Study Stopped
Terminated by Sponsor
Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1)
COGENT-1
A Randomized, Double-Blind, Double-Dummy, Parallel Group, Phase 3 Efficacy and Safety Study of CGT-2168 Compared With Clopidogrel to Reduce Upper Gastrointestinal Events Including Bleeding and Symptomatic Ulcer Disease
2 other identifiers
interventional
5,000
16 countries
491
Brief Summary
The purpose of the COGENT-1 clinical trial is to determine whether CGT-2168 (clopidogrel and omeprazole) compared to clopidogrel is safe and effective in reducing the incidence of gastrointestinal bleeding and symptomatic ulcer disease, in the setting of concomitant aspirin therapy. Antiplatelet therapy is an essential element of care for patients with atherothrombotic disease. Bleeding is a fundamental adverse effect of all antiplatelet drugs including aspirin, clopidogrel and dual antiplatelet regimens. The gastrointestinal tract is the most common site of bleeding related to antiplatelet therapy, typically in connection with peptic ulcer disease. Recently published studies suggest the use of clopidogrel carries a gastrointestinal bleeding risk similar to that of aspirin or non-aspirin non-steroidal anti-inflammatory drugs. Patients taking any two of these drugs (clopidogrel, aspirin and/or non-aspirin NSAIDs) are exposed to an even higher risk of bleeding and ulcer disease. Cogentus Pharmaceuticals is launching phase 3 trials of a novel combination product, CGT-2168, which has the potential to significantly reduce this problem and increase patient safety. CGT-2168 combines a standard dosage of clopidogrel and a gastroprotectant (omeprazole) in a once-daily pill that may reduce the likelihood of adverse gastrointestinal events.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Dec 2007
491 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 12, 2007
CompletedFirst Posted
Study publicly available on registry
November 14, 2007
CompletedStudy Start
First participant enrolled
December 1, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2009
CompletedJanuary 28, 2009
January 1, 2009
1.9 years
November 12, 2007
January 27, 2009
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Composite of upper gastrointestinal clinical events, including gastroduodenal bleeding, symptomatic gastroduodenal ulcer, persistent pain with multiple gastric erosions, obstruction or perforation
Anticipated minimum of 48 weeks, up to end of study
Secondary Outcomes (6)
Composite of gastroduodenal bleeding, symptomatic gastroduodenal ulcer, obstruction or perforation
Anticipated minimum of 48 weeks, up to end of study
Composite of gastroduodenal bleeding, obstruction or perforation
Anticipated minimum of 48 weeks, up to end of study
Discontinuation of study medication attributed to gastrointestinal signs or symptoms
Anticipated minimum of 48 weeks, up to end of study
Gastroesophageal reflux disease, as evidenced by symptomatic endoscopically-confirmed erosive esophagitis
Anticipated minimum of 48 weeks, up to end of study
Dyspepsia, defined as an increase of at least ten points on the "pain intensity" component of the SODA instrument from baseline
Anticipated minimum of 48 weeks, up to end of study
- +1 more secondary outcomes
Study Arms (2)
1
EXPERIMENTAL2
ACTIVE COMPARATORInterventions
(CGT-2168 active and Comparator placebo, one capsule each daily; and enteric coated aspirin at daily dose level assigned by study physician)
(CGT-2168 placebo and Comparator active, one capsule each daily; and enteric coated aspirin at daily dose level assigned by study physician)
Eligibility Criteria
You may qualify if:
- Patients in whom a requirement for clopidogrel therapy with concomitant aspirin is anticipated for at least the next 12 months. Specific conditions that may confer a need for long-term clopidogrel + aspirin therapy may include non-ST segment elevation acute coronary syndrome (unstable angina/non-Q-wave MI), ST segment elevation acute MI), or new placement of a coronary artery stent.
- For women of childbearing potential, negative pregnancy test prior to randomization and agreement to use effective method of birth control during the study.
- Able to provide written informed consent based on competent mental status.
You may not qualify if:
- Patients currently hospitalized for whom discharge is not anticipated within 48 hours of randomization.
- Requirement for current or chronic use of a proton pump inhibitor, H2 receptor blocker, sucralfate or misoprostol.
- Erosive esophagitis, esophageal or gastric variceal disease, or non-endoscopic gastric surgery. Patients with a history of GERD/erosive esophagitis or dyspepsia who do not currently require proton pump blockers will be eligible.
- Receipt of \> 21 days of clopidogrel or another thienopyridine prior to randomization.
- Oral anticoagulation that cannot be safely discontinued for duration of study.
- Recent fibrinolytic therapy.
- Scheduled percutaneous coronary intervention (PCI). Patients may be enrolled upon completion of PCI.
- Recent (\< 30 days prior to randomization) or scheduled coronary artery bypass graft (CABG) surgery.
- Cardiogenic shock at time of randomization, refractory ventricular arrhythmias, or congestive heart failure (NY Heart Association class IV).
- Active pathological bleeding or a history of hereditary or acquired hemostatic disorder.
- History of hemorrhagic stroke, intracranial neoplasm, arteriovenous malformation or aneurysm.
- Systemic corticosteroids except low-dose oral corticosteroids equivalent to prednisone \< or equal to 5 mg/day.
- Allergy or contraindication to clopidogrel or other thienopyridine drugs, omeprazole or other proton pump inhibitor drugs, aspirin or salicylate derivatives, or other study drug ingredients.
- Treatment within 30 days prior to randomization with any investigational drug or device including investigational coronary artery stents or currently enrolled in another interventional drug or device study.
- Women who are pregnant or breastfeeding.
- +2 more criteria
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (491)
Alabama Clinical Research Institute, Inc. (ACRI)
Alexander City, Alabama, 35010, United States
Alabama Clinical Therapeutics, LLC
Birmingham, Alabama, 35126, United States
Cardio-Thoracic Surgeons P.C.
Birmingham, Alabama, 35213, United States
Birmingham Heart Clinic, PC
Birmingham, Alabama, 35235, United States
John F Simmons , MD PC
Geneva, Alabama, 36340, United States
Clinical Research Consultants, Inc.
Hoover, Alabama, 35216, United States
The Heart Center, PC
Huntsville, Alabama, 35801, United States
Mobile Heart Specialists, PC
Mobile, Alabama, 36608, United States
Advanced Cardiac Specialists
Mesa, Arizona, 85206, United States
Redpoint Research
Phoenix, Arizona, 85029, United States
Cardiovascular Consultants, Ltd.
Phoenix, Arizona, 85032, United States
Cochise Clinical Research
Sierra Vista, Arizona, 85635, United States
Paradigm Clinical Research, Inc.
