for 30 minutes for four weeks.

1

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Confirmed diagnosis of pleural tuberculosis.
• Patients 18 years of age and older.

You may not qualify if:

• Be under previous treatment of respiratory physiotherapy.
• Irregular use or abandonment of the anti-TB standard regimen.
• To fail one or more physiotherapy section.
• To fail one or more radiological evaluation.

Sponsors & Collaborators

• Universidade Federal do Rio de Janeiro: lead

Study Sites (1)

Clementino Fraga Filho University Hospital- Federal University of Rio de Janeiro

Rio de Janeiro, Rio de Janeiro, 21941913, Brazil

Location

Related Publications (8)

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  PMID: 9778201 BACKGROUND

• Masip J. Non-invasive ventilation. Heart Fail Rev. 2007 Jun;12(2):119-24. doi: 10.1007/s10741-007-9012-7.

  PMID: 17492379 BACKGROUND

• Seiscento M, Conde MB, Dalcolmo MM. [Tuberculous pleural effusions]. J Bras Pneumol. 2006;32 Suppl 4:S174-81. doi: 10.1590/s1806-37132006000900003. Portuguese.

  PMID: 17273621 BACKGROUND

• Conde MB, Loivos AC, Rezende VM, Soares SL, Mello FC, Reingold AL, Daley CL, Kritski AL. Yield of sputum induction in the diagnosis of pleural tuberculosis. Am J Respir Crit Care Med. 2003 Mar 1;167(5):723-5. doi: 10.1164/rccm.2111019.

  PMID: 12598215 BACKGROUND

• Vandevenne A, Moyses B, Weitzenblum E, Carloz I, Methlin G. [Regional pulmonary function in unilateral sero-fibrinous pleural effusions and changes under the influence of treatment (author's transl)]. Poumon Coeur. 1981;37(3):223-8. French.

  PMID: 7301718 RESULT

• Ferrer J. Pleural tuberculosis. Eur Respir J. 1997 Apr;10(4):942-7.

  PMID: 9150338 RESULT

• Zhou A, Guo L, Tang L. Effect of an intrathoracic injection of sodium hyaluronic acid on the prevention of pleural thickening in excess fluid of tuberculous thoracic cavity. Clin Exp Pharmacol Physiol. 2003 Mar;30(3):203-5. doi: 10.1046/j.1440-1681.2003.03804.x.

  PMID: 12603352 RESULT

• Oliveira JF, Mello FC, Rodrigues RS, Boechat AL, Conde MB, Menezes SL. Effect of continuous positive airway pressure on fluid absorption among patients with pleural effusion due to tuberculosis. Rev Bras Fisioter. 2010 Mar-Apr;14(2):127-32. doi: 10.1590/s1413-35552010005000001. Epub 2010 Apr 30.

  PMID: 20464170 DERIVED

MeSH Terms

Conditions

Tuberculosis; Pleural Effusion

Condition Hierarchy (Ancestors)

Mycobacterium Infections; Actinomycetales Infections; Gram-Positive Bacterial Infections; Bacterial Infections; Bacterial Infections and Mycoses; Infections; Pleural Diseases; Respiratory Tract Diseases

Study Officials

• Juliana F Oliveira, MD

  Universidade Federal do Rio de Janeiro

  PRINCIPAL INVESTIGATOR

• Marcus B. Conde, PhD

  Universidade Federal do Rio de Janeiro

  PRINCIPAL INVESTIGATOR

• Rosana S. Rodrigues, MD

  Universidade Federal do Rio de Janeiro

  STUDY CHAIR

• Sara L. Menezes, PhD

  Universidade Federal do Rio de Janeiro

  PRINCIPAL INVESTIGATOR

• Ana L. Boechat, MD

  Universidade Federal do Rio de Janeiro

  STUDY CHAIR

• Fernanda C. Mello, PhD

  Universidade Federal do Rio de Janeiro

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: November 16, 2007
• First Posted: November 19, 2007
• Study Start: March 1, 2005
• Study Completion: March 1, 2007
• Last Updated: November 19, 2007

Record last verified: 2007-11

Locations

BR (1)