Optic Nerve Compliance Study

NCT00328835 | Completed

• 1 other identifier: ONCS
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Chronic glaucoma is one of the leading causes of blindness and visual loss in the developed world. It is a condition where long term exposure to high eye pressures (intra-ocular pressure) damages the nerve fibres in the eye. This damage can be seen by examiners as changes in the optic nerve. The exact mechanism of how the high intra-ocular pressure causes nerve damage is unknown. Both physiological and mechanical mechanisms are thought to play a role. Previous authors have reported structural changes in the connective tissue of optic nerves of eyes with glaucoma. Structural changes in the optic nerve head which affect the mechanical compliance of the nerve may be significant in the cause of glaucomatous nerve damage. This study aims to assess the compliance of the optic disc in subjects with and without glaucoma. We would test compliance by imaging the optic discs of participants before and during a brief (less than two minutes) increase in intra-ocular pressure. We would aim to repeat the tests on the same subjects 3 years later to see how compliance changed. We would also seek to correlate other important parameters such as corneal thickness and visual field changes with our findings

Conditions

Glaucoma

Keywords

Optic Nerve; Glaucoma

Outcome Measures

Primary Outcomes (2)

• Optic Disc Change

• Visual Field Progression

Secondary Outcomes (1)

• Visual Acuity Change

Interventions

Brief Elevation of IOP PROCEDURE

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age over 18, Diagnosis of glaucoma (visual field proven), Stable, well controlled glaucoma

You may not qualify if:

• Previous eye surgery, Best corrected visual acuity \<6/9, Chronic eye disease (including glaucoma, Secondary glaucoma (eg uveitis, neovascular glaucoma, etc), Advanced or fixation-threatening visual field changes, Ocular perfusion abnormalities (e.g. previous retinal artery or vein occlusion; or abnormal vasculature including those whose retinal circulation might be compromised by pressure on the eye).

Sponsors & Collaborators

• Capital Vision Research Trust: lead

Study Sites (1)

Capital Vision Research Trust

Wellington, 6001, New Zealand

Location

Related Publications (2)

• Poostchi A, Wong T, Chan KC, Kedzlie L, Sachdev N, Nicholas S, Garway-Heath DF, Wells AP. Optic disc diameter increases during acute elevations of intraocular pressure. Invest Ophthalmol Vis Sci. 2010 May;51(5):2313-6. doi: 10.1167/iovs.09-3756. Epub 2009 Nov 11.

  PMID: 19907027 DERIVED

• Wells AP, Garway-Heath DF, Poostchi A, Wong T, Chan KC, Sachdev N. Corneal hysteresis but not corneal thickness correlates with optic nerve surface compliance in glaucoma patients. Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3262-8. doi: 10.1167/iovs.07-1556. Epub 2008 Mar 3.

  PMID: 18316697 DERIVED

MeSH Terms

Conditions

Glaucoma

Condition Hierarchy (Ancestors)

Ocular Hypertension; Eye Diseases

Study Officials

• Anthony P Wells, FRANZCO

  CVRT, Wellington School Of Medicine - University of Otago

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 18, 2006
• First Posted: May 22, 2006
• Study Start: March 1, 2006
• Study Completion: April 1, 2006
• Last Updated: October 17, 2006

Record last verified: 2006-05

Locations

NZ (1)