Tucson, Arizona, 85705, United States
Tri-Lakes Research
Hot Springs, Arkansas, 71901, United States
Michael A. Frais, Cardiologist, P.A.
Hot Springs, Arkansas, 71913, United States
NEA-Clinic Cardiology
Jonesboro, Arkansas, 72401, United States
Searcy Medical Center
Searcy, Arkansas, 72143, United States
Cardiology Consultants of Orange County
Anaheim, California, 92801, United States
Chest and Critical Care Consultants, A Medical Group
Anaheim, California, 92801, United States
Clinical Solutions Advantage
Buena Park, California, 90620, United States
Turns Institute for Clinical Research
Castro Valley, California, 94546, United States
Escondido Cardiology Associates
Escondido, California, 92025, United States
Accurate Clinical Trials, Inc.
Laguna Hills, California, 92653, United States
Therapeutic Research Institute of Orange County
Laguna Hills, California, 92653, United States
Kirtik Thaker MD
Lakewood, California, 90712, United States
Los Angeles Cardiology Associates
Los Angeles, California, 90017, United States
Merced Heart Associates
Merced, California, 95348, United States
Mission Internal Medical Group
Mission Viejo, California, 92691, United States
Altos Cardiovascular Associates
Mountain View, California, 94040, United States
Kenneth W. Carr, MD, Cardiology
Oceanside, California, 92056, United States
Rancho CucamongaClinical Trials
Rancho Cucamonga, California, 91703, United States
Inland Heart and Vascular Medical Associates
San Bernardino, California, 92404, United States
Ritchken and First
San Diego, California, 92117, United States
Rider Research Group
San Francisco, California, 94117, United States
Richard Levy, MD.
San Francisco, California, 94118, United States
Kaiser Permanente
San Jose, California, 95119, United States
Medical Helping Hands Research
Santa Ana, California, 92704, United States
Pacific Heart Institute
Santa Monica, California, 90404, United States
Radiant Research
Santa Rosa, California, 95405, United States
Harbor- UCLA Medical Center
Torrance, California, 90509, United States
Ventura Cardiology Consultants Medical Group, Inc.
Ventura, California, 93003, United States
Colorado Springs Health Partners
Colorado Springs, Colorado, 80907, United States
Connecticut Clinical Research
Bridgeport, Connecticut, 06606, United States
Hartford Hospital
Hartford, Connecticut, 06102, United States
Alfieri Cardiology, PA
Newark, Delaware, 19713, United States
Washington V.A. Medical Center
Washington D.C., District of Columbia, 20422, United States
Oscar R. Guerra, MD PA
Coral Gables, Florida, 33134, United States
Deerfield Beach Cardiology Associates
Deerfield Beach, Florida, 33442, United States
Dr Jules Cohen
Hallandale, Florida, 33009, United States
Empire International Research
Hialeah, Florida, 33012, United States
Cardiovascular Consultants of South Florida
Hollywood, Florida, 33021, United States
Jacksonville Heart Center
Jacksonville, Florida, 32207, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, 32216, United States
Jacksonville Heart Center
Jacksonville, Florida, 32250, United States
CVMS Resesarch Institute, LLC
Jupiter, Florida, 33458, United States
Watson Clinic Center for Research
Lakeland, Florida, 33805, United States
Alpha Medical Research, LLC
Melbourne, Florida, 32901, United States
Empire International Research
Miami, Florida, 33125, United States
Suncoast Research Group, LLC
Miami, Florida, 33144, United States
Cardiovascular Research Center of South Florida
Miami, Florida, 33173, United States
Research Center Phase I-IV of Florida Corp.
Miami, Florida, 33175, United States
Empire International Research
Miami, Florida, 33186, United States
Bert Fish Medical Center
New Smyrna Beach, Florida, 32168, United States
Central Florida Cardiology Group
Orlando, Florida, 32803, United States
Cardiology Assocaites of Orlando d/b/a Orlando Heart Center
Orlando, Florida, 32806, United States
Sunset Point Medical Associates
Palm Harbor, Florida, 34684, United States
Berma Research Group
Plantation, Florida, 33317, United States
Charlotte Heart Group Research Center
Port Charlotte, Florida, 33952, United States
Suncoast Cardiovascular Research
St. Petersburg, Florida, 33701, United States
The Heart and Vascular Institute of Florida
St. Petersburg, Florida, 33709, United States
G&G Research Baker-Tombul Cardiology
Vero Beach, Florida, 32960, United States
Carlos Levy, D.O.
Weston, Florida, 33326, United States
Piedmont Hospital
Atlanta, Georgia, 30309, United States
Primary Care Specialists, LLC/ ECAST CT
Atlanta, Georgia, 30312, United States
Executive Health and Research Associates, Inc.
Atlanta, Georgia, 30342, United States
Southeast Regional Research Group
Columbus, Georgia, 31904, United States
Georgia Heart Specialists, LLC
Covington, Georgia, 30014, United States
Ialum Clinical Research Center, LLC
Decatur, Georgia, 30032, United States
Ialum Clinical Research Center
Decatur, Georgia, 30032, United States
Ialum Clinical Research Center
Decatur, Georgia, 30035, United States
Southeast Regional Research Group
Savannah, Georgia, 31406, United States
Medsouth Primary CareStockbridge
Stockbridge, Georgia, 30281, United States
South Suburban Health Professional Group, PC
Flossmoor, Illinois, 60422, United States
Consultants in Cardiovascular Medicine
Melrose Park, Illinois, 60160, United States
Methodist Medical Center of Illinois
Peoria, Illinois, 61606, United States
Community Clinical Research Center
Anderson, Indiana, 46011, United States
American Health Network
Avon, Indiana, 46123, United States
Indiana Medical Research
Elkhart, Indiana, 46514, United States
Welborn Clinic
Evansville, Indiana, 47713, United States
Indiana Heart Physicians
Indianapolis, Indiana, 46237, United States
Midwest Cardiovascular Research Foundation
Davenport, Iowa, 52803, United States
Northeast Iowa Medical Education Foundation
Waterloo, Iowa, 50702, United States
Hutchinson Clinic, P.A.
Hutchinson, Kansas, 67502, United States
Venture Resource Group, Inc.
Mission, Kansas, 66202, United States
Midwest Cardiology Assocaites
Overland Park, Kansas, 66209, United States
Cumberland Cardiology
Ashland, Kentucky, 41101, United States
Trover Health System
Madisonville, Kentucky, 42431, United States
Owensboro Heart and Vascular
Owensboro, Kentucky, 42303, United States
Dolby Research, LLC
Baton Rouge, Louisiana, 33437, United States
Cardiovascular Institute of the South
Houma, Louisiana, 70301, United States
Heart Clinic of Louisiana Clinical Research, LLC.
