MACRONUTR
Study of the Role of Insulin Resistance in the Pathogenesis of the Metabolic Syndrome and of Non-alcoholic Steatohepatitis
Sponsor study identifier
interventional
41
1 country
1
Study Start
July 2006
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
April 2008
Actual (reported)Study Completion
January 2009
Actual (reported)The purpose of this study is to assess how the macronutrient composition of the diet effects
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 2009
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
July 2006
Date type not reportedThis date has not been verified as actual or estimated.
August 30, 2007
Actual (reported)August 31, 2007
Actual (reported)April 2008
Actual (reported)January 2009
Actual (reported)plasma triglycerides
6 days
intra-hepatic lipids
6 days
insulin mediated glucose disposal
6 days
lipid oxidation
6 days
Effects of diet intervention " high fructose" in normal weight subjects
Effect of diet intervention "high fructose" in healthy non-obese offsprings of patients with type 2 diabetes
effects of diet intervention "high fat" in healthy male subjects
controlled hypercaloric high fructose, high fat, or high fat/high protein diet
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Centre Hospitalier Universitaire Vaudois
Lausanne, CH-1011, Switzerland
Bortolotti M, Kreis R, Debard C, Cariou B, Faeh D, Chetiveaux M, Ith M, Vermathen P, Stefanoni N, Le KA, Schneiter P, Krempf M, Vidal H, Boesch C, Tappy L. High protein intake reduces intrahepatocellular lipid deposition in humans. Am J Clin Nutr. 2009 Oct;90(4):1002-10. doi: 10.3945/ajcn.2008.27296. Epub 2009 Aug 26.
Le KA, Ith M, Kreis R, Faeh D, Bortolotti M, Tran C, Boesch C, Tappy L. Fructose overconsumption causes dyslipidemia and ectopic lipid deposition in healthy subjects with and without a family history of type 2 diabetes. Am J Clin Nutr. 2009 Jun;89(6):1760-5. doi: 10.3945/ajcn.2008.27336. Epub 2009 Apr 29.
Luc Tappy, MD
University of Lausanne
41 participants (actual enrollment reported by the registry).
First Submitted
August 30, 2007
First Posted
August 31, 2007
Study Start
July 2006
Date type not reportedThis date has not been verified as actual or estimated.
plasma beta-hydroxybutyrate
6 days
gene expression in skeletal muscle and adipose tissue
6 days
effect of diet intervention "high fat + protein" subjects in healthy male subjects
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Primary Completion
April 2008
Actual (reported)Study Completion
January 2009
Actual (reported)Last Updated
June 14, 2018
Record last verified: 2018-06
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Source: ClinicalTrials.gov.
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