A Study Testing the Effectiveness of Nesiritide in Patients With Acute Decompensated Heart Failure
Double-Blind, Placebo-Controlled, Multicenter Acute Study of Clinical Effectiveness of Nesiritide in Subjects With Decompensated Heart Failure (ASCEND-HF)
4 other identifiers
interventional
7,141
28 countries
328
Brief Summary
The purpose of this study is to find out if nesiritide (a human B-type natriuretic peptide/hBNP) as compared to placebo, plus the usual treatment for acute decompensated heart failure, helps to improve breathing difficulties, reduce heart failure readmissions to hospitals, and helps patients live longer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started May 2007
Typical duration for phase_3
328 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2007
CompletedFirst Submitted
Initial submission to the registry
May 18, 2007
CompletedFirst Posted
Study publicly available on registry
May 21, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2011
CompletedResults Posted
Study results publicly available
May 10, 2012
CompletedMarch 8, 2013
March 1, 2013
3.8 years
May 18, 2007
September 27, 2011
March 1, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Composite of Rehospitalization Due to Heart Failure and All-Cause Mortality
Randomization to Day 30
Dyspnea Self-Assessment at 6 Hours After Initiation of Study Drug
Dyspnea symptoms were measured by patient self-assessed Likert scale at 6 hours after study drug initiation.The Likert scale is a 7-point ordinal categorical scale (the 7 categories are markedly better, moderately better, minimally better, unchanged, minimally worse, moderately worse, and markedly worse.)
6 hours after initiation of study drug
Dyspnea Self-Assessment at 24 Hours After Initiation of Study Drug
Dyspnea symptoms were measured by patient self-assessed Likert scale at 24 hours after study drug initiation. The Likert scale is a 7-point ordinal categorical scale (the 7 categories are markedly better, moderately better, minimally better, unchanged, minimally worse, moderately worse, and markedly worse.)
24 hours after study drug initiation
Secondary Outcomes (5)
Overall Well-Being Self-Assessment at 6 Hours After Initiation of Study Drug
6 hours after study drug initiation
Overall Well-Being Self-Assessment at 24 Hours After Initiation of Study Drug
24 hours after study drug initiation
Composite of Persistent or Worsening Heart Failure and All-Cause Mortality
Randomization to hospital discharge (up to Day 30)
Number of Days Alive and Outside the Hospital
Randomization to Day 30
Composite of Cardiovascular Rehospitalization and Cardiovascular Mortality
Randomization to Day 30
Other Outcomes (4)
All-Cause Mortality Through Day 30
Randomization to Day 30
All-Cause Mortality Through Day 180
Randomization to Day 180
Cardiovascular Mortality Through Day 30
Randomization to Day 30
- +1 more other outcomes
Study Arms (2)
001
EXPERIMENTALNesiritide 0.01 mcg/kg/min intravenous (IV) infusion (with or without 2 mcg/kg bolus) for 24 to 168 hours (hrs)
002
PLACEBO COMPARATORPlacebo matching placebo infusion:0.01 mcg/kg/min IV infusion (with or without 2 mcg/kg bolus) for 24 to 168 hrs
Interventions
matching placebo infusion:0.01 mcg/kg/min IV infusion (with or without 2 mcg/kg bolus) for 24 to 168 hrs
Eligibility Criteria
You may qualify if:
- Hospitalized for the management of acute decompensated heart failure (ADHF) or diagnosed with ADHF within 48 hours after being hospitalized for another reason; Diagnosis of ADHF is defined as dyspnea (difficulty breathing) at rest or dyspnea with minimal activity.
