A Long-Term Examination of Asthma From Childhood Through Adolescence

NCT00541255 | Completed

• 3 other identifiers: 1408R01HL0829251R01HL082925-01A2
• Study Type: observational
• Target: 1,313
• Locations: 1 country
• Sites: 1

Brief Summary

Asthma is a common disease that is often diagnosed in childhood. In some teenagers, asthma symptoms disappear and treatment can be stopped; however, for some of these people, asthma symptoms return in adulthood. This study will examine data collected over the lifetime of 18-year olds to identify factors that may increase a person's chance of having recurrent asthma as an adult.

Conditions

Asthma; Dermatitis, Atopic; Rhinitis; Urticaria

Keywords

Bronchial Asthma; Food Allergy; Bronchial Hyperresponsiveness

Outcome Measures

Primary Outcomes (1)

• Identifying factors that may increase a person's chance of having recurrent asthma as an adult

  Measured throughout the participant's lifetime

Eligibility Criteria

• Age: 17 Years - 19 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of around 1500 unselected subjects (now age 18) who were recruited at birth. This is a homogenous population with 99% being Caucasians.

You may qualify if:

• Born on the Isle of Wight in the United Kingdom between January 1, 1989 and February 28, 1990

You may not qualify if:

• Refused consent

Sponsors & Collaborators

• Isle of Wight NHS Trust: lead
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Study Sites (1)

The David Hide Asthma and Allergy Research Centre

Newport, Isle Of Wight, PO305TG, United Kingdom

Location

Related Links

• Click here for The David Hide Asthma and Allergy Research Centre Web site

Biospecimen

Retention: SAMPLES WITH DNA

Whole blood, serum, saliva, urine

MeSH Terms

Conditions

Asthma; Dermatitis, Atopic; Rhinitis; Urticaria; Food Hypersensitivity; Bronchial Hyperreactivity

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases; Skin Diseases, Genetic; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Dermatitis; Skin Diseases; Skin and Connective Tissue Diseases; Skin Diseases, Eczematous; Respiratory Tract Infections; Infections; Nose Diseases; Otorhinolaryngologic Diseases; Skin Diseases, Vascular

Study Officials

• Syed Arshad, MD

  University of Southampton, United Kingdom

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chair in Allergy and Clinical Immunology, University of Southampton and Hon. Consultant Physician, University Hospital Southampton Director, The David Hide Asthma and Allergy Research Centre

Study Record Dates

• First Submitted: October 9, 2007
• First Posted: October 10, 2007
• Study Start: September 1, 2007
• Primary Completion: May 1, 2012
• Study Completion: February 18, 2015
• Last Updated: March 1, 2023

Record last verified: 2023-02

Locations

GB (1)