Marrero, Louisiana, 70072, United States
Maine Research Associates
Auburn, Maine, 04210, United States
Cardiovascular Consultants of Maine, PA
Scarborough, Maine, 04074, United States
Maine Cardiology Associates
South Portland, Maine, 04106, United States
Good Samaritan Hospital (Medstar Health)
Baltimore, Maryland, 21239, United States
eCast Corporation
Greenbelt, Maryland, 20770, United States
Atlantic Cardiology Associates, P.A
Salisbury, Maryland, 21801, United States
Peninsula Cardiology Associates
Salisbury, Maryland, 21804, United States
Pentucket Medical Associates
Haverhill, Massachusetts, 01830, United States
Charles River Medical Associates
Natick, Massachusetts, 01760, United States
Michigan Cardiovascular Institute
Bay City, Michigan, 48708, United States
Apex Medical Research, AMR, Inc.
Flint, Michigan, 48504, United States
Borgess Research Institute
Kalamazoo, Michigan, 49048, United States
Michigan Cardiovascular Institute
Midland, Michigan, 48670, United States
Michigan Cardiovascular Institute
Saginaw, Michigan, 48601, United States
Covenant Medical Center, Inc.
Saginaw, Michigan, 48602, United States
Academic Heart and Vascular PLLC
Saint Clair Shores, Michigan, 48081, United States
Oakland Medical Center
Troy, Michigan, 48085, United States
Waterford Medical Assoc. P.C.
Waterford, Michigan, 48328, United States
Michigan Heart, PC
Ypsilanti, Michigan, 48106, United States
Duluth Clinic / Saint Marys Medical Center
Duluth, Minnesota, 55805, United States
University of Minnesota
Minneapolis, Minnesota, 55455, United States
Regions Hospital
Saint Paul, Minnesota, 55101, United States
New Coast Cardiology Center, PLLC
Gulfport, Mississippi, 39503, United States
PPS Clinical Research, STL, LLC
Chesterfield, Missouri, 63017, United States
Kansas City VA Medical Center
Kansas City, Missouri, 64128, United States
Cardiology Diagnostics, Ltd.
St Louis, Missouri, 63122, United States
Glacier View Cardiology
Kalispell, Montana, 59901, United States
Saint Patrick Hospital- International Heart Institute of Montana
Missoula, Montana, 59802, United States
The Creighton Cardiac Center
Omaha, Nebraska, 68131, United States
Alegent Health Clinic Heart and Vascular Specialist
Papillion, Nebraska, 68046, United States
Nevada Cardiology Associates
Las Vegas, Nevada, 89128, United States
Lahey Cardiology @ the Medical Center
Nashua, New Hampshire, 03060, United States
Associated Cardiovascular Consultants
Cherry Hill, New Jersey, 08034, United States
Cardiovascular Associates of the Delaware Valley, P.A.
Elmer, New Jersey, 08318, United States
Cardiovascular Associates of the Delaware Valley, P.A.
Haddon Heights, New Jersey, 08035, United States
Cardiovascular Associates of the Delaware Valley, P.A.
Sewell, New Jersey, 08080, United States
Physicans Research Center, LLC
Toms River, New Jersey, 08755, United States
Capital Cardiology Associates
Albany, New York, 12211, United States
Hudson Valley Cardiology Group, P.C.
Cortlandt Manor, New York, 10567, United States
Cardiology Associates, P.C.
Johnson City, New York, 13790, United States
Long Island Heart Associates
Mineola, New York, 11501, United States
Slocum-Dickson Medical Group, PLLC
New Hartford, New York, 13413, United States
Sound Shore Cardiology, P.C.
New Rochelle, New York, 10801, United States
New York Cardiovascular Associate
New York, New York, 10001, United States
St. Luke's- Roosevelt Hospital
New York, New York, 10025, United States
Rochester General Hospital
Rochester, New York, 14621, United States
Saratoga Cardiology Assoc, PC
Saratoga Springs, New York, 12866, United States
Westchester Cardiology Associates
Scarsdale, New York, 10583, United States
Good Samaritan Hospital
Suffern, New York, 10901, United States
Cardiology, PC
Syracuse, New York, 13210, United States
SUNY Upstate Medical University
Syracuse, New York, 13210, United States
Cardiac Care and Vascular Medicine, Albert Einstein College of Medicine
The Bronx, New York, 10469, United States
Capital Cardiology Associates
Troy, New York, 12180, United States
Buffalo Cardiology and Pulmonary Associates
Williamsville, New York, 14221, United States
Mark J. Kozinn, MD
Williamsville, New York, 14221, United States
Clinical Study Center of Asheville, LLC
Asheville, North Carolina, 28803, United States
Kernodle Clinic, Inc.
Burlington, North Carolina, 27215, United States
Metrolina Medical Research
Charlotte, North Carolina, 28209, United States
Diversified Research
Durham, North Carolina, 27704, United States
Cumberland Research Associates, LLC
Fayetteville, North Carolina, 28304, United States
Cardiovascular Care of Northern Carolina
Oxford, North Carolina, 27565, United States
St. Alexius Medical Center
Bismarck, North Dakota, 58501, United States
Altru Health Systems
Grand Forks, North Dakota, 58201, United States
Trinity Health
Minot, North Dakota, 58701, United States
George G. Ellis, Jr. M.D., Inc.
Boardman, Ohio, 44512, United States
Cardiovascular Research Institute, LLC
Canton, Ohio, 44710, United States
Comprehensive Cardiology Consultants, Inc.
Cincinnati, Ohio, 45236, United States
Midwest Cardiology Research Foundation
Columbus, Ohio, 43214, United States
Prestige Clinical Research
Franklin, Ohio, 45005, United States
St. Vincent Mercy Medical Center
Toledo, Ohio, 43608, United States
Cardiology Associates of SE Ohio, Inc
Zanesville, Ohio, 43701, United States
Physicans Research, Inc.
Zanesville, Ohio, 43701, United States
Bluestem Cardiology Research Dept.