You may not qualify if:
- At high risk for hypotension (low blood pressure); Acute coronary syndrome as primary diagnosis; History of cardiac valvular stenosis, restrictive cardiomyopathy, hypertrophic cardiomyopathy, or pericardial tamponade; Previous enrollment in a nesiritide study; Persistent, uncontrolled hypertension (SBP \[systolic blood pressure\] \>180 mmHg).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Scios, Inc.lead
Study Sites (328)
Unknown Facility
Huntsville, Alabama, United States
Unknown Facility
Mobile, Alabama, United States
Unknown Facility
Anchorage, Alaska, United States
Unknown Facility
Gilbert, Arizona, United States
Unknown Facility
Scottsdale, Arizona, United States
Unknown Facility
Fort Smith, Arkansas, United States
Unknown Facility
Jonesboro, Arkansas, United States
Unknown Facility
Berkeley, California, United States
Unknown Facility
Culver City, California, United States
Unknown Facility
Escondido, California, United States
Unknown Facility
Inglewood, California, United States
Unknown Facility
Loma Linda, California, United States
Unknown Facility
Los Angeles, California, United States
Unknown Facility
Mission Viejo, California, United States
Unknown Facility
Sacramento, California, United States
Unknown Facility
San Diego, California, United States
Unknown Facility
Santa Ana, California, United States
Unknown Facility
Torrance, California, United States
Unknown Facility
Ventura, California, United States
Unknown Facility
Denver, Colorado, United States
Unknown Facility
Englewood, Colorado, United States
Unknown Facility
Fort Collins, Colorado, United States
Unknown Facility
Hartford, Connecticut, United States
Unknown Facility
New Haven, Connecticut, United States
Unknown Facility
Newark, Delaware, United States
Unknown Facility
Washington D.C., District of Columbia, United States
Unknown Facility
Clearwater, Florida, United States
Unknown Facility
Fort Lauderdale, Florida, United States
Unknown Facility
Gainesville, Florida, United States
Unknown Facility
Inverness, Florida, United States
Unknown Facility
Lakeland, Florida, United States
Unknown Facility
Melbourne, Florida, United States
Unknown Facility
Miami Beach, Florida, United States
Unknown Facility
Ocala, Florida, United States
Unknown Facility
Orlando, Florida, United States
Unknown Facility
Tallahassee, Florida, United States
Unknown Facility
Tampa, Florida, United States
Unknown Facility
Winter Haven, Florida, United States
Unknown Facility
Atlanta, Georgia, United States
Unknown Facility
Augusta, Georgia, United States
Unknown Facility
Gainesville, Georgia, United States
Unknown Facility
Macon, Georgia, United States
Unknown Facility
Aurora, Illinois, United States
Unknown Facility
Chicago, Illinois, United States
Unknown Facility
Downers Grove, Illinois, United States
Unknown Facility
Elk Grove Village, Illinois, United States
Unknown Facility
Hinsdale, Illinois, United States
Unknown Facility
La Grange, Illinois, United States
Unknown Facility
Maywood, Illinois, United States
Unknown Facility
Mokena, Illinois, United States
Unknown Facility
Oakbrook Terrace, Illinois, United States
Unknown Facility
Peoria, Illinois, United States
Unknown Facility
Rockford, Illinois, United States
Unknown Facility
Springfield, Illinois, United States
Unknown Facility
Anderson, Indiana, United States
Unknown Facility
Indianapolis, Indiana, United States
Unknown Facility
Munster, Indiana, United States
Unknown Facility
South Bend, Indiana, United States
Unknown Facility
Valparaiso, Indiana, United States
Unknown Facility
Danville, Kentucky, United States
Unknown Facility
Edgewood, Kentucky, United States
Unknown Facility
Lexington, Kentucky, United States
Unknown Facility
Owensboro, Kentucky, United States
Unknown Facility
Baltimore, Maryland, United States
Unknown Facility
Randallstown, Maryland, United States
Unknown Facility
Rockville, Maryland, United States
Unknown Facility
Boston, Massachusetts, United States
