Effects of an Amino-acid Supplement on Hepatic Lipid Metabolism
AMINOFRUCT
Effects of a Supplementation With Amino-acids on Hepatic Lipid Metabolism
1 other identifier
interventional
9
1 country
1
Brief Summary
10 healthy male volunteers will be studied after
- a 6 day weight maintenance, balanced diet
- a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body weight/day
- a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body weight/day and 20g amino-acids per day At the end of each 6 days period, the following measurements will be obtained
- intrahepatic lipids (1H-MRS)
- metabolic effects of fructose ingestion (measurement of substrate oxidation, gluconeogenesis from fructose, palmitate synthesis from fructose, plasma VLDL-kinetics) This is a randomized, double blinded study
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started May 2010
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2010
CompletedFirst Submitted
Initial submission to the registry
May 6, 2010
CompletedFirst Posted
Study publicly available on registry
May 10, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2011
CompletedMay 4, 2018
May 1, 2018
10 months
May 6, 2010
May 1, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
intrahepatic lipids
after 6 days on each controlled diet
Secondary Outcomes (1)
13C palmitate synthesis
after 6 days on each controlled diet
Study Arms (3)
weight maintenance diet
NO INTERVENTIONweight maintenance + fructose
PLACEBO COMPARATORweight maintenance diet + fructose and amino-acid
EXPERIMENTALInterventions
Eligibility Criteria
You may qualify if:
- age 18-30 years
- sex: males
- BMI between 19 and 25 kg/m2
- less than 3 30min- exercise session/week
You may not qualify if:
- smokers
- alcohol consumption more than 50g/week
- consumption of drugs
- history of diabetes in first degree relatives
- presence of ferro-magnetic prosthesis, cardiac pacemakers, or any contra-indication to NMR
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Lausannelead
- University of Berncollaborator
Study Sites (1)
Centre Hospitalier Universitaire Vaudois
Lausanne, Canton of Vaud, CH-1011, Switzerland
Related Publications (1)
Theytaz F, Noguchi Y, Egli L, Campos V, Buehler T, Hodson L, Patterson BW, Nishikata N, Kreis R, Mittendorfer B, Fielding B, Boesch C, Tappy L. Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans. Am J Clin Nutr. 2012 Nov;96(5):1008-16. doi: 10.3945/ajcn.112.035139. Epub 2012 Oct 3.
PMID: 23034968DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor of Physiology
Study Record Dates
First Submitted
May 6, 2010
First Posted
May 10, 2010
Study Start
May 1, 2010
Primary Completion
March 1, 2011
Study Completion
December 1, 2011
Last Updated
May 4, 2018
Record last verified: 2018-05