Bartlesville, Oklahoma, 74006, United States
Oklahoma Cardiovascular Research Group
Oklahoma City, Oklahoma, 73109, United States
Aquilo Research
Yukon, Oklahoma, 73099, United States
Bend Memorial Clinic
Bend, Oregon, 97701, United States
Hillsboro Cardiology, PC
Hillsboro, Oregon, 97123, United States
Legacy Clinical Research
Portland, Oregon, 97210, United States
Abington Medical Specialists
Abington, Pennsylvania, 19001, United States
Tri-State Medical Group
Beaver, Pennsylvania, 15009, United States
Heritage Cardiology Association
Camp Hill, Pennsylvania, 17011, United States
Premier Heart Specialists
Easton, Pennsylvania, 18042, United States
Heart Specialists of Lancaster
Ephrata, Pennsylvania, 17522, United States
Penn State Hershey Medical Center
Hershey, Pennsylvania, 17033, United States
Pennsylvania Heart and Vascular Group, P.C.
Jenkintown, Pennsylvania, 19046, United States
Comprehensive Cardiology Consultants
Langhorne, Pennsylvania, 19047, United States
Sewickley Valley Medical Group Cardiology
Leetsdale, Pennsylvania, 15056, United States
Cardiology Consultants of Philadelphia
Norristown, Pennsylvania, 19401, United States
Hospital of the University of Pennsylvania Cardiology Department
Philadelphia, Pennsylvania, 19104, United States
Cardiology Consultants of Philadelphia
Philadelphia, Pennsylvania, 19111, United States
Albert Einstein Medical Center
Philadelphia, Pennsylvania, 19141, United States
Cardiology Consultants of Philadelphia
Philadelphia, Pennsylvania, 19148, United States
VA Pittsburgh Healthcare System
Pittsburgh, Pennsylvania, 15240, United States
Advanced Cardiology Specialists
Scranton, Pennsylvania, 18501, United States
Elite Medical Research, Inc.
Sellersville, Pennsylvania, 18960, United States
Cardiology Consultants of Philadelphia
Upland, Pennsylvania, 19013, United States
West Chester Cardiology, PC
West Chester, Pennsylvania, 19380, United States
Berks Cardiology, Ltd.
Wyomissing, Pennsylvania, 19610, United States
Cardiology Consultants of Philadelphia
Yardley, Pennsylvania, 19067, United States
New England Center for Clinical Research, Inc
Cranston, Rhode Island, 02920, United States
Rhode Island Hospital Cardiology
Providence, Rhode Island, 02903, United States
Cardiology Specialists
Westerly, Rhode Island, 02891, United States
Palmetto Clinical Research
Summerville, South Carolina, 29485, United States
McMinn Medical Group (DBA: Athens Medical Group)
Athens, Tennessee, 37303, United States
Verzosa & Ungab Internal Medicine Associates
Bartlett, Tennessee, 38134, United States
Middle Tennessee Clinical Research
Fayetteville, Tennessee, 37334, United States
Research Associates of Jackson and Apex Cardiology
Jackson, Tennessee, 38301, United States
Tri-State Cardiology
Johnson City, Tennessee, 37601, United States
Memphis Internal Medicine
Memphis, Tennessee, 38119, United States
Goodlife Medical Center
Memphis, Tennessee, 38120, United States
Heart and Vascular Clinic
Nashville, Tennessee, 37203, United States
Family Health Care Assoc.
Arlington, Texas, 76013, United States
Southeast Texas Clinical Research Center
Beaumont, Texas, 77702, United States
Trinity Hypertension and Diagnostic Res.
Carrollton, Texas, 75006, United States
VA Medical Center
Dallas, Texas, 75216, United States
U.T. Southwestern
Dallas, Texas, 75390, United States
Amir Malik Research
Fort Worth, Texas, 76104, United States
The University of Texas Medical Branch at Galveston
Galveston, Texas, 77555-0553, United States
East Texas Cardiology PA
Houston, Texas, 77002, United States
Office of Amer Zaheer, MD
Houston, Texas, 77004, United States
Office of Salim Gopalani, MD
Houston, Texas, 77008, United States
Comprehensive Heart Care, PA
Houston, Texas, 77024, United States
Century Clinical Research
Houston, Texas, 77036, United States
Office of Mizra Basith Baig, MD
Houston, Texas, 77055, United States
Covenant Cardiology Associates
Lubbock, Texas, 79410, United States
South Texas Institutes of Health
McAllen, Texas, 78572, United States
Texas Regional Heart Center d/b/a Legacy Heart Center
Plano, Texas, 75024, United States
Heart & Vascular Institute of Texas
San Antonio, Texas, 78217, United States
Cardiology Clinic of San Antonio
San Antonio, Texas, 78229, United States
South Texas Cardiovascular Consultants
San Antonio, Texas, 78229, United States
IMED Research, PA
San Antonio, Texas, 78258, United States
Southwest Health Associate, PA
Sugar Land, Texas, 77478, United States
Office of Dwayne O. Williams, MD
Sugarland, Texas, 77479, United States
Kings Daughters Clinic
Temple, Texas, 76502, United States
Victoria Heart and Vascular Center
Victoria, Texas, 77901, United States
Cardiology Consultants of Danville
Danville, Virginia, 24541, United States
Triad Research Institute
Galax, Virginia, 24333, United States
Virginia Cardiovascular Specialists
Richmond, Virginia, 23226, United States
Winchester Medical Center/ Clinical Research Department
Winchester, Virginia, 22601, United States
Daniel W. Gottlieb, MD, PS
Burien, Washington, 98166, United States
Heart Clinic Northwest
Spokane, Washington, 99204, United States
Inland Cardiology Assocaites
Spokane, Washington, 99204, United States
Franciscan Health System dba FHS Research Center
Tacoma, Washington, 98405, United States
Parkersburg Cardiology Associates
Parkersburg, West Virginia, 26101, United States
Wisconsin Heart, S.C.