Unknown Facility
Brighton, Massachusetts, United States
Unknown Facility
Springfield, Massachusetts, United States
Unknown Facility
Worcester, Massachusetts, United States
Unknown Facility
Bay City, Michigan, United States
Unknown Facility
Detroit, Michigan, United States
Unknown Facility
Flint, Michigan, United States
Unknown Facility
Lansing, Michigan, United States
Unknown Facility
Monroe, Michigan, United States
Unknown Facility
Petoskey, Michigan, United States
Unknown Facility
Pontiac, Michigan, United States
Unknown Facility
Saginaw, Michigan, United States
Unknown Facility
Troy, Michigan, United States
Unknown Facility
Minneapolis, Minnesota, United States
Unknown Facility
Tupelo, Mississippi, United States
Unknown Facility
Kansas City, Missouri, United States
Unknown Facility
Springfield, Missouri, United States
Unknown Facility
St Louis, Missouri, United States
Unknown Facility
Lincoln, Nebraska, United States
Unknown Facility
Omaha, Nebraska, United States
Unknown Facility
Papillion, Nebraska, United States
Unknown Facility
Manchester, New Hampshire, United States
Unknown Facility
Browns Mills, New Jersey, United States
Unknown Facility
Camden, New Jersey, United States
Unknown Facility
Elmer, New Jersey, United States
Unknown Facility
Hackensack, New Jersey, United States
Unknown Facility
Neptune City, New Jersey, United States
Unknown Facility
Newark, New Jersey, United States
Unknown Facility
Paterson, New Jersey, United States
Unknown Facility
Ridgewood, New Jersey, United States
Unknown Facility
Toms River, New Jersey, United States
Unknown Facility
Trenton, New Jersey, United States
Unknown Facility
Turnersville, New Jersey, United States
Unknown Facility
Albany, New York, United States
Unknown Facility
Brooklyn, New York, United States
Unknown Facility
Elmhurst, New York, United States
Unknown Facility
Johnson City, New York, United States
Unknown Facility
New Hyde Parke, New York, United States
Unknown Facility
Poughkeepsie, New York, United States
Unknown Facility
Rochester, New York, United States
Unknown Facility
Roslyn, New York, United States
Unknown Facility
Saratoga Springs, New York, United States
Unknown Facility
Stony Brook, New York, United States
Unknown Facility
The Bronx, New York, United States
Unknown Facility
Valhalla, New York, United States
Unknown Facility
Asheville, North Carolina, United States
Unknown Facility
Chapel Hill, North Carolina, United States
Unknown Facility
Charlotte, North Carolina, United States
Unknown Facility
Durham, North Carolina, United States
Unknown Facility
Gastonia, North Carolina, United States
Unknown Facility
Greenville, North Carolina, United States
Unknown Facility
Winston-Salem, North Carolina, United States
Unknown Facility
Akron, Ohio, United States
Unknown Facility
Canton, Ohio, United States
Unknown Facility
Cincinnati, Ohio, United States
Unknown Facility
Cleveland, Ohio, United States
Unknown Facility
Columbus, Ohio, United States
Unknown Facility
Dayton, Ohio, United States
Unknown Facility
Garfield Heights, Ohio, United States
Unknown Facility
Mansfield, Ohio, United States
Unknown Facility
Mayfield Heights, Ohio, United States
Unknown Facility
Middletown, Ohio, United States
Unknown Facility
Sylvania, Ohio, United States
Unknown Facility
Toledo, Ohio, United States
Unknown Facility
Youngstown, Ohio, United States
Unknown Facility
Midwest City, Oklahoma, United States
Unknown Facility
Oklahoma City, Oklahoma, United States
Unknown Facility
Tulsa, Oklahoma, United States
Unknown Facility
Bend, Oregon, United States
Unknown Facility
Abington, Pennsylvania, United States
Unknown Facility
Allentown, Pennsylvania, United States
Unknown Facility
Beaver, Pennsylvania, United States
Unknown Facility
Bethlehem, Pennsylvania, United States
Unknown Facility
Camp Hill, Pennsylvania, United States
Unknown Facility
Danville, Pennsylvania, United States
Unknown Facility
Harrisburg, Pennsylvania, United States
Unknown Facility
