Cognitive Impairment in Parkinson's Disease Categorised in Accordance to Motor Symptoms

NCT00476372 | Completed

• 1 other identifier: UAarhus
• Study Type: observational
• Target: 107
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Approximately 40% of patients with Parkinson's disease (PD) have cognitive impairments. There is a lack of consensus as to the extent to which psychiatric symptoms, depression, age at disease onset, disease duration, and medication is related to the type and severity of cognitive impairment. This discrepancy can in part be caused by the lack of distinction between patients with different motor symptoms and disease severity. Objective: To identify the extent to which psychiatric symptoms, depression, age at disease onset, disease duration, and medication is related to the severity and type of cognitive dysfunction in patients with idiopathic PD categorized according to motor symptoms and disease severity. Methods: the population of patients with PD in the old county of Aarhus is described on the background of medical records, and stratified in accordance to age, sex and cardinal symptoms. Through proportional allocation a sample of a minimum of 50 patients with PD is drawn from the population. The patients and 30 healthy matched controls will undergo comprehensive neuropsychological assessment including tests of language, memory, executive function, and visuospatial function. Furthermore, all participants will be screened for depression (Geriatric Depression Scale) and psychiatric symptoms (Neuropsychiatric Inventory and Symptom Checklist). The patients will be categorized in accordance with their motor symptoms via cluster analysis for the purpose of analyzing the effect of psychiatric symptoms, depression, and age of disease onset, disease duration, and medication on cognition.

Conditions

Parkinson's Disease

Keywords

neuropsychology; cognitive impairment; motor disorder; parkinson's disease

Outcome Measures

Primary Outcomes (1)

• cognitive measures

  1 hour

Study Arms (1)

Parkinson's disease

Pt with parkinsons disease

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

77 patients with PD and 30 healthy control participants

You may qualify if:

• Idiopathic Parkinson's in accordance to UK Parkinson's Disease Society Brain Bank Clinical Diagnostic Criteria,
• Born and raised in Denmark ,
• \>50 years

You may not qualify if:

• Cerebrovascular disease,
• Dementia not caused by Parkinson's Disease,
• Metabolism anomaly,
• Abuse of drugs, medication or alcohol,
• History of head injuries,
• Severe psychiatric disorder, excluding depression,
• Resident outside the region of Aarhus h) DBS -

Sponsors & Collaborators

• University of Aarhus: lead

Study Sites (1)

Aarhus Universitetshospital

Aarhus, 8000, Denmark

Location

MeSH Terms

Conditions

Parkinson Disease; Cognitive Dysfunction; Motor Disorders

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Karen Østergaard, neurologist

  Aarhus University Hospital

  STUDY CHAIR

• Lars Larsen, MSc, PhD, Associate Professor

  The Institute of Psychology

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 21, 2007
• First Posted: May 22, 2007
• Study Start: August 1, 2007
• Primary Completion: December 1, 2011
• Study Completion: December 1, 2011
• Last Updated: January 14, 2013

Record last verified: 2013-01

Locations

DK (1)