Measuring Blood Flow in the Brain

NCT00466934 | Completed

• 2 other identifiers: 07013907-N-0139
• Study Type: observational
• Target: 31
• Locations: 1 country
• Sites: 1

Brief Summary

This study will test a method of measuring brain blood flow called near infrared spectroscopy (NIRS). It will determine whether NIRS gives the same results as the more commonly used technique, functional magnetic resonance imaging (fMRI). Healthy normal volunteers between 18 and 60 years of age may be eligible for this study. Participants come to the NIH up to six times for experiments using NIRS and fMRI. They do the following tasks while they are undergoing NIRS or fMRI:

• looking at a computer monitor while a checkerboard pattern changes
• wiggling the toes and moving the fingers
• Reading words on a computer screen and pushing one button if they are plants and another if they are animals. For NIRS, a frame is placed on the head and held it in place with a metal band. The frame holds sensors that contact the scalp. For fMRI, the subject lies on a table that can slide in and out of an MRI scanner, a metal cylinder surrounded by a strong magnetic field. fMRI uses a strong magnetic field and radio waves to obtain images of the brain while the subject performs tasks. During the procedure, The subject wears earplugs to muffle the sound of loud knocking noises that occur during scanning.

Conditions

Traumatic Brain Injury; Healthy

Keywords

Cerebral Blood Flow; Cerebral Cortex; Cognition; Optical Imaging; Healthy Volunteer; HV

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age 18 to 60, inclusive.

You may not qualify if:

• Pregnancy.
• History of hypertension.
• History of any disease of the central nervous system.
• Current use of sedating medication, including antihistamines.
• Subjects with any of the following will be excluded from MRI testing: aneurysm clip; implanted neural stimulator; implanted cardiac pacemaker or auto-defibrillator; cochlear implant; ocular foreign body, such as metal shavings; permanent eyeliner; insulin pump; or irremovable body piercing due to the possible dangerous effects of the MRI magnet upon metal objects in the body.

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead
• United States Department of Defense: collaborator
• National Institutes of Health Clinical Center (CC): collaborator
• Center for Neuroscience and Regenerative Medicine (CNRM): collaborator

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Benaron DA, Hintz SR, Villringer A, Boas D, Kleinschmidt A, Frahm J, Hirth C, Obrig H, van Houten JC, Kermit EL, Cheong WF, Stevenson DK. Noninvasive functional imaging of human brain using light. J Cereb Blood Flow Metab. 2000 Mar;20(3):469-77. doi: 10.1097/00004647-200003000-00005.

  PMID: 10724111 BACKGROUND

• Biswal B, Hudetz AG, Yetkin FZ, Haughton VM, Hyde JS. Hypercapnia reversibly suppresses low-frequency fluctuations in the human motor cortex during rest using echo-planar MRI. J Cereb Blood Flow Metab. 1997 Mar;17(3):301-8. doi: 10.1097/00004647-199703000-00007.

  PMID: 9119903 BACKGROUND

• Biswal B, Yetkin FZ, Haughton VM, Hyde JS. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med. 1995 Oct;34(4):537-41. doi: 10.1002/mrm.1910340409.

  PMID: 8524021 BACKGROUND

MeSH Terms

Conditions

Brain Injuries, Traumatic

Condition Hierarchy (Ancestors)

Brain Injuries; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH

Study Record Dates

• First Submitted: April 26, 2007
• First Posted: April 27, 2007
• Study Start: April 24, 2007
• Study Completion: December 29, 2011
• Last Updated: July 2, 2017

Record last verified: 2011-12-29

Locations

US (1)