Lancaster, Pennsylvania, United States
Unknown Facility
Natrona Heights, Pennsylvania, United States
Unknown Facility
Philadelphia, Pennsylvania, United States
Unknown Facility
Pittsburgh, Pennsylvania, United States
Unknown Facility
York, Pennsylvania, United States
Unknown Facility
Anderson, South Carolina, United States
Unknown Facility
Charleston, South Carolina, United States
Unknown Facility
Greenville, South Carolina, United States
Unknown Facility
Spartanburg, South Carolina, United States
Unknown Facility
Sumter, South Carolina, United States
Unknown Facility
Rapid City, South Dakota, United States
Unknown Facility
Kingsport, Tennessee, United States
Unknown Facility
Memphis, Tennessee, United States
Unknown Facility
Nashville, Tennessee, United States
Unknown Facility
Oak Ridge, Tennessee, United States
Unknown Facility
Amarillo, Texas, United States
Unknown Facility
Dallas, Texas, United States
Unknown Facility
Fort Worth, Texas, United States
Unknown Facility
Houston, Texas, United States
Unknown Facility
Tyler, Texas, United States
Unknown Facility
Falls Church, Virginia, United States
Unknown Facility
Harrisonburg, Virginia, United States
Unknown Facility
Lynchburg, Virginia, United States
Unknown Facility
Norfolk, Virginia, United States
Unknown Facility
Winchester, Virginia, United States
Unknown Facility
Tacoma, Washington, United States
Unknown Facility
Burlington, Wisconsin, United States
Unknown Facility
Madison, Wisconsin, United States
Unknown Facility
Milwaukee, Wisconsin, United States
Unknown Facility
Buenos Aires, Argentina
Unknown Facility
Córdoba, Argentina
Unknown Facility
La Plata, Argentina
Unknown Facility
Mar del Plata, Argentina
Unknown Facility
San Miguel de Tucumán, Argentina
Unknown Facility
Santa Fe, Argentina
Unknown Facility
Bedford, Australia
Unknown Facility
Camperdown, Australia
Unknown Facility
Concord, Australia
Unknown Facility
Darlinghurst, Australia
Unknown Facility
Elizabeth Vale, Australia
Unknown Facility
Fitzroy, Australia
Unknown Facility
Hobart, Australia
Unknown Facility
Kogarah, Australia
Unknown Facility
Launceston, Australia
Unknown Facility
Melbourne, Australia
Unknown Facility
Randwick, Australia
Unknown Facility
Belo Horizonte, Brazil
Unknown Facility
Campinas, Brazil
Unknown Facility
Curitiba, Brazil
Unknown Facility
Fortaleza, Brazil
Unknown Facility
Goiânia, Brazil
Unknown Facility
Porto Alegre, Brazil
Unknown Facility
Recife, Brazil
Unknown Facility
Rio de Janeiro-Rj, Brazil
Unknown Facility
Salvador, Brazil
Unknown Facility
São José do Rio Preto, Brazil
Unknown Facility
São Paulo, Brazil
Unknown Facility
Pleven, Bulgaria
Unknown Facility
Sofia, Bulgaria
Unknown Facility
Varna, Bulgaria
Unknown Facility
Calgary, Alberta, Canada
Unknown Facility
Edmonton, Alberta, Canada
Unknown Facility
Red Deer, Alberta, Canada
Unknown Facility
Campbell River, British Columbia, Canada
Unknown Facility
Kelowna, British Columbia, Canada
Unknown Facility
Maple Ridge, British Columbia, Canada
Unknown Facility
New Westminster, British Columbia, Canada
Unknown Facility
Surrey, British Columbia, Canada
Unknown Facility
Vancouver, British Columbia, Canada
Unknown Facility
Victoria, British Columbia, Canada
Unknown Facility
Lakeland, Manitoba, Canada
Unknown Facility
Winnipeg, Manitoba, Canada
Unknown Facility
Halifax, Nova Scotia, Canada
Unknown Facility
Ajax, Ontario, Canada
Unknown Facility
Brampton, Ontario, Canada
Unknown Facility
Cornwall, Ontario, Canada
Unknown Facility
Hamilton, Ontario, Canada
Unknown Facility
Kitchener, Ontario, Canada
Unknown Facility
Ottawa, Ontario, Canada
Unknown Facility
Scarborough Village, Ontario, Canada
Unknown Facility
Toronto, Ontario, Canada
Unknown Facility
Granby, Quebec, Canada
Unknown Facility
Laval, Quebec, Canada
Unknown Facility
Montreal, Quebec, Canada
Unknown Facility
Saint-Charles-Borromée, Quebec, Canada
Unknown Facility
Sherbrooke, Quebec, Canada
Unknown Facility
Ste-Foy, Quebec, Canada