Madison, Wisconsin, 53715, United States
Heart Care Associates, LLC
Milwaukee, Wisconsin, 53215, United States
The Canberra Hospital
Garran, Australian Capital Territory, 2605, Australia
Coffs Harbour Cardiology
Coffs Harbour, New South Wales, 2450, Australia
Cardiac Research Institute
Eastwood, New South Wales, 2122, Australia
Wesley research institute
Auchenflower, Queensland, 4066, Australia
Cairns Base Hospital
Cairns, Queensland, 4870, Australia
Royal Brisbane and Women's Hospital
Herston, Queensland, 4029, Australia
Royal Hobart Hospital
Hobart, Tasmania, 7001, Australia
Launceston General Hospital
Launceston, Tasmania, 7250, Australia
Northern Hospital
Epping, Victoria, 3076, Australia
St.Vincent's Hospital (Melb)
Fitzroy, Victoria, 3065, Australia
Geelong Hospital- Barwon Health
Geelong, Victoria, 3220, Australia
Fremantle Hospital
Fremantle, Western Australia, 6160, Australia
Multiprofile Hospital for Active Treatment "Sveta Ekaterina", 1st Department of Internal Diseases
Dimitrovgrad, Bulgaria
Multiprofile Hospital for Active Treatment "Dr. Georgi Stranski, Clinic of Cardiology
Pleven, Bulgaria
Multiprofile Hospital for Active Treatment ''Sveti Georgi'', Cardiology Clinic
Plovdiv, Bulgaria
Multiprofile Hospital for Active Treatment ''Sveti Panteleymon'', 2nd Department. of Internal Diseases - Intensive Cardiology Unit
Plovdiv, Bulgaria
Multiprofile Hospital for Active Treatment - Ruse, 4th Department of Internal Diseases
Rousse, Bulgaria
4th Multiprofile Hospital for Active Treatment
Sofia, Bulgaria
Military Medical Academy, Clinic of Cardiology and Intensive Care
Sofia, Bulgaria
Multiprofile Hospital for Active Treatment and Emergency Medicine "Pirogov". Cardiology Clinic
Sofia, Bulgaria
National Heart Hospital Department of Cardiology
Sofia, Bulgaria
National Multiprofile Transport Hospital "Tsar Boris III, Cardiology Clinic
Sofia, Bulgaria
Tokuda Hospital Department of Cardiology
Sofia, Bulgaria
University Multiprofile Hospital for Active Treatment ''Tsaritsa Ioanna'' - ISUL, Cardiology Clinic
Sofia, Bulgaria
Multiprofile Hospital for Active Treatment "Sveta Marina", Clinic of Internal Diseases - 2nd Internal Department
Varna, Bulgaria
Dr. Tsui
Maple Ridge, British Columbia, V2X 5Z6, Canada
Fraser Clinical Trials Inc and Royal Columbian Hospital
New Westminster, British Columbia, V3L3W4, Canada
Vancouver General Hospital
Vancouver, British Columbia, V5Z 1M9, Canada
Victoria Heart Institute Foundation
Victoria, British Columbia, V8R4R2, Canada
Health Sciences Centre
Winnipeg, Manitoba, R3A1R9, Canada
South East Regional Health Authority
Moncton, New Brunswick, E1C4B7, Canada
Commonwealth Medical Clinic
Mount Pearl, Newfoundland and Labrador, A1N1W7, Canada
Cambridge Cardiac Care Centre
Cambridge, Ontario, NIR-6V6, Canada
Mississauga Clinical Research Center
Mississauga, Ontario, L5B2P7, Canada
Dr. George Zimakas
Niagara Falls, Ontario, L2G5X7, Canada
Dr. James Y. Cha
Oshawa, Ontario, L1J2K1, Canada
Curans Health Center
Thunder Bay, Ontario, P7R2Z3, Canada
Toronto East Cardiology Associates Inc.
Toronto, Ontario, M4C-1N2, Canada
Recherches Cliniques Theradev
Granby, Quebec, J2G8Z9, Canada
ViaCar Recherche Clinique Inc.
Greenfield Park, Quebec, J4N1L6, Canada
ViaCar Recherche Clinique Inc
Longueuil, Quebec, J4N1L6, Canada
Hospitalier de l'Universite de Montreal Hotel Dieu
Montreal, Quebec, H2W 1T8, Canada
Sacre-Coeur Hospital
Montreal, Quebec, H4J1C5, Canada
Centre Hospitalier Universitaire de Quebec (CHOQ) Hotel Dieu de Quebec
Québec, Quebec, G1R2J6, Canada
Laval Hospital
Québec, Quebec, G1V4G5, Canada
Centre Hospitalier Beauce-Etchemin
Saint George, Quebec, G5Y5B7, Canada
Centre de Sante et de services sociaux du nord de lanaudiere/CHRDL
Saint-Charles-Borromée, Quebec, J6E6J2, Canada
Clinique de Cardiologie de Trois-Rivieres
Trois-Rivières, Quebec, G8Z 3R9, Canada
Cardiology and Research
Westmount, Quebec, H3Z2M6, Canada
Clinica Antofagasta
Antofagasta, Chile
Corporación de Beneficencia Osorno
Osorno, Chile
Hospital Regional de Punta Arenas Dr. Lautaro Navarro
Punta Arenas, Chile
Complejo Asistencial Dr.Sótero del Río
Santiago, 8207257, Chile
Hospital del Salvador
Santiago, Chile
Instituto Nacional del Tórax
Santiago, Chile
Centro de Estudios Cardiovascular
Temuco, Chile
Clínica Reñaca
Viña del Mar, Chile
Hospital Dr. Gustavo Fricke
Viña del Mar, Chile
Hospital Naval Almirante Neff
Viña del Mar, Chile
Nemocnice ve Frydku-Mistku
Frýdek-Místek, 738 18, Czechia
Fakultni nemocnice Hradec Kralove
Hradec Králové, 500 05, Czechia
Krajska nemocnice Liberec, a. s.
Liberec, 460 63, Czechia
Litomyslska nemocnice a. s.
Litomyšl, 570 14, Czechia
Kardiologická ambulance
Ostrava, 702 00, Czechia
Kardiologicka a angiologicka ambulance
Ostrava Vítkovice, 703 00, Czechia
Pardubicka krajska nemocnice, a.s.
Pardubice, 532 03, Czechia
II.interni klinika kardiologie a angiologie 1. LF UK a VFN v Praze
Prague, 12808, Czechia
Klinika kardiologie Institut klinické a experimentální medicíny
Prague, 140 21, Czechia
Krajská nemocnice T. Bati a.s.
Zlín, 762 75, Czechia
Nemocnice Znojmo, p.o.
