Multi-Center Human Alert Trial to Prevent DVT and PE
Physician Alerts to Prevent DVT and Pulmonary Embolism in Hospitalized Patients
1 other identifier
observational
2,496
1 country
26
Brief Summary
To evaluate physician response to human alerts that inform the clinician that his/her patient may be eligible for thromboprophylaxis. Medical records are reviewed to evaluate prescribing decision and to evaluate rates of venous thromboembolism.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2006
Typical duration for all trials
26 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2006
CompletedFirst Submitted
Initial submission to the registry
December 7, 2006
CompletedFirst Posted
Study publicly available on registry
December 8, 2006
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2008
CompletedFebruary 2, 2009
January 1, 2009
2.4 years
December 7, 2006
January 29, 2009
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Clinically diagnosed DVT and/or PE
90 days
Secondary Outcomes (2)
Mortality
30 and 90 days
Hemorrhagic events
30 and 90 days
Study Arms (2)
Alert
Physicians alerted about their high risk patients who are not receiving any VTE prophylaxis.
No Alert
Physicians not alerted about their high risk patients who are not receiving any VTE prophylaxis.
Interventions
An alert from study staff informing a physician that his/her patient is at high risk for DVT and/or PE, but is not receiving any prophylaxis.
Eligibility Criteria
Hospitalized patients that have a cumulative VTE risk score of 4 or more with no orders for prophylactic measures.
You may qualify if:
- Patients \> 18 years of age
- Cumulative VTE risk score \> 4
- Absence of pharmacologic or mechanical prophylaxis orders
- Patients from medical or surgical Services
You may not qualify if:
- VTE risk score \<4
- Current active pharmacologic or mechanical prophylaxis order
- Patients from the Department of Neurology, Newborn Service, Rehab Units, and Neonatal Intensive Care Unit (NICU).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Brigham and Women's Hospitallead
- Sanoficollaborator
Study Sites (26)
AZ Pulmonary Specialists, Ltd
Scottsdale, Arizona, 85258, United States
Long Beach VA Hospital
Long Beach, California, 90822, United States
University of California - Irvine
Orange, California, 92868, United States
University of California - Davis
Sacramento, California, 95817, United States
University of Colorado Health Sciences Center
Denver, Colorado, 80262, United States
Norwalk Hospital
Norwalk, Connecticut, 06850, United States
William W. Backus Hospital
Norwich, Connecticut, 06360, United States
Washington Hospital Center
Washington D.C., District of Columbia, 20010, United States
Florida Hospital
Orlando, Florida, 32803, United States
Emory-Crawford Long Hospital
Atlanta, Georgia, 30308, United States
Franklin Square Hospital
Baltimore, Maryland, 21237, United States
Washington County Hospital
Hagerstown, Maryland, 21740, United States
Lahey Clinic
Burlington, Massachusetts, 01805, United States
North Shore Medical Center
Salem, Massachusetts, 01970, United States
Henry Ford Hospital K15
Detroit, Michigan, 48202, United States
St. Joseph Mercy Hospital
Ypsilanti, Michigan, 48197, United States
University of Missouri
Columbia, Missouri, 65212, United States
North Shore University Hospital
Great Neck, New York, 11030, United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States
Thomas Jefferson Hospital
Philadelphia, Pennsylvania, 19107, United States
Washington Hospital
Washington, Pennsylvania, 15301, United States
Spartanburg Regional Medical Center
Spartanburg, South Carolina, 29303, United States
Presbyterian Hospital of Dallas
Dallas, Texas, 75231, United States
LDS Hospital
Salt Lake City, Utah, 84103, United States
University of Utah Medical Center
Salt Lake City, Utah, 84132, United States
United Hospital System
Kenosha, Wisconsin, 53143, United States
Related Publications (5)
Goldhaber SZ, Turpie AG. Prevention of venous thromboembolism among hospitalized medical patients. Circulation. 2005 Jan 4;111(1):e1-3. doi: 10.1161/01.CIR.0000150393.51958.54. No abstract available.
PMID: 15630031BACKGROUNDGoldhaber SZ, Dunn K, MacDougall RC. New onset of venous thromboembolism among hospitalized patients at Brigham and Women's Hospital is caused more often by prophylaxis failure than by withholding treatment. Chest. 2000 Dec;118(6):1680-4. doi: 10.1378/chest.118.6.1680.
PMID: 11115458BACKGROUNDGoldhaber SZ, Tapson VF; DVT FREE Steering Committee. A prospective registry of 5,451 patients with ultrasound-confirmed deep vein thrombosis. Am J Cardiol. 2004 Jan 15;93(2):259-62. doi: 10.1016/j.amjcard.2003.09.057.
PMID: 14715365BACKGROUNDKucher N, Koo S, Quiroz R, Cooper JM, Paterno MD, Soukonnikov B, Goldhaber SZ. Electronic alerts to prevent venous thromboembolism among hospitalized patients. N Engl J Med. 2005 Mar 10;352(10):969-77. doi: 10.1056/NEJMoa041533.
PMID: 15758007BACKGROUNDPiazza G, Rosenbaum EJ, Pendergast W, Jacobson JO, Pendleton RC, McLaren GD, Elliott CG, Stevens SM, Patton WF, Dabbagh O, Paterno MD, Catapane E, Li Z, Goldhaber SZ. Physician alerts to prevent symptomatic venous thromboembolism in hospitalized patients. Circulation. 2009 Apr 28;119(16):2196-201. doi: 10.1161/CIRCULATIONAHA.108.841197. Epub 2009 Apr 13.
PMID: 19364975DERIVED
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Samuel Z. Goldhaber, MD
Brigham and Women's Hospital
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
December 7, 2006
First Posted
December 8, 2006
Study Start
March 1, 2006
Primary Completion
August 1, 2008
Study Completion
August 1, 2008
Last Updated
February 2, 2009
Record last verified: 2009-01