Unknown Facility
Terrebonne, Quebec, Canada
Unknown Facility
Santiago, Chile
Unknown Facility
Santiago Rm, Chile
Unknown Facility
Temuco, Chile
Unknown Facility
Beijing, China
Unknown Facility
Beijing Prc, China
Unknown Facility
Guangdong Province, China
Unknown Facility
Hangzhou, China
Unknown Facility
Jinan, China
Unknown Facility
Shanghai, China
Unknown Facility
Tianjin, China
Unknown Facility
Xi'an, China
Unknown Facility
Barranquilla, Colombia
Unknown Facility
Bogotá Dc, Colombia
Unknown Facility
Floridablanca, Colombia
Unknown Facility
Colmar, France
Unknown Facility
Paris, France
Unknown Facility
Poitiers, France
Unknown Facility
Pontoise, France
Unknown Facility
Thionville Cedex N/A, France
Unknown Facility
Toulouse, France
Unknown Facility
Valenciennes, France
Unknown Facility
Vandœuvre-lès-Nancy, France
Unknown Facility
Bad Krozingen, Germany
Unknown Facility
Berlin, Germany
Unknown Facility
Brandenburg, Germany
Unknown Facility
Ludwigshafen, Germany
Unknown Facility
Lüdenscheid, Germany
Unknown Facility
Neuruppin, Germany
Unknown Facility
Athens, Greece
Unknown Facility
Larissa, Greece
Unknown Facility
Thessalonikis, Greece
Unknown Facility
Volos, Greece
Unknown Facility
Ahmedabad, India
Unknown Facility
Bengaluru, India
Unknown Facility
Coimbatore, India
Unknown Facility
Hyderabad, India
Unknown Facility
Nagpur, India
Unknown Facility
Pune, India
Unknown Facility
Vadodara, India
Unknown Facility
Hadera, Israel
Unknown Facility
Haifa, Israel
Unknown Facility
Holon, Israel
Unknown Facility
Petah Tikva, Israel
Unknown Facility
Ramat Gan, Israel
Unknown Facility
Safed, Israel
Unknown Facility
Kaunas, Lithuania
Unknown Facility
Vilnius Lt, Lithuania
Unknown Facility
Johor Bahru, Malaysia
Unknown Facility
Kuala Lumpur, Malaysia
Unknown Facility
Aguascalientes, Mexico
Unknown Facility
Guadalajara, Mexico
Unknown Facility
San Luis Potosí City, Mexico
Unknown Facility
Sinaloa, Mexico
Unknown Facility
Zapopan, Mexico
Unknown Facility
Amersfoort, Netherlands
Unknown Facility
Delft, Netherlands
Unknown Facility
Gorinchem, Netherlands
Unknown Facility
Groningen, Netherlands
Unknown Facility
Leeuwarden, Netherlands
Unknown Facility
Sneek, Netherlands
Unknown Facility
Auckland, New Zealand
Unknown Facility
Christchurch, New Zealand
Unknown Facility
Hamilton, New Zealand
Unknown Facility
Hastings, New Zealand
Unknown Facility
Lower Hutt, New Zealand
Unknown Facility
Nelson, New Zealand
Unknown Facility
Stavanger, Norway
Unknown Facility
Trondheim, Norway
Unknown Facility
Tønsberg, Norway
Unknown Facility
Bydgoszcz, Poland
Unknown Facility
Gdynia, Poland
Unknown Facility
Krakow, Poland
Unknown Facility
Ostrowiec Świętokrzyski, Poland
Unknown Facility
Skierniewice, Poland
Unknown Facility
Warsaw, Poland
Unknown Facility
Wroclaw, Poland
Unknown Facility
Kemerovo, Russia
Unknown Facility
Moscow, Russia
Unknown Facility
Tomsk, Russia
Unknown Facility
Tyumen, Russia
Unknown Facility
Yekaterinburg, Russia
Unknown Facility
Singapore, Singapore
Unknown Facility
Chungcheongbuk-Do, South Korea
Unknown Facility
Seoul, South Korea
Unknown Facility
Falun, Sweden
Unknown Facility
Uppsala, Sweden
Unknown Facility
Kaohsiung City, Taiwan
Unknown Facility
Taipei, Taiwan
Unknown Facility
Taoyuan District, Taiwan
Unknown Facility
Bangkok, Thailand
Unknown Facility
Khon Kaen, Thailand
Unknown Facility
Dnipro, Ukraine
Unknown Facility
Donetsk, Ukraine
Unknown Facility
Kharkiv, Ukraine
Unknown Facility
Lviv, Ukraine
Unknown Facility
Mykolayiv, Ukraine
Unknown Facility
Vinnitsa, Ukraine
Unknown Facility
Zaporizhzhya, Ukraine
Related Publications (21)
Gui H, Tang WHW, Francke S, Li J, She R, Bazeley P, Pereira NL, Adams K, Luzum JA, Connolly TM, Hernandez AF, McNaughton CD, Williams LK, Lanfear DE. Common Variants on FGD5 Increase Hazard of Mortality or Rehospitalization in Patients With Heart Failure From the ASCEND-HF Trial. Circ Heart Fail. 2023 Sep;16(9):e010438. doi: 10.1161/CIRCHEARTFAILURE.122.010438. Epub 2023 Jul 26.
