Investigation of Correlation Between Interstitial and Arterial Blood Glucose Concentrations in Septic Patients

NCT00463645 | Completed

• 1 other identifier: CM3_adipose
• Study Type: observational
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

This is a mono-centre trial performed at the medical ICU at the Medical University Graz. There will be a study visit (V1) and a follow-up assessment (V2). In the study visit (V1) arterial blood glucose values will be monitored and subcutaneous sampling of interstitial fluid (ISF) with microdialysis for glucose determination and with microperfusion for cytokine-measurement will be performed. The study visit will last for 26 hours starting with the insertion of two catheters in the abdominal subcutaneous tissue (one microdialysis- and one microperfusion catheter). The primary hypothesis of the study is: Interstitial fluid glucose concentration profiles correlates to the arterial blood glucose concentration profile in patients with severe sepsis in the medical ICU.

Conditions

Severe Sepsis

Interventions

microdialysis PROCEDURE

microperfusion PROCEDURE

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients in the medical ICU fulfilling criteria for severe sepsis
• Mechanical ventilation
• Increased blood glucose levels ( \> 120 mg/dL; \> 6.7 mM), or requiring insulin treatment.
• Age of patients in the range from 18 to 90 years.

You may not qualify if:

• Any disease or condition which the Investigator or the treating physician feels would interfere with the trial or the safety of the patient

Sponsors & Collaborators

• Medical University of Graz: lead

Study Sites (1)

Medical University Graz

Graz, Styria, 8036, Austria

Location

MeSH Terms

Conditions

Sepsis

Interventions

Microdialysis

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Dialysis; Chemistry Techniques, Analytical; Investigative Techniques

Study Officials

• Thomas R. Pieber, MD.

  Medical University of Graz

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: DEFINED POPULATION
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: April 19, 2007
• First Posted: April 20, 2007
• Study Start: September 1, 2005
• Study Completion: January 1, 2006
• Last Updated: June 6, 2007

Record last verified: 2007-04

Locations

AU (1)