Znojmo, 669 02, Czechia
Centre Hospitalier d'Albi
Albi, 81000, France
Centre de Cardiologie CHRU Dijon
Dijon, 21079, France
Clinique Pasteur
Essey-lès-Nancy, 54270, France
CHRU de Lille Hôpital Cardiologique
Lille, 59037, France
Hôpital La Timone-Adultes
Marseille, 13385, France
Hôpital Lariboisière
Paris, 75010, France
La Pitié Salpétrière Institut de Cardiologie
Paris, 75651, France
Centre Hospitalier Intercommunal du Val d'Ariège
Saint-Jean-de-Verges, 09000, France
Centre Hospitalier Rangueil Larrey
Toulouse, 31403, France
Universitatsklinikum Berlin Campus Charite Mitte Med Klinik Kardiologie und Angiologie
Berlin, 10117, Germany
Vivantes Clinic Neuköln Berlin
Berlin, 12351, Germany
Vivantes Humbolt Klinikum
Berlin, 13509, Germany
Praxis Dr. med. Boscher
Biberach, 88400, Germany
St. Josef-Hospital Medizinische Klinik II, Kardiologie
Bochum, 44791, Germany
St.-Marien-Hospital Bonn
Bonn, 53115, Germany
Städtisches Klinikum Brandenburg GmbH
Brandenburg, 14770, Germany
MVZ am Küchwald GmbH
Chemnitz, 09113, Germany
Kliniken der Stadt Köln, Köln Merheim
Cologne, 53109, Germany
Gemeinschaftspraxis Innere Medizin und Kardiologie
Dinslaken, 46535, Germany
St.-Johannes-Hospital Dortmund
Dortmund, 44137, Germany
Zentrum für klinische Prüfungen in der Facharztzentrum Dresden Neustadt GbR
Dresden, 1099, Germany
Practice of Cardiology
Erfurt, 990804, Germany
Elisabeth.Krankenhaus
Essen, 45138, Germany
Asklepios Klinik St.Georg
Hamburg, 20099, Germany
Asklepios Klinik Barmbek
Hamburg, 22291, Germany
Universitäres Herz-und Gefäßzentrum Hamburg"
Hamburg, 22527, Germany
Kardiologische Praxis Hamburg Altona
Hamburg, 22765, Germany
Klinikum Region Hannover Krankenhaus Nordstadt
Hanover, 30167, Germany
Kardiologische Gemeinschaftspraxis
Hartmannsdorf, 09232, Germany
SRH Klinikum Karlsbad-Langensteinbach
Karlsbad, 76307, Germany
Herzzentrum Lahr
Lahr, 77933, Germany
Kardiologische Gemeinschaftpraxis
Leipzig, 04103, Germany
Universität Leipzig - Herzzentrum
Leipzig, 04289, Germany
Dr. THomas Klingenheben
Lengsdorf, 53127, Germany
Praxis für Innere Medizin, Gastroenterologie
Ludwigshafen, 67067, Germany
Universitätsklinikum Lübeck
Lübeck, 23538, Germany
Gemeinschaftspraxis
Lüneburg, 21339, Germany
Klinikum der Johannes-Gutenberg-Universität
Mainz, 55131, Germany
Gemeinschaftspraxis
Mannheim, 68165, Germany
Klinikum Mannheim GmbH, Universaitatskinikum
Mannheim, 68167, Germany
Kardiologische Praxis
Markkleeberg, 04416, Germany
Asklepios Klinik Melsungen
Melsungen, 34212, Germany
Kilniken Maria Hilf GmbH Krankenhaus St. Franziskus
Mönchengladbach, 41063, Germany
Internist/Kardiologe/Angiologe
Mühldorf A.d. Inn, 84453, Germany
Kardiologische Gemeinschaftspraxis
Nienburg, 31582, Germany
Klinikum Pirna GmbH
Pirna, 01796, Germany
Universitätsklinik Regensburg
Regensburg, 93053, Germany
Krankenhaus Reinbek St. Adolf-Stift
Reinbek, 21465, Germany
Kardiologische Gemeinschaftspraxis
Riesa, 01589, Germany
Internistische Praxis
Rottweil, 78628, Germany
Zentrum für Prävention und Rehabilation
Siegen, 57072, Germany
Marienkrankenhaus Soest
Soest, 59494, Germany
Praxisgemeinschaft Stuhr-Brinkum
Stuhr, 28816, Germany
Medizinische Universitätsklinik
Tübingen, 72076, Germany
Josephs-Hospital Warendorf
Warendorf, 48231, Germany
Kardiologische Praxis
Wermsdorf, 04779, Germany
Dr. Andreas Schreckenberg
Weyhe-Leeste, 28844, Germany
ForschungsZentrum Ruhr
Witten, 58455, Germany
Helios Klinikum Wuppertal
Wuppertal, 42117, Germany
Bajai Kórház
Baja, H-6500, Hungary
Budai Irgalmasrendi Kórház
Budapest, H-1027, Hungary
Fővárosi Önkormányzat Károlyi Sándor Kórház és Rendelőintézet
Budapest, H-1041, Hungary
Fovarosi Onkormanyzat Egyesitett Szent Istvan es Szent Laszlo Korhaz - Rendelointezet
Budapest, H-1096, Hungary
Városi Önkormányzat Kórház-Rendelőintézet
Kalocsa, H-6300, Hungary
Szabolcs-Szatmár-Bereg Megyei Önkormányzat Jósa András Oktató Kórház
Nyíregyháza, H-4400, Hungary
Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház
Toszegi, H-5004, Hungary
Jávorszky Ödön Kórház
Vác, H-2600, Hungary
Zala Megyei Kórház
Zalaegerszeg, H-8900, Hungary
Ospedali Riuniti di bergamo
Bergamo, 24128, Italy
Azienda Ospedaliera della Provincia di Lodi Presidio Ospedaliero di Codogno
Codogno (Lodi), 26845, Italy
Azienda Ospedaliera Universitaria San Martino-Dipartimento di Medicina Interna e Specialità Mediche
Genova, 16132, Italy
Azienda Ospeedaliera Carlo Poma
Mantova, 46100, Italy
Azienda Ospedaliera Maggiore Della Carita' Di Novara
Novara, 28100, Italy
Istituto Clinico Humanitas
Rozzano (Milano), 20089, Italy
Hospital de Jesus
D. F., D. F., cp 06090, Mexico
Hospital "Valentín Gómez Farías"
Guadalajara, Jalisco, 44600, Mexico
Instituto de Corazón de Querétaro, S.A. de C.V.
Querétaro City, Querétaro, 76178, Mexico
Cardioarritmias e Investigación, S.C.