PMID: 37725680DERIVEDCosiano MF, Vista A, Sun JL, Alhanti B, Harrington J, Butler J, Starling RC, Mentz RJ, Greene SJ. Comparing New York Heart Association Class and Patient-Reported Outcomes Among Patients Hospitalized for Heart Failure. Circ Heart Fail. 2023 Jan;16(1):e010107. doi: 10.1161/CIRCHEARTFAILURE.122.010107. Epub 2022 Oct 31.
PMID: 36314126DERIVEDBlumer V, Mentz RJ, Sun JL, Butler J, Metra M, Voors AA, Hernandez AF, O'Connor CM, Greene SJ. Prognostic Role of Prior Heart Failure Hospitalization Among Patients Hospitalized for Worsening Chronic Heart Failure. Circ Heart Fail. 2021 Apr;14(4):e007871. doi: 10.1161/CIRCHEARTFAILURE.120.007871. Epub 2021 Mar 29.
PMID: 33775110DERIVEDGreene SJ, DeVore AD, Sheng S, Fonarow GC, Butler J, Califf RM, Hernandez AF, Matsouaka RA, Samman Tahhan A, Thomas KL, Vaduganathan M, Yancy CW, Peterson ED, O'Connor CM, Mentz RJ. Representativeness of a Heart Failure Trial by Race and Sex: Results From ASCEND-HF and GWTG-HF. JACC Heart Fail. 2019 Nov;7(11):980-992. doi: 10.1016/j.jchf.2019.07.011. Epub 2019 Oct 9.
PMID: 31606362DERIVEDGreene SJ, Hernandez AF, Sun JL, Butler J, Armstrong PW, Ezekowitz JA, Zannad F, Ferreira JP, Coles A, Metra M, Voors AA, Califf RM, O'Connor CM, Mentz RJ. Relationship Between Enrolling Country Income Level and Patient Profile, Protocol Completion, and Trial End Points. Circ Cardiovasc Qual Outcomes. 2018 Oct;11(10):e004783. doi: 10.1161/CIRCOUTCOMES.118.004783.
PMID: 30354576DERIVEDVerma AK, Sun JL, Hernandez A, Teerlink JR, Schulte PJ, Ezekowitz J, Voors A, Starling R, Armstrong P, O'Conner CM, Mentz RJ. Rate pressure product and the components of heart rate and systolic blood pressure in hospitalized heart failure patients with preserved ejection fraction: Insights from ASCEND-HF. Clin Cardiol. 2018 Jul;41(7):945-952. doi: 10.1002/clc.22981. Epub 2018 Jul 17.
PMID: 29781109DERIVEDBhatt AS, Cooper LB, Ambrosy AP, Clare RM, Coles A, Joyce E, Krishnamoorthy A, Butler J, Felker GM, Ezekowitz JA, Armstrong PW, Hernandez AF, O'Connor CM, Mentz RJ. Interaction of Body Mass Index on the Association Between N-Terminal-Pro-b-Type Natriuretic Peptide and Morbidity and Mortality in Patients With Acute Heart Failure: Findings From ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure). J Am Heart Assoc. 2018 Feb 3;7(3):e006740. doi: 10.1161/JAHA.117.006740.
PMID: 29431103DERIVEDGreene SJ, Hernandez AF, Dunning A, Ambrosy AP, Armstrong PW, Butler J, Cerbin LP, Coles A, Ezekowitz JA, Metra M, Starling RC, Teerlink JR, Voors AA, O'Connor CM, Mentz RJ. Hospitalization for Recently Diagnosed Versus Worsening Chronic Heart Failure: From the ASCEND-HF Trial. J Am Coll Cardiol. 2017 Jun 27;69(25):3029-3039. doi: 10.1016/j.jacc.2017.04.043.
