Effects of Chromium Picolinate on Food Intake

NCT00477854 | Completed

• 1 other identifier: PBRC 24040
• Study Type: interventional
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to test the effects of chromium picolinate on food intake, food cravings, eating attitudes, and appetite. If chromium picolinate is found to have a beneficial impact on satiety and food intake, then this supplement may be an alternative or adjunctive treatment for overweight people desiring to modify their food intake. The primary hypothesis of this study is that among individuals who report being carbohydrate cravers, chromium picolinate supplementation will reduce food intake during a test lunch meal and produce greater satiety in comparison to a placebo.

Conditions

Obesity; Atypical Depression

Outcome Measures

Primary Outcomes (1)

• Food intake at both a test lunch meal and at a test dinner meal presented 4.5 hours later

  8 weeks

Secondary Outcomes (1)

• Hunger and satiety between the lunch and dinner meal

  8 weeks

Study Arms (2)

Visual Analogue Scale Ratings

EXPERIMENTAL

Food intake data and its coefficients, including total food intake, food not eaten, duration of the meal, and bite rate. A mixed model analysis of variance will also be conducted on ratings of food cravings and eating atttudes. Changes in hunger and satiety ratings between, before, and after the meals will be compared for difference across treatment conditions.

Drug: Chromium Picolinate

Consuming less Lunch allows consumption of more dinner

EXPERIMENTAL

Test whether chromium picolinate supplementation affects food cravings, eating attitudes, and satiety in healthy, overweight and/or obese, adult women who are determinded to be carbohydrate cravers. Whether participants who eat less at a lunch test meal consume more food at an ad lib dinner test meal with a diversity of foods.

Drug: Chromium Picolinate

Interventions

Chromium Picolinate DRUG

Test whether Chromium Picolinate supplementation affects food intake at both a test lunch meal and at a test dinner meal presented 4.5 hours later among healthy, overweight and/or obese, adult women who are determined to be carbohydrate creavers.

Consuming less Lunch allows consumption of more dinner; Visual Analogue Scale Ratings

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy female who has not been diagnosed with diabetes, cardiovascular illness, or other chronic diseases,
• Food craver, determined by self-reported craving for carbohydrates on two out of three validated measures of food cravings,
• \> 18 years of age and \< 50 years of age, and
• Body mass index between 25 and 39.9 kg/m2. Participants will be scheduled for testing during the luteal phase of their menstrual cycle to limit the confounding effect of the menstrual cycle on energy intake. We will include women who are taking monophasic oral contraceptives but will exclude other oral contraceptive regimens. Participants with very irregular menstrual cycles will also be excluded because this irregularity will make it very difficult to schedule testing during the luteal phase of the menstrual cycle.

You may not qualify if:

• Potential participants will be excluded for the following reasons:
• Participants who report smoking cigarettes will be excluded because of the effects of nicotine upon taste and appetite,
• Participants who have a diagnosable eating disorder (i.e., anorexia or bulimia nervosa) will also be excluded since intentional restriction of eating and binge eating/overeating could increase the variability of the data,
• Participants who report using diet pills will be excluded since diet pills may potentially influence appetite, hunger, and/or satiety,
• Participants will be excluded if they are taking anti-depressant medications, anti-psychotic medications, or any medications that may potentially influence appetite, hunger, and/or satiety,
• Participants who are not determined to be carbohydrate cravers will be excluded,
• Participants will also be excluded if they report any allergies to the foods that will be used in the study.

Sponsors & Collaborators

• Pennington Biomedical Research Center: lead
• Nutrition 21, Inc.: collaborator

Study Sites (1)

Pennington Biomedical Research Center

Baton Rouge, Louisiana, 70808, United States

Location

MeSH Terms

Conditions

Obesity

Interventions

picolinic acid

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Stephen D Anton, Ph.D.

  Pennington Biomedical Research Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 23, 2007
• First Posted: May 24, 2007
• Study Start: April 1, 2005
• Primary Completion: May 1, 2007
• Study Completion: May 1, 2007
• Last Updated: February 12, 2016

Record last verified: 2016-02

Locations

US (1)