San Luis Potosí City, San Lusi Potosi, 78200, Mexico
Hospital Cardiológica Aguascalientes
Aguascalientes, 20230, Mexico
Cardioprevent
Durango, C. P 34080, Mexico
Hospital Angeles de Puebla
Puebla City, 72190', Mexico
Hospital General de Puebla
Puebla City, 72490, Mexico
Hospital Central "Dr. Ignacio Morones Prieto"
San Luis Potosí City, 78240, Mexico
Oddział Kardiologii z Zakładem Diagnostyki Kardiologicznej, Samodzielny Publiczny Zakład Opieki Zdrowotnej, Wojewódzki Szpital im. dr J. Biziela,
Bydgoszcz, 85-168, Poland
NZOZ "Medicus" Jacek Kubica
Bydgoszcz, 85-435, Poland
Wojewódzki Szpital Meijski im. Biziela, Oddział Kardiologii - SPZOZ
Bydgoszcz, 85-826, Poland
Oddział Chorób Wewnętrzych i Kardiologii , ZOZ w Debicy
Dębica, 39-200, Poland
Zakład Opieki Zdrowotnej Trójmiejskie Centrum Medyczne Sp. z o.o
Gdansk, 80-437, Poland
Gabinet Kardiologiczny Medipuls
Gdynia, 81-423, Poland
Gabinet Kardiologiczno-Internistyczny
Gdynia, 81-472, Poland
Centrum Leczenia Chorób Cywilizacyjnych Oddz. Gdynia filla Fikakowo
Gdynia, 81-572, Poland
NZOZ Medicus, Poradnia Kardiologiczna
Gliwice, 44-100, Poland
Oddział Kardiologii i INK, SPZOZ nr 1
Gliwice, 44-100, Poland
Mazowieckie Centrum Badań Klinicznych Iwona Czajkowska, Monika Śmietańska s.c.
Grodzisk Mazowiecki, 05-825, Poland
Publiczny Specjalistyczny Zaklad Opieki Zdrowotnej Oddzial Kardiologiczny
Inowrocław, 88-100, Poland
Oddział Chorób Wewnętrznych i Farmakologii Klinicznej Samodzielny Publiczny Centralny Szpital Kliniczny im. Prof. Kornela Gibińskiego Śląskiego Uniwersytetu Medycznego w Katowicach
Katowice, 40-752, Poland
Szpital Specjalistyczny w Kościerzynie, Oddział Kardiologii
Kościerzyna, 83-400, Poland
Oddział Kardiologii, Szpital Specjalistyczny im. J. Dietla
Krakow, 31-121, Poland
"Klinika Choroby Wieńcowej Instytut Kardiologii, Collegium Medicum Uniwerytet Jagielloński
Krakow, 31-202, Poland
Oddzial Chorób Wewnętrznych III Szpital Specjalistyczny im.Stefana Zeromskiego, SPZOZ w Krakowie
Krakow, 31-913, Poland
Niepubliczny Zakład Opieki Zdrowotnej Specjalista Sp. z o.o.
Kutno, 99-300, Poland
Poradnia Kardiologiczna, Oddział Chorob Wewnetrznych Szpital Powiatowy w Limanowej
Limanowa, 34-600, Poland
Niepubliczny Zakład Opieki Zdrowotnej POLIMEDICA
Lodz, 90-302, Poland
All-Med Centrum Medyczne
Lodz, 94-050, Poland
Oddział Internistyczno-Kardiologiczny Samodzielny Publiczny Zakład Opieki Zdrowotnej
Lubartów, 21-100, Poland
"Oddzial Chorob Wewnetrznych i Kardiologii, Szpital Powiatowy im.Edmunda Biernackiego
Mielec, 39-300, Poland
Oddział Kardiologii, Nowa Sól
Nowa Sól, 67-100, Poland
"Oddział Kardiologiczno-Internistyczny
Olsztyn, 10-045, Poland
"Oddział Kardiologiczny Publiczny Samodzielny ZOZ Wojewódzkie Centrum Medyczne
Opole, 45-418, Poland
Specjalistyczny Zakład Opieki Zdrowotnej Poradnia lekarzy specjalistów "Jantar"
Ostrów Wielkopolski, 63-400, Poland
ZOZ w Oławie, Oddział Chorób Wewnętrznych
Oława, 55-200, Poland
II Oddział Wewnętrzny Samodzielny Publiczny Zakład Opieki Zdrowotnej
Pabianice, 95-200, Poland
"Samodzielny Szpital Wojewódzki im. Mikołaja Kopernika, Oddział Kardiologiczny
Piotrkow Trybunalski, 97-300, Poland
Medyczne Centrum Hetmańska, Indywiualna Specjalistyczna Praktyka Lekarska, Dr n. med. Piotr Leszczyński
Poznan, 60-218, Poland
Specjalistyczne Centrum Diagnostyczno-Lecznicze Bamberski Dwór
Poznan, 60-539, Poland
Oddział Wewnetrzny I, Szpital Kolejowy im. dr med. Włodzimierza Roeslera
Pruszków, 05-800, Poland
Samodzileny Publiczny Zakład Opieki Zdrowotnej w Puławach, Szpital Specjalistyczny
Puławy, 24-100, Poland
Wojewódzki Szpital Zespolony, Oddział Kardiologiczny
Płock, 09-400, Poland
Specjalistyczna Przychodnia Lekarska "Medikard"
Płock, 09-402, Poland
Zakład Hemodynamiki, Wojewódzki Szpital Specjalistyczny
Radom, 26-617, Poland
"Oddział Kardiologii z Pododdziałem Ostrych Zespołów Wieńcowych i z Ośrodkiem Implantacji Rozruszników Serca,
Rzeszów, 35-301, Poland
Oddział Kardiologii, SP ZZOZ Sandomierz
Sandomierz, 27-600, Poland
Oddział Kardiologiczny Wojewódzki Szpital Specjalistyczy w Siedlcach
Siedlce, 08-110, Poland
Oddział Kardiologii Samodzielny Publiczny Zakład Opieki Zdrowotnej w Sieradzu im. Kardynała Stefana Wyszyńskiego
Sieradz, 98-200, Poland
"Oddział Kardiologii, Wojewódzki Szpital Zespolony w Skierniewicach, "
Skierniewice, 96-100, Poland
NZOZ Przychodnia Zadebie, Przychodnia Kardiologiczna
Skierniewice, 96-100, Poland
"Oddział Kardiologii Inwazyjnej i Angiologii z Pr. Hemodynamiki
Stalowa Wola, 37-450, Poland
Szpital Specjalistyczny Św.Jana, Oddział Kardiologii,
Starogard Gdański, 83-200, Poland
Indywidualna Specjalistyczna Praktyka Lekarska
Szczecin, 71-531, Poland
Poradnia Kardiologiczna
Tarnów, 33-100, Poland
Specjalistyczny Gabinet Lekarski Internistyczno-Kardiologiczny-Cardiology
Tarnów, 33-100, Poland
Niepubliczny Zakład Opieki Zdrowotnej "Nasz Lekarz", Praktyka Grupowa Lekarzy Rodzinnych z Przychodnią Specjalistyczną
Torun, 87 100, Poland
Oddział Kardiologii Wojewódzki Szpital Zespolony
Torun, 87-100, Poland
Oddział Kardiologiczny Szpital Wolski im. dr Anny Gostyńskiej Samodzielny Publiczny Zakład Opieki Zdrowotnej
Warsaw, 01 - 211, Poland
Samodzielny Publiczny Centralny Szpital Kliniczny Akademii Medycznej w Warszawie
Warsaw, 02-097, Poland
II Klinika Choroby Wieńcowej Instytutu Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego
Warsaw, 02-637, Poland
Centrum Leczenia Chorób Cywilizacyjnych
Warsaw, 02-777, Poland
Międzyleski Szpital Specjalistyczny w Warszawie
Warsaw, 04-749, Poland
NZOZ Starówka
Warsaw, Poland
"Oddział Kardiologiczny Wałbrzyski Ośrodek Kardiologii Interwencyjnej Specjalityczny Szpital im. Dr Alfreda Sokołowskiego
Wałbrzych, 58-309, Poland
Synexus SCM Sp.z o o.