PMID: 28641792DERIVEDGreene SJ, Hernandez AF, Sun JL, Metra M, Butler J, Ambrosy AP, Ezekowitz JA, Starling RC, Teerlink JR, Schulte PJ, Voors AA, Armstrong PW, O'Connor CM, Mentz RJ. Influence of Clinical Trial Site Enrollment on Patient Characteristics, Protocol Completion, and End Points: Insights From the ASCEND-HF Trial (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure). Circ Heart Fail. 2016 Sep;9(9):e002986. doi: 10.1161/CIRCHEARTFAILURE.116.002986.
PMID: 27623769DERIVEDEzekowitz JA, Podder M, Hernandez AF, Armstrong PW, Starling RC, O'Connor CM, Califf RM. Arrival by ambulance in acute heart failure: insights into the mode of presentation from Acute Studies of Nesiritide in Decompensated Heart Failure (ASCEND-HF). BMJ Open. 2016 Mar 17;6(3):e010201. doi: 10.1136/bmjopen-2015-010201.
PMID: 26988350DERIVEDAbualnaja S, Podder M, Hernandez AF, McMurray JJ, Starling RC, O'Connor CM, Califf RM, Armstrong PW, Ezekowitz JA. Acute Heart Failure and Atrial Fibrillation: Insights From the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF) Trial. J Am Heart Assoc. 2015 Aug 24;4(8):e002092. doi: 10.1161/JAHA.115.002092.
PMID: 26304935DERIVEDPatel PA, Heizer G, O'Connor CM, Schulte PJ, Dickstein K, Ezekowitz JA, Armstrong PW, Hasselblad V, Mills RM, McMurray JJ, Starling RC, Tang WH, Califf RM, Hernandez AF. Hypotension during hospitalization for acute heart failure is independently associated with 30-day mortality: findings from ASCEND-HF. Circ Heart Fail. 2014 Nov;7(6):918-25. doi: 10.1161/CIRCHEARTFAILURE.113.000872. Epub 2014 Oct 3.
PMID: 25281655DERIVEDvan Deursen VM, Hernandez AF, Stebbins A, Hasselblad V, Ezekowitz JA, Califf RM, Gottlieb SS, O'Connor CM, Starling RC, Tang WH, McMurray JJ, Dickstein K, Voors AA. Nesiritide, renal function, and associated outcomes during hospitalization for acute decompensated heart failure: results from the Acute Study of Clinical Effectiveness of Nesiritide and Decompensated Heart Failure (ASCEND-HF). Circulation. 2014 Sep 16;130(12):958-65. doi: 10.1161/CIRCULATIONAHA.113.003046. Epub 2014 Jul 29.
PMID: 25074507DERIVEDKaul P, Reed SD, Hernandez AF, Howlett JG, Ezekowitz JA, Li Y, Zheng Y, Rouleau JL, Starling RC, O'Connor CM, Califf RM, Armstrong PW. Differences in treatment, outcomes, and quality of life among patients with heart failure in Canada and the United States. JACC Heart Fail. 2013 Dec;1(6):523-30. doi: 10.1016/j.jchf.2013.07.004. Epub 2013 Oct 23.
PMID: 24622005DERIVEDToma M, Ezekowitz JA, Bakal JA, O'Connor CM, Hernandez AF, Sardar MR, Zolty R, Massie BM, Swedberg K, Armstrong PW, Starling RC. The relationship between left ventricular ejection fraction and mortality in patients with acute heart failure: insights from the ASCEND-HF Trial. Eur J Heart Fail. 2014 Mar;16(3):334-41. doi: 10.1002/ejhf.19. Epub 2013 Dec 14.
PMID: 24464687DERIVEDReed SD, Kaul P, Li Y, Eapen ZJ, Davidson-Ray L, Schulman KA, Massie BM, Armstrong PW, Starling RC, O'Connor CM, Hernandez AF, Califf RM. Medical resource use, costs, and quality of life in patients with acute decompensated heart failure: findings from ASCEND-HF. J Card Fail. 2013 Sep;19(9):611-20. doi: 10.1016/j.cardfail.2013.07.003.
