Effect Of Nicotine on Neurocognitive Performance of Cigarette Smokers
1 other identifier
interventional
40
1 country
1
Brief Summary
This research project addresses the hypothesis that a neurocognitive profile characterized by impairment of response inhibition and sustained attention may be a risk factor for smoking initiation and nicotine dependence among young women. Nicotine has short- term, facilitating effects on attention and response inhibition. Therefore, individuals who are impaired on cognitive functions such as these and initiate cigarette smoking may be more likely to maintain the habit and develop nicotine dependence. The research protocol specifically tests whether administration of nicotine to non-abstinent, regular cigarette smokers improves cognitive function in those domains where the participants had previously been shown to manifest performance deficits
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Feb 2007
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 30, 2007
CompletedFirst Posted
Study publicly available on registry
January 31, 2007
CompletedStudy Start
First participant enrolled
February 1, 2007
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2007
CompletedJanuary 31, 2007
January 1, 2007
January 30, 2007
January 30, 2007
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Neurocognitive functions
Interventions
Eligibility Criteria
You may qualify if:
- Reported smoking cigarettes on a daily basis at the time of the original study and continue to smoke currently
- Manifested poor performance on the MFFT (The neurocognitive test that yielded differences between smokers and non-smokers)
- Competent and willing to give written informed consent
You may not qualify if:
- Pregnancy, breast-feeding, non-use of contraception such that the possibility of pregnancy cannot be excluded
- Intake of any medication that may potentially interact with nicotine.
- Any current or past medical condition that represents a contra-indication to nicotine administration.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hadassah Medical Organization
Jerusalem, Israel
Related Publications (1)
Yakir A, Rigbi A, Kanyas K, Pollak Y, Kahana G, Karni O, Eitan R, Kertzman S, Lerer B. Why do young women smoke? III. Attention and impulsivity as neurocognitive predisposing factors. Eur Neuropsychopharmacol. 2007 Apr;17(5):339-51. doi: 10.1016/j.euroneuro.2006.09.004. Epub 2006 Nov 30.
PMID: 17141485RESULT
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Avi Yakir, MD
Hadassah Medical Organization
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- DOUBLE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
January 30, 2007
First Posted
January 31, 2007
Study Start
February 1, 2007
Study Completion
April 1, 2007
Last Updated
January 31, 2007
Record last verified: 2007-01