Wroclaw, 50-088, Poland
Niepubliczny Zakład Opieki Zdrowotnej, Centrum Badań Klinicznych
Wroclaw, 50-349, Poland
Osrodek Chorob Serca, Klinika Kardiologii 4 Wojskowy Szpital Kliniczny z Poliklinika - Samodzielny Publiczny Zaklad Opieki Zdrowotnej
Wroclaw, 50-981, Poland
"Śląskie Centrum Chorób Serca, III Katedra i Oddział Kliniczny Kardiologii Śląskiego Uniwersytetu Medycznego
Zabrze, 41-800, Poland
Oddział Kardiologiczny Szpital Wojewódzki im. Kardynała Stefana Wyszyńskiego
Łomża, 18-404, Poland
Research and Cardiovascular Corp.
Ponce, 00717-1322, Puerto Rico
Spitalul Clinic Judetean de Urgenta Bacau
Bacau, 600114, Romania
S.C. Duo Medical S.R.L.
Bucharest, 010584, Romania
Centrul Medical SANA
Bucharest, 011025, Romania
Cardiomed SRL
Bucharest, 020506, Romania
Institutul Inimii "Niculae Stanicioiu"
Cluj-Napoca, 400001, Romania
Cardiomed SRL
Craiova, 200147, Romania
Dr. C.I. Parhon Hospital
Iași, 700503, Romania
Clinical county Hospital
Sibiu, 550245, Romania
Institutul de Boli Cardiovasculare si Transplan Tg. Mures
Târgu Mureş, 540136, Romania
County Hospital
Timișoara, 300736, Romania
Novamed s.r.o.
Banská Bystrica, 97405, Slovakia
Alian s.r.o.
Bardejov, 085-01, Slovakia
5. Interna klinika LF UK, FNsP Bratislava, Nemocnica Ruzinov
Bratislava, 826 06, Slovakia
Cardio D&R spol. s r.o.
Košice, 040-22, Slovakia
Kardiomed s.r.o.
Lučenec, 98401, Slovakia
NZZ Kardiocentrum Nitra s.r.o.
Nitra, 950-01, Slovakia
MUDr. Tibor DURIS, CSc., s.r.o.
Nové Zámky, 94052, Slovakia
Nemocnica s poliklinikou Považská Bystrica
Považská Bystrica, 017 26, Slovakia
Fakultna Nemocnica Trencin
Trenčín, 911 71, Slovakia
Žilpo s.r.o.
Žilina, 010 01, Slovakia
Medivasa s.r.o.
Žilina, 010-01, Slovakia
"Klinichne obyednannia shvydkoi medychnoi dopomogy, m. Dnipropetrovs'k,Dnipropetrovs'ka derzhavna medychna akademiya, kafedra gospital'noi terapii #2
Dnipropetrovsk, 49006, Ukraine
Oblasnyi klinichnyi kardiologichnyi dyspanser, m. Ivano-Frankivsk, Ivano-Frankivskyi derzhavnyi medychnyi universytet, kafedra terapii # 3
Ivano-Frankivsk, 76005, Ukraine
TOV "Kardiologichna klinika "Sertse i sudyny" m. Kyiv
Kyiv, 1032, Ukraine
Natsionalnyi naukovyi tsentr "Instytut kardiologii im. akad. M.D. Strazheska" AMN Ukrainy, m. Kyiv, viddilenia symptomatychnykh arterial'nykh gipertenziy
Kyiv, 3680, Ukraine
Natsionalnyi naukovyi tsentr "Instytut kardiologii im. akad. M.D. Strazheska", viddil reanimatsii ta intensyvnoi terapii, m. Kyiv
Kyiv, 3680, Ukraine
Komunal'na ustanova "Oblasnyi kardiologichnyi dyspanser", viddilenia intensyvnoi terapii, m. Zaporizhzhia
Zaporizhzhya, 69000, Ukraine
Kardioarytmologichnyi tsentr Zhytomyrs'koi oblasnoi klinichnoi likarni im. O.F. Gorbachevs'kogo, m. Zhytomyr
Zhytomyr, 10002, Ukraine
Related Publications (2)
Vaduganathan M, Bhatt DL, Cryer BL, Liu Y, Hsieh WH, Doros G, Cohen M, Lanas A, Schnitzer TJ, Shook TL, Lapuerta P, Goldsmith MA, Laine L, Cannon CP; COGENT Investigators. Proton-Pump Inhibitors Reduce Gastrointestinal Events Regardless of Aspirin Dose in Patients Requiring Dual Antiplatelet Therapy. J Am Coll Cardiol. 2016 Apr 12;67(14):1661-71. doi: 10.1016/j.jacc.2015.12.068. Epub 2016 Mar 21.
PMID: 27012778DERIVEDBhatt DL, Cryer BL, Contant CF, Cohen M, Lanas A, Schnitzer TJ, Shook TL, Lapuerta P, Goldsmith MA, Laine L, Scirica BM, Murphy SA, Cannon CP; COGENT Investigators. Clopidogrel with or without omeprazole in coronary artery disease. N Engl J Med. 2010 Nov 11;363(20):1909-17. doi: 10.1056/NEJMoa1007964. Epub 2010 Oct 6.
PMID: 20925534DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Pablo Lapuerta, MD
Cogentus Pharmaceuticals
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
Study Record Dates
First Submitted
November 12, 2007
First Posted
November 14, 2007
Study Start
December 1, 2007
Primary Completion
November 1, 2009
Study Completion
November 1, 2009
Last Updated
January 28, 2009
Record last verified: 2009-01