NCT00541762|Completed
Regulation of Fat-stimulated Neurotensin Secretion in Healthy Subjects
Mechanistic Study (Physiology)
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Mechanistic Study (Physiology)
Sponsor study identifier
Secondary identifiers
interventional
34
1 country
1
Study Start
January 2006
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
March 2007
Actual (reported)Study Completion
March 2007
Actual (reported)Context: Cholecystokinin (CCK) and neurotensin are stimulated during meal intake by the presence of fat in the small intestine. The sequence of events suggests that fat hydrolysis is crucial for triggering the release. Objectives: The aim of this study was therefore to investigate whether CCK mediated the effect of intraduodenal (ID) fat on neurotensin secretion via CCK-1 receptors.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 2007
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 2006
Date type not reportedThis date has not been verified as actual or estimated.
March 2007
Actual (reported)March 2007
Actual (reported)October 8, 2007
Actual (reported)October 10, 2007
Actual (reported)Neurotensin plasma concentrations
Change in plasma cocnentrations over 2-3 hours
A, 3: Fat with and without orlistat or placebo. B, 3: LCF vs MCF vs placebo. C, 3: LCF with and without DEXLOX or placebo.
1. Triglycerides, long chain fatty acids, medium chain fatty acids perfused to the small intestine 2. Orlistat perfused to the small intestine 3. DEXLOX as CCK-1 receptor antagonist
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Clinical Research Center, University Hospital
Basel, CH-4031, Switzerland
Ferris CF, Carraway RE, Hammer RA, Leeman SE. Release and degradation of neurotensin during perfusion of rat small intestine with lipid. Regul Pept. 1985 Oct;12(2):101-11. doi: 10.1016/0167-0115(85)90191-0.
Juergen Drewe, MD
University Hospital, 4031 Basel, Switzerland
Christoph Beglinger, MD
Department of Research and Clinical Pharmacology, University Hospital, Basel Switzerland
34 participants (actual enrollment reported by the registry).
First Submitted
October 8, 2007
First Posted
October 10, 2007
Study Start
January 2006
Date type not reportedThis date has not been verified as actual or estimated.
Effects of Dietary Fructose on Glucose and Lipid Metabolism in Healthy Human Subjects
Primary Completion
March 2007
Actual (reported)Study Completion
March 2007
Actual (reported)Last Updated
March 10, 2015
Record last verified: 2015-03
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Source: ClinicalTrials.gov.
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