NCT00422474

Brief Summary

After acute stroke, baroreflex sensitivity (BRS) is impaired. This impaired acute stage BRS has been reported to be predictive of worsen outcome years after stroke in general. However, it is not very clear if the impaired acute stroke BRS would actually persist months after the acute stage. It is also not clear that such change, if any, would correlate with the functional outcome or prognosis after stroke. The trial is to investigate the longitudinal time course of BRS after ischemic stroke up to the 6th month post stroke and to see if there is any correlation of the changes in BRS with the functional outcome parameters using NIHSS and mRS scores throughout this period.

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2007

Completed
13 days until next milestone

First Submitted

Initial submission to the registry

January 14, 2007

Completed
3 days until next milestone

First Posted

Study publicly available on registry

January 17, 2007

Completed
Last Updated

July 10, 2008

Status Verified

July 1, 2008

First QC Date

January 14, 2007

Last Update Submit

July 8, 2008

Conditions

Cerebrovascular AccidentBaroreflexesAutonomic Nervous System Diseases

Keywords

Ischemic strokeBaroreflex sensitivityPrognosisCardiovascular autonomic regulation

Eligibility Criteria

Age50 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Baroreflex sensitivity can be done within 72 hours of onset of acute ischemic stroke
  • years old
  • Must have either brain CT or brain MRI done

You may not qualify if:

  • NIHSS score \> 10
  • Patient could not cooperate
  • Unstable vital sign
  • Atrial fibrillation
  • Transient ischemic attack patient
  • Diabetic patient
  • Impaired renal function (Cr \> 2.26 mg/dl)
  • Unstable angina, acute myocardiac infarction, cardiomyopathy patients
  • Patient who has known autonomic dysfunction

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Far Eastern Memorial Hospital

Banqiao District, Taipei, 220, Taiwan

RECRUITING

MeSH Terms

Conditions

StrokeAutonomic Nervous System DiseasesIschemic Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular DisordersBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Study Officials

  • Siupak Lee, M.D.

    Far Eastern Memorial Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Siupak Lee, M.D.

CONTACT

siupakmd@ms1.hinet.net

Study Design

Study Type
observational
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

January 14, 2007

First Posted

January 17, 2007

Study Start

January 1, 2007

Last Updated

July 10, 2008

Record last verified: 2008-07

Locations

TW(1)