PMID: 24054337DERIVEDHowlett JG, Ezekowitz JA, Podder M, Hernandez AF, Diaz R, Dickstein K, Dunlap ME, Corbalan R, Armstrong PW, Starling RC, O'Connor CM, Califf RM, Fonarow GC; ASCEND-HF Investigators. Global variation in quality of care among patients hospitalized with acute heart failure in an international trial: findings from the acute study clinical effectiveness of nesiritide in decompensated heart failure trial (ASCEND-HF). Circ Cardiovasc Qual Outcomes. 2013 Sep 1;6(5):534-42. doi: 10.1161/CIRCOUTCOMES.113.000119. Epub 2013 Jul 30.
PMID: 23899930DERIVEDEapen ZJ, Reed SD, Li Y, Kociol RD, Armstrong PW, Starling RC, McMurray JJ, Massie BM, Swedberg K, Ezekowitz JA, Fonarow GC, Teerlink JR, Metra M, Whellan DJ, O'Connor CM, Califf RM, Hernandez AF. Do countries or hospitals with longer hospital stays for acute heart failure have lower readmission rates?: Findings from ASCEND-HF. Circ Heart Fail. 2013 Jul;6(4):727-32. doi: 10.1161/CIRCHEARTFAILURE.112.000265. Epub 2013 Jun 14.
PMID: 23770519DERIVEDEzekowitz JA, Hu J, Delgado D, Hernandez AF, Kaul P, Leader R, Proulx G, Virani S, White M, Zieroth S, O'Connor C, Westerhout CM, Armstrong PW. Acute heart failure: perspectives from a randomized trial and a simultaneous registry. Circ Heart Fail. 2012 Nov;5(6):735-41. doi: 10.1161/CIRCHEARTFAILURE.112.968974. Epub 2012 Oct 2.
PMID: 23032196DERIVEDEzekowitz JA, Hernandez AF, O'Connor CM, Starling RC, Proulx G, Weiss MH, Bakal JA, Califf RM, McMurray JJ, Armstrong PW. Assessment of dyspnea in acute decompensated heart failure: insights from ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure) on the contributions of peak expiratory flow. J Am Coll Cardiol. 2012 Apr 17;59(16):1441-8. doi: 10.1016/j.jacc.2011.11.061.
PMID: 22497823DERIVEDO'Connor CM, Starling RC, Hernandez AF, Armstrong PW, Dickstein K, Hasselblad V, Heizer GM, Komajda M, Massie BM, McMurray JJ, Nieminen MS, Reist CJ, Rouleau JL, Swedberg K, Adams KF Jr, Anker SD, Atar D, Battler A, Botero R, Bohidar NR, Butler J, Clausell N, Corbalan R, Costanzo MR, Dahlstrom U, Deckelbaum LI, Diaz R, Dunlap ME, Ezekowitz JA, Feldman D, Felker GM, Fonarow GC, Gennevois D, Gottlieb SS, Hill JA, Hollander JE, Howlett JG, Hudson MP, Kociol RD, Krum H, Laucevicius A, Levy WC, Mendez GF, Metra M, Mittal S, Oh BH, Pereira NL, Ponikowski P, Tang WH, Tanomsup S, Teerlink JR, Triposkiadis F, Troughton RW, Voors AA, Whellan DJ, Zannad F, Califf RM. Effect of nesiritide in patients with acute decompensated heart failure. N Engl J Med. 2011 Jul 7;365(1):32-43. doi: 10.1056/NEJMoa1100171.
PMID: 21732835DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Limitations and Caveats
Only summary counts of deaths by group are provided for other pre-specified endpoints "All-cause mortality through Day 30" and "All-cause mortality through Day 180." Formal statistical comparisons were not planned.
Results Point of Contact
- Title
- Vice President, Franchise Development
- Organization
- Johnson & Johnson Pharmaceutical Research & Development, LLC
Study Officials
- STUDY DIRECTOR
Scios, Inc. Clinical Trial
Scios, Inc.
Publication Agreements
- PI is Sponsor Employee
- No
- Restriction Type
- OTHER
- Restrictive Agreement
- Yes
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 18, 2007
First Posted
May 21, 2007
Study Start
May 1, 2007
Primary Completion
March 1, 2011
Study Completion
March 1, 2011
Last Updated
March 8, 2013
Results First Posted
May 10, 2012
Record last verified: 2013-03