The Use of Nesiritide in Thoracic Aneurysm Repair to Prevent Acute Renal Failure
Prophylactic Use of Nesiritide (Brain Natriuretic Peptide, BNP) for the Prevention of Acute Renal Failure in Thoracic Aortic Aneurysm Surgery Patients
2 other identifiers
interventional
124
1 country
1
Brief Summary
The purpose of this trial is to study the use of nesiritide in thoracic aneurysm repair to prevent acute renal failure. The study hypothesis: Nesiritide, given prophylactically prior to surgery may prevent acute renal failure requiring dialysis and/or decrease mortality.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_3
Started Mar 2005
Typical duration for phase_3
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2005
CompletedFirst Submitted
Initial submission to the registry
May 4, 2005
CompletedFirst Posted
Study publicly available on registry
May 5, 2005
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2007
CompletedJune 24, 2005
May 1, 2005
May 4, 2005
June 23, 2005
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Need for dialysis and/or mortality
Secondary Outcomes (2)
Rise in serum creatinine
blood urea nitrogen
Interventions
Eligibility Criteria
You may qualify if:
- Age 18 years or older
- Undergoing thoracic aortic aneurysm surgery
- Impaired renal function
You may not qualify if:
- Prior history of allergy/adverse reaction to Nesiritide
- History of any organ transplant
- Preoperative intra-aortic balloon pump (IABP)
- Decompensated congestive heart failure (CHF)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Shands Hospital at the University of Florida
Gainesville, Florida, 32610, United States
Related Publications (4)
Hashimoto H, Yamada H, Murata M, Watanabe N. Diuretics for preventing and treating acute kidney injury. Cochrane Database Syst Rev. 2025 Jan 29;1(1):CD014937. doi: 10.1002/14651858.CD014937.pub2.
PMID: 39878152DERIVEDDass B, Shimada M, Kambhampati G, Ejaz NI, Arif AA, Ejaz AA. Fluid balance as an early indicator of acute kidney injury in CV surgery. Clin Nephrol. 2012 Jun;77(6):438-44. doi: 10.5414/cn107278.
PMID: 22595385DERIVEDEjaz AA, Beaver TM, Shimada M, Sood P, Lingegowda V, Schold JD, Kim T, Johnson RJ. Uric acid: a novel risk factor for acute kidney injury in high-risk cardiac surgery patients? Am J Nephrol. 2009;30(5):425-9. doi: 10.1159/000238824. Epub 2009 Sep 11.
PMID: 19752530DERIVEDEjaz AA, Martin TD, Johnson RJ, Winterstein AG, Klodell CT, Hess PJ Jr, Ali AK, Whidden EM, Staples NL, Alexander JA, House-Fancher MA, Beaver TM. Prophylactic nesiritide does not prevent dialysis or all-cause mortality in patients undergoing high-risk cardiac surgery. J Thorac Cardiovasc Surg. 2009 Oct;138(4):959-64. doi: 10.1016/j.jtcvs.2009.05.014. Epub 2009 Jul 3.
PMID: 19660420DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- INDIV
Study Record Dates
First Submitted
May 4, 2005
First Posted
May 5, 2005
Study Start
March 1, 2005
Study Completion
December 1, 2007
Last Updated
June 24, 2005
Record last verified: 2005-05