NCT00483015

Brief Summary

We wish to discover if there is a difference in the presentation, response to treatment and survival of never- smokers with lung cancer as compared to ever- smokers. We also plan to obtain tumor specimens to compare the genetic and proteomic expression between smokers and never smokers

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
280

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Mar 2006

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2006

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2007

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2007

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

June 4, 2007

Completed
2 days until next milestone

First Posted

Study publicly available on registry

June 6, 2007

Completed
Last Updated

August 13, 2013

Status Verified

August 1, 2013

Enrollment Period

1.1 years

First QC Date

June 4, 2007

Last Update Submit

August 9, 2013

Conditions

Smokers

Keywords

presentationoutcomeresponsenever- smokers

Interventions

smokingBEHAVIORAL

Eligibility Criteria

Age18 Years - 88 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Study Population

Age Range 18-88, diagnosed with non- small cell lung cancer between Jan 1 1996 and Dec 31 2002.

You may qualify if:

  • Age Range 18-88, diagnosed with non- small cell lung cancer between Jan 1 1996 and Dec 31 2002.

You may not qualify if:

  • Patients diagnosed prior to Dec 31, 1995 and after Jan 1, 2003

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (6)

  • Tammemagi CM, Neslund-Dudas C, Simoff M, Kvale P. Impact of comorbidity on lung cancer survival. Int J Cancer. 2003 Mar 1;103(6):792-802. doi: 10.1002/ijc.10882.

    PMID: 12516101BACKGROUND

  • Sanchez-Cespedes M, Ahrendt SA, Piantadosi S, Rosell R, Monzo M, Wu L, Westra WH, Yang SC, Jen J, Sidransky D. Chromosomal alterations in lung adenocarcinoma from smokers and nonsmokers. Cancer Res. 2001 Feb 15;61(4):1309-13.

    PMID: 11245426BACKGROUND

  • Vahakangas KH, Bennett WP, Castren K, Welsh JA, Khan MA, Blomeke B, Alavanja MC, Harris CC. p53 and K-ras mutations in lung cancers from former and never-smoking women. Cancer Res. 2001 Jun 1;61(11):4350-6.

    PMID: 11389059BACKGROUND

  • Gazdar AF. Lung cancer in never smokers - A different pathway. ASCO 2005:619-21

    BACKGROUND

  • Jemal A, Tiwari RC, Murray T, Ghafoor A, Samuels A, Ward E, Feuer EJ, Thun MJ; American Cancer Society. Cancer statistics, 2004. CA Cancer J Clin. 2004 Jan-Feb;54(1):8-29. doi: 10.3322/canjclin.54.1.8.

    PMID: 14974761RESULT

  • Nordquist LT, Simon GR, Cantor A, Alberts WM, Bepler G. Improved survival in never-smokers vs current smokers with primary adenocarcinoma of the lung. Chest. 2004 Aug;126(2):347-51. doi: 10.1378/chest.126.2.347.

    PMID: 15302716RESULT

Related Links

MeSH Terms

Interventions

Smoking Devices

Intervention Hierarchy (Ancestors)

Manufactured MaterialsTechnology, Industry, and Agriculture

Study Officials

  • Ramaswamy Govindan, M.D.

    Washington University School of Medicine

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 4, 2007

First Posted

June 6, 2007

Study Start

March 1, 2006

Primary Completion

April 1, 2007

Study Completion

April 1, 2007

Last Updated

August 13, 2013

Record